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- W2070519333 abstract "Evidence from many experiments and observations suggests that the likelihood of ventricular fibrillation is increased in some proportion to the magnitude of local differences in the electrophysiologic state of the ventricular myocardium. Many local anesthetic antiarrhythmic drugs have differing affinities for resting, open and inactivated fast channels. In ischemic or otherwise damaged hearts, local differences in resting potential, action potential upstroke and action potential duration will result in differing degrees of block of fast channels by local anesthetic antiarrhythmic drugs. Such drugs can be expected to add to the preexisting local inhomogeneities of electrophysiologic state and thereby increase the likelihood of fibrillation." @default.
- W2070519333 created "2016-06-24" @default.
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- W2070519333 date "1985-06-01" @default.
- W2070519333 modified "2023-09-30" @default.
- W2070519333 title "Modification of the electrophysiologic matrix by antiarrhythmic drugs" @default.
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- W2070519333 doi "https://doi.org/10.1016/s0735-1097(85)80523-4" @default.
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