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- W2070520816 abstract "Several phosphonylmethoxyalkylpurine and -pyrimidine derivatives related to (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA] and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) were evaluated as inhibitors of African swine fever virus (ASFV) replication in Vero cells. (S)-HPMPA has previously been shown to inhibit ASFV replication at a minimum inhibitory concentration (MIC) of 0.01 μg/ml with a selectivity index of 15000. Of the new compounds tested, the following emerged as the most potent and selective inhibitors of ASFV replication: the cyclic phosphonate of (S)-HPMPA [(S)-cHPMPA] with an MIC of 0.2 μg/ml and a selectivity index of 2500, the 2,6-diaminopurine analogue of (S)-HPMPA [(S)-HPMPDAP] with an MIC of 0.5 μg/ml and a selectivity index of 1400, and the cytosine [(S)-HPMPC] and guanine [(S)-HPMPG] analogues with an MIC of 1 μg/ml and a selectivity index of 600–700." @default.
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- W2070520816 date "1997-04-01" @default.
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- W2070520816 title "Induction of genetic damage and apoptosis by ganciclovir in Chinese hamster ovary cells transfected with the thymidine kinase (tk) gene of HSV-1" @default.
- W2070520816 doi "https://doi.org/10.1016/s0166-3542(97)83273-1" @default.
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