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• W2070527655 abstract "The crustacean hyperglycemic hormone (CHH) of the X-organ sinus gland complex is a multifunctional neurohormone primarily involved in the regulation of blood sugar levels. HPLC analysis of lobster sinus glands revealed two CHH-immunoreactive groups, each consisting of two isoforms with identical amino acid sequences and molecular weights. In order to obtain more information concerning the number and sequences of preproCHHs, and to study their expression, we isolated two full-length cDNAs encoding two different CHH preprohormones. Both preprohormone structures consist of a signal peptide, a CHH-precursor-related peptide and a highly-conserved CHH peptide. Expression studies revealed that the X-organ is not the only source of CHH mRNA because the ventral nerve system also expresses this mRNA. Based on these findings and earlier studies on the effect of eyestalk ablation, implantation of thoracic/abdominal ganglia as well as the multifunctionality of CHH, we postulate that CHH, present in the ventral nerve system is a good candidate for a supplementary role in the control of reproduction and molting." @default.
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• W2070527655 date "1995-01-01" @default.
• W2070527655 modified "2023-10-16" @default.
• W2070527655 title "Cloning and expression of two mRNAs encoding structurally different crustacean hyperglycemic hormone precursors in the lobster Homarus americanus" @default.
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• W2070527655 doi "https://doi.org/10.1016/0167-4781(94)00173-z" @default.
• W2070527655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7999796" @default.
• W2070527655 hasPublicationYear "1995" @default.
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