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- W2070540983 abstract "The p53 protein is the product of a tumor suppressor gene which is subject to an extremely high frequency of structural alterations in human cancer (for review, see Hollstein et al. 1991; Levine et al. 1991; Oren 1992; Donehower and Bradley 1993; Harris and Hollstein 1993; Berns 1994). The main selective advantage of such alterations is probably the elimination of the tumor suppressor functions of the wild-type (wt) p53 protein. However, at least some of the p53 point mutations commonly encountered in tumor cells may also entail an oncogenic gain of function (Wolf et al. 1984; Chen et al. 1990; Michalovitz et al. 1991; Dittmer et al. 1993)." @default.
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- W2070540983 date "1994-01-01" @default.
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- W2070540983 title "Targets for Transcriptional Activation by Wild-type p53: Endogenous Retroviral LTR, Immunoglobulin-like Promoter, and an Internal Promoter of the mdm2 Gene" @default.
- W2070540983 doi "https://doi.org/10.1101/sqb.1994.059.01.027" @default.
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