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- W2070546687 abstract "In excitable cells, the main mediators of sodium conductance across membranes are voltage-gated sodium channels (NaVs). Eukaryotic NaVs are essential elements in neuronal signaling and muscular contraction and in humans have been causally related to a variety of neurological and cardiovascular channelopathies. They are complex heavily glycosylated intrinsic membrane proteins present in only trace quantities that have proven to be challenging objects of study. However, in recent years, a number of simpler prokaryotic sodium channels have been identified, with NaChBac from Bacillus halodurans being the most well-characterized to date. The availability of a bacterial NaV that is amenable to heterologous expression and functional characterization in both bacterial and mammalian systems has provided new opportunities for structure–function studies. This review describes features of NaChBac as an exemplar of this class of bacterial channels, compares prokaryotic and eukaryotic NaVs with respect to their structural organization, pharmacological profiling, and functional kinetics, and discusses how voltage-gated ion channels may have evolved to deal with the complex functional demands of higher organisms." @default.
- W2070546687 created "2016-06-24" @default.
- W2070546687 creator A5006073737 @default.
- W2070546687 creator A5014092272 @default.
- W2070546687 date "2011-07-25" @default.
- W2070546687 modified "2023-10-16" @default.
- W2070546687 title "NaChBac: The Long Lost Sodium Channel Ancestor" @default.
- W2070546687 cites W1533488243 @default.
- W2070546687 cites W1836738800 @default.
- W2070546687 cites W1965191256 @default.
- W2070546687 cites W1968903551 @default.
- W2070546687 cites W1969129798 @default.
- W2070546687 cites W1969577194 @default.
- W2070546687 cites W1970264142 @default.
- W2070546687 cites W1971293653 @default.
- W2070546687 cites W1974274221 @default.
- W2070546687 cites W1976255701 @default.
- W2070546687 cites W1978097389 @default.
- W2070546687 cites W1983187084 @default.
- W2070546687 cites W1983519301 @default.
- W2070546687 cites W1987382493 @default.
- W2070546687 cites W1995422440 @default.
- W2070546687 cites W1996437700 @default.
- W2070546687 cites W1996443524 @default.
- W2070546687 cites W1996629542 @default.
- W2070546687 cites W2000054304 @default.
- W2070546687 cites W2001943456 @default.
- W2070546687 cites W2005496553 @default.
- W2070546687 cites W2012739573 @default.
- W2070546687 cites W2013982228 @default.
- W2070546687 cites W2017522634 @default.
- W2070546687 cites W2021009741 @default.
- W2070546687 cites W2022614248 @default.
- W2070546687 cites W2025173962 @default.
- W2070546687 cites W2025472929 @default.
- W2070546687 cites W2026931978 @default.
- W2070546687 cites W2028512905 @default.
- W2070546687 cites W2028922575 @default.
- W2070546687 cites W2031711352 @default.
- W2070546687 cites W2032734987 @default.
- W2070546687 cites W2035378987 @default.
- W2070546687 cites W2040921407 @default.
- W2070546687 cites W2042183734 @default.
- W2070546687 cites W2044076590 @default.
- W2070546687 cites W2048268501 @default.
- W2070546687 cites W2049520220 @default.
- W2070546687 cites W2049710812 @default.
- W2070546687 cites W2053120786 @default.
- W2070546687 cites W2055051018 @default.
- W2070546687 cites W2057474656 @default.
- W2070546687 cites W2061695857 @default.
- W2070546687 cites W2084670381 @default.
- W2070546687 cites W2085543004 @default.
- W2070546687 cites W2087133824 @default.
- W2070546687 cites W2092289479 @default.
- W2070546687 cites W2094592032 @default.
- W2070546687 cites W2097942186 @default.
- W2070546687 cites W2098499866 @default.
- W2070546687 cites W2100557540 @default.
- W2070546687 cites W2100995549 @default.
- W2070546687 cites W2101072772 @default.
- W2070546687 cites W2101204196 @default.
- W2070546687 cites W2102685605 @default.
- W2070546687 cites W2104415321 @default.
- W2070546687 cites W2106207499 @default.
- W2070546687 cites W2106882534 @default.
- W2070546687 cites W2107724701 @default.
- W2070546687 cites W2111344251 @default.
- W2070546687 cites W2120080015 @default.
- W2070546687 cites W2123492974 @default.
- W2070546687 cites W2124653618 @default.
- W2070546687 cites W2128336028 @default.
- W2070546687 cites W2129206515 @default.
- W2070546687 cites W2140774340 @default.
- W2070546687 cites W2143070723 @default.
- W2070546687 cites W2148658393 @default.
- W2070546687 cites W2151757076 @default.
- W2070546687 cites W2152292586 @default.
- W2070546687 cites W2152770371 @default.
- W2070546687 cites W2153817872 @default.
- W2070546687 cites W2157559661 @default.
- W2070546687 cites W2160384970 @default.
- W2070546687 cites W2161749769 @default.
- W2070546687 cites W2164829352 @default.
- W2070546687 cites W2198982186 @default.
- W2070546687 cites W2331664942 @default.
- W2070546687 doi "https://doi.org/10.1021/bi200942y" @default.
- W2070546687 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3153336" @default.
- W2070546687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21770445" @default.
- W2070546687 hasPublicationYear "2011" @default.
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