Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070550048> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2070550048 endingPage "431" @default.
- W2070550048 startingPage "417" @default.
- W2070550048 abstract "The role of cyclic nucleotides as intracellular second messengers mediating the excitatory chronotropic and inotropic actions of octopamine (OCT) and dopamine (DA) on the neurogenic Limulus heart was investigated. Tissue levels of cAMP, but not cGMP, were significantly increased in isolated cardiac ganglia and cardiac muscle following 10 min exposure to 10(-5) M OCT or 10(-5) M DA. In both tissues, OCT elicited larger increases in cAMP than did DA. Amine-induced cAMP accumulation in the cardiac ganglion and in the cardiac muscle was prevented by the alpha-adrenergic blocker phentolamine. The adenylate cyclase activator forskolin and the phosphodiesterase inhibitor IBMX produced amine-like chronotropic and inotropic effects when applied to the isolated heart preparation. However, the kinetics of the responses differed for the two agents. Additional pharmacological agents (RO-20-1724, papaverine, SQ 20,009, and 8-parachloro-phenylthio cAMP) also had amine-like effects but to a lesser extent. The chronotropic, but not inotropic, effects of OCT and DA were potentiated in the presence of IBMX. These data suggest that a cAMP-dependent mechanism underlies the excitatory effects of the neuromodulators OCT and DA on the Limulus heart." @default.
- W2070550048 created "2016-06-24" @default.
- W2070550048 creator A5001641334 @default.
- W2070550048 creator A5081794734 @default.
- W2070550048 date "1987-09-01" @default.
- W2070550048 modified "2023-09-24" @default.
- W2070550048 title "Mechanism for amine modulation of the neurogenicLimulus heart: Evidence for involvement of cAMP" @default.
- W2070550048 cites W1775749144 @default.
- W2070550048 cites W1904516040 @default.
- W2070550048 cites W1947821840 @default.
- W2070550048 cites W1956335077 @default.
- W2070550048 cites W1967336487 @default.
- W2070550048 cites W1986864872 @default.
- W2070550048 cites W1990919605 @default.
- W2070550048 cites W2004783648 @default.
- W2070550048 cites W2008622254 @default.
- W2070550048 cites W2008845239 @default.
- W2070550048 cites W2009291798 @default.
- W2070550048 cites W2023916700 @default.
- W2070550048 cites W2046349235 @default.
- W2070550048 cites W2059138820 @default.
- W2070550048 cites W2069406138 @default.
- W2070550048 cites W2117001488 @default.
- W2070550048 cites W2137918188 @default.
- W2070550048 cites W2313154362 @default.
- W2070550048 cites W2341194504 @default.
- W2070550048 cites W2438826700 @default.
- W2070550048 cites W2495025554 @default.
- W2070550048 cites W2513760950 @default.
- W2070550048 doi "https://doi.org/10.1002/neu.480180504" @default.
- W2070550048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2443616" @default.
- W2070550048 hasPublicationYear "1987" @default.
- W2070550048 type Work @default.
- W2070550048 sameAs 2070550048 @default.
- W2070550048 citedByCount "10" @default.
- W2070550048 countsByYear W20705500482018 @default.
- W2070550048 crossrefType "journal-article" @default.
- W2070550048 hasAuthorship W2070550048A5001641334 @default.
- W2070550048 hasAuthorship W2070550048A5081794734 @default.
- W2070550048 hasConcept C126322002 @default.
- W2070550048 hasConcept C134018914 @default.
- W2070550048 hasConcept C155710745 @default.
- W2070550048 hasConcept C158328960 @default.
- W2070550048 hasConcept C163235415 @default.
- W2070550048 hasConcept C181199279 @default.
- W2070550048 hasConcept C24998067 @default.
- W2070550048 hasConcept C2777953023 @default.
- W2070550048 hasConcept C2779276759 @default.
- W2070550048 hasConcept C2780253649 @default.
- W2070550048 hasConcept C2781298581 @default.
- W2070550048 hasConcept C55493867 @default.
- W2070550048 hasConcept C62826618 @default.
- W2070550048 hasConcept C71924100 @default.
- W2070550048 hasConcept C79879829 @default.
- W2070550048 hasConcept C84393581 @default.
- W2070550048 hasConcept C86803240 @default.
- W2070550048 hasConceptScore W2070550048C126322002 @default.
- W2070550048 hasConceptScore W2070550048C134018914 @default.
- W2070550048 hasConceptScore W2070550048C155710745 @default.
- W2070550048 hasConceptScore W2070550048C158328960 @default.
- W2070550048 hasConceptScore W2070550048C163235415 @default.
- W2070550048 hasConceptScore W2070550048C181199279 @default.
- W2070550048 hasConceptScore W2070550048C24998067 @default.
- W2070550048 hasConceptScore W2070550048C2777953023 @default.
- W2070550048 hasConceptScore W2070550048C2779276759 @default.
- W2070550048 hasConceptScore W2070550048C2780253649 @default.
- W2070550048 hasConceptScore W2070550048C2781298581 @default.
- W2070550048 hasConceptScore W2070550048C55493867 @default.
- W2070550048 hasConceptScore W2070550048C62826618 @default.
- W2070550048 hasConceptScore W2070550048C71924100 @default.
- W2070550048 hasConceptScore W2070550048C79879829 @default.
- W2070550048 hasConceptScore W2070550048C84393581 @default.
- W2070550048 hasConceptScore W2070550048C86803240 @default.
- W2070550048 hasIssue "5" @default.
- W2070550048 hasLocation W20705500481 @default.
- W2070550048 hasLocation W20705500482 @default.
- W2070550048 hasOpenAccess W2070550048 @default.
- W2070550048 hasPrimaryLocation W20705500481 @default.
- W2070550048 hasRelatedWork W1715376164 @default.
- W2070550048 hasRelatedWork W1953917057 @default.
- W2070550048 hasRelatedWork W1982310992 @default.
- W2070550048 hasRelatedWork W2047047133 @default.
- W2070550048 hasRelatedWork W2053936620 @default.
- W2070550048 hasRelatedWork W2070550048 @default.
- W2070550048 hasRelatedWork W2075291319 @default.
- W2070550048 hasRelatedWork W2123570665 @default.
- W2070550048 hasRelatedWork W2167842763 @default.
- W2070550048 hasRelatedWork W2421755449 @default.
- W2070550048 hasVolume "18" @default.
- W2070550048 isParatext "false" @default.
- W2070550048 isRetracted "false" @default.
- W2070550048 magId "2070550048" @default.
- W2070550048 workType "article" @default.