FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070553525> ?p ?o ?g. }

• W2070553525 endingPage "6355" @default.
• W2070553525 startingPage "6343" @default.
• W2070553525 abstract "Paullones constitute a class of potent cyclin-dependent kinase inhibitors. To overcome the insufficient solubility and bioavailability, which hamper their potential medical application, we aim at the development of metal-based derivatives. Two types of paullone ligands, L (1) - L (3) and L (4) , with different locations of metal-binding sites, were prepared. They were found to form organometallic complexes of the general formula [M (II)Cl(eta (6)- p-cymene)L]Cl ( 1- 4, L = L (1) - L (4) ; a, M = Ru; b, M = Os). The complexes were characterized by X-ray crystallography, one- and two-dimensional NMR spectroscopy and other physical methods. Complexes 1- 3, with a coordinated amidine unit, were found to undergo E/ Z isomerization in solution. The reaction was studied by NMR spectroscopy, and activation parameters Delta H (double dagger) and Delta S (double dagger) were determined. Antiproliferative activity in the low micromolar range was observed in vitro in three human cancer cell lines by means of MTT assays. (3)H-Thymidine incorporation assays revealed the compounds to lower the rate of DNA synthesis, and flow cytometric analyses showed cell cycle arrest mainly in G 0/ G 1 phase." @default.
• W2070553525 created "2016-06-24" @default.
• W2070553525 creator A5004914119 @default.
• W2070553525 creator A5012325523 @default.
• W2070553525 creator A5021405645 @default.
• W2070553525 creator A5033593586 @default.
• W2070553525 creator A5034302513 @default.
• W2070553525 creator A5038189093 @default.
• W2070553525 creator A5043913136 @default.
• W2070553525 creator A5068087465 @default.
• W2070553525 creator A5073511300 @default.
• W2070553525 date "2007-11-13" @default.
• W2070553525 modified "2023-09-24" @default.
• W2070553525 title "Metal-Based Paullones as Putative CDK Inhibitors for Antitumor Chemotherapy" @default.
• W2070553525 cites W1967308727 @default.
• W2070553525 cites W1967517956 @default.
• W2070553525 cites W1969930033 @default.
• W2070553525 cites W1976656978 @default.
• W2070553525 cites W1977112537 @default.
• W2070553525 cites W1977873784 @default.
• W2070553525 cites W1980349560 @default.
• W2070553525 cites W1981317908 @default.
• W2070553525 cites W1981603699 @default.
• W2070553525 cites W1999319877 @default.
• W2070553525 cites W1999956087 @default.
• W2070553525 cites W2002015225 @default.
• W2070553525 cites W2007852796 @default.
• W2070553525 cites W2008925254 @default.
• W2070553525 cites W2014525894 @default.
• W2070553525 cites W2017346763 @default.
• W2070553525 cites W2019215249 @default.
• W2070553525 cites W2019661323 @default.
• W2070553525 cites W2020462998 @default.
• W2070553525 cites W2021527389 @default.
• W2070553525 cites W2030841140 @default.
• W2070553525 cites W2032842297 @default.
• W2070553525 cites W2039038930 @default.
• W2070553525 cites W2040593990 @default.
• W2070553525 cites W2044399783 @default.
• W2070553525 cites W2048322679 @default.
• W2070553525 cites W2051876103 @default.
• W2070553525 cites W2053409523 @default.
• W2070553525 cites W2055286653 @default.
• W2070553525 cites W2059583857 @default.
• W2070553525 cites W2065402334 @default.
• W2070553525 cites W2069305922 @default.
• W2070553525 cites W2069305928 @default.
• W2070553525 cites W2073659874 @default.
• W2070553525 cites W2085229345 @default.
• W2070553525 cites W2088912553 @default.
• W2070553525 cites W2103268811 @default.
• W2070553525 cites W2108316612 @default.
• W2070553525 cites W2126695283 @default.
• W2070553525 cites W2129213133 @default.
• W2070553525 cites W2130721257 @default.
• W2070553525 cites W2146600312 @default.
• W2070553525 cites W2950585844 @default.
• W2070553525 cites W2951084657 @default.
• W2070553525 doi "https://doi.org/10.1021/jm701042w" @default.
• W2070553525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17997519" @default.
• W2070553525 hasPublicationYear "2007" @default.
• W2070553525 type Work @default.
• W2070553525 sameAs 2070553525 @default.
• W2070553525 citedByCount "82" @default.
• W2070553525 countsByYear W20705535252012 @default.
• W2070553525 countsByYear W20705535252013 @default.
• W2070553525 countsByYear W20705535252014 @default.
• W2070553525 countsByYear W20705535252015 @default.
• W2070553525 countsByYear W20705535252016 @default.
• W2070553525 countsByYear W20705535252017 @default.
• W2070553525 countsByYear W20705535252018 @default.
• W2070553525 countsByYear W20705535252019 @default.
• W2070553525 countsByYear W20705535252020 @default.
• W2070553525 countsByYear W20705535252021 @default.
• W2070553525 countsByYear W20705535252022 @default.
• W2070553525 countsByYear W20705535252023 @default.
• W2070553525 crossrefType "journal-article" @default.
• W2070553525 hasAuthorship W2070553525A5004914119 @default.
• W2070553525 hasAuthorship W2070553525A5012325523 @default.
• W2070553525 hasAuthorship W2070553525A5021405645 @default.
• W2070553525 hasAuthorship W2070553525A5033593586 @default.
• W2070553525 hasAuthorship W2070553525A5034302513 @default.
• W2070553525 hasAuthorship W2070553525A5038189093 @default.
• W2070553525 hasAuthorship W2070553525A5043913136 @default.
• W2070553525 hasAuthorship W2070553525A5068087465 @default.
• W2070553525 hasAuthorship W2070553525A5073511300 @default.
• W2070553525 hasConcept C126661725 @default.
• W2070553525 hasConcept C155647269 @default.
• W2070553525 hasConcept C161790260 @default.
• W2070553525 hasConcept C178790620 @default.
• W2070553525 hasConcept C185592680 @default.
• W2070553525 hasConcept C2778622868 @default.
• W2070553525 hasConcept C544153396 @default.
• W2070553525 hasConcept C55493867 @default.
• W2070553525 hasConcept C66974803 @default.
• W2070553525 hasConcept C71240020 @default.
• W2070553525 hasConceptScore W2070553525C126661725 @default.
• W2070553525 hasConceptScore W2070553525C155647269 @default.

• next