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- W2070555156 abstract "Methods OPTIMA prelim, the feasibility phase, aims to recruit 300 patients to evaluate performance and health-economics of a number of multi-parameter tests to identify test(s) to be used in the main trial and to establish the acceptability to patients and clinicians of randomisation. Patients are randomised to the standard arm or to the “test-directed treatment” arm according to the result of Oncotype DX test. The decision to roll forward into the main trial will be determined by the willingness of patients to be randomised, concordance and cost of the multi-parameter tests. Cost-effectiveness models will be based on the model developed in preparation for the OPTIMA trial, updated with contemporary evidence from the feasibility study and appropriate external data, e.g. the Ontario OncotypeDX field evaluation (prospective cohort study)." @default.
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- W2070555156 date "2013-01-01" @default.
- W2070555156 modified "2023-09-23" @default.
- W2070555156 title "Using adaptive designs for decision making within the optima trial: optimal personalized treatment of early breast cancer using multi-parameter tests" @default.
- W2070555156 doi "https://doi.org/10.1186/1745-6215-14-s1-o12" @default.
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