FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070559218> ?p ?o ?g. }

• W2070559218 endingPage "47" @default.
• W2070559218 startingPage "39" @default.
• W2070559218 abstract "Blockade of dopamine D1 receptors has been suggested as a novel therapeutic approach to psychotic disorders and to psychomotor stimulant dependencies. Peripheral D1 receptors have also been implicated in the acute lethal effects of cocaine. Attempts to synthesize a D1 antagonist that does not penetrate the central nervous system led to the discovery of a novel series of N-alkylaminobenzazepine D1 antagonists. In the present study, the most potent compound of that series, JHS 271, suppressed locomotor activity, and blocked cocaine-stimulated activity, apomorphine-induced stereotypies, and the lethal effects of cocaine in mice. Structural analogs of JHS 271 were also evaluated in selected assays. Potencies in these tests demonstrated a significant positive correlation with affinities for the D1 receptor. These results implicate D1 receptor blockade as a mechanism of action for JHS 271 and related compounds. Comparative studies of central vs. systemic administration and determination of blood/brain concentrations indicated that JHS 271, like SCH 23390, can readily access central sites upon systemic application. © 1996 Wiley-Liss, Inc." @default.
• W2070559218 created "2016-06-24" @default.
• W2070559218 creator A5040741799 @default.
• W2070559218 creator A5040827062 @default.
• W2070559218 creator A5045732236 @default.
• W2070559218 creator A5061926206 @default.
• W2070559218 creator A5070414240 @default.
• W2070559218 creator A5090899159 @default.
• W2070559218 creator A5054352128 @default.
• W2070559218 date "1996-01-01" @default.
• W2070559218 modified "2023-09-24" @default.
• W2070559218 title "Behavioral effects and dopamine antagonist properties of N-alkylaminobenzazepines" @default.
• W2070559218 cites W1824863696 @default.
• W2070559218 cites W1977606388 @default.
• W2070559218 cites W1983518330 @default.
• W2070559218 cites W1986353650 @default.
• W2070559218 cites W1987174439 @default.
• W2070559218 cites W2013795670 @default.
• W2070559218 cites W2017660743 @default.
• W2070559218 cites W2023292449 @default.
• W2070559218 cites W2053620253 @default.
• W2070559218 cites W2056961834 @default.
• W2070559218 cites W2067893159 @default.
• W2070559218 cites W2078121779 @default.
• W2070559218 cites W2078334691 @default.
• W2070559218 cites W2084676667 @default.
• W2070559218 cites W2086570260 @default.
• W2070559218 cites W2091764564 @default.
• W2070559218 cites W2092730555 @default.
• W2070559218 cites W2314926927 @default.
• W2070559218 cites W2418602662 @default.
• W2070559218 cites W30133754 @default.
• W2070559218 doi "https://doi.org/10.1002/(sici)1098-2299(199601)37:1<39::aid-ddr2>3.0.co;2-n" @default.
• W2070559218 hasPublicationYear "1996" @default.
• W2070559218 type Work @default.
• W2070559218 sameAs 2070559218 @default.
• W2070559218 citedByCount "0" @default.
• W2070559218 crossrefType "journal-article" @default.
• W2070559218 hasAuthorship W2070559218A5040741799 @default.
• W2070559218 hasAuthorship W2070559218A5040827062 @default.
• W2070559218 hasAuthorship W2070559218A5045732236 @default.
• W2070559218 hasAuthorship W2070559218A5054352128 @default.
• W2070559218 hasAuthorship W2070559218A5061926206 @default.
• W2070559218 hasAuthorship W2070559218A5070414240 @default.
• W2070559218 hasAuthorship W2070559218A5090899159 @default.
• W2070559218 hasConcept C120069818 @default.
• W2070559218 hasConcept C120750228 @default.
• W2070559218 hasConcept C126322002 @default.
• W2070559218 hasConcept C134018914 @default.
• W2070559218 hasConcept C137183658 @default.
• W2070559218 hasConcept C170493617 @default.
• W2070559218 hasConcept C185592680 @default.
• W2070559218 hasConcept C2776885963 @default.
• W2070559218 hasConcept C2777193897 @default.
• W2070559218 hasConcept C2777525119 @default.
• W2070559218 hasConcept C2778468042 @default.
• W2070559218 hasConcept C2779459141 @default.
• W2070559218 hasConcept C2779917531 @default.
• W2070559218 hasConcept C2780557958 @default.
• W2070559218 hasConcept C2781353949 @default.
• W2070559218 hasConcept C44208683 @default.
• W2070559218 hasConcept C513476851 @default.
• W2070559218 hasConcept C71924100 @default.
• W2070559218 hasConcept C98274493 @default.
• W2070559218 hasConceptScore W2070559218C120069818 @default.
• W2070559218 hasConceptScore W2070559218C120750228 @default.
• W2070559218 hasConceptScore W2070559218C126322002 @default.
• W2070559218 hasConceptScore W2070559218C134018914 @default.
• W2070559218 hasConceptScore W2070559218C137183658 @default.
• W2070559218 hasConceptScore W2070559218C170493617 @default.
• W2070559218 hasConceptScore W2070559218C185592680 @default.
• W2070559218 hasConceptScore W2070559218C2776885963 @default.
• W2070559218 hasConceptScore W2070559218C2777193897 @default.
• W2070559218 hasConceptScore W2070559218C2777525119 @default.
• W2070559218 hasConceptScore W2070559218C2778468042 @default.
• W2070559218 hasConceptScore W2070559218C2779459141 @default.
• W2070559218 hasConceptScore W2070559218C2779917531 @default.
• W2070559218 hasConceptScore W2070559218C2780557958 @default.
• W2070559218 hasConceptScore W2070559218C2781353949 @default.
• W2070559218 hasConceptScore W2070559218C44208683 @default.
• W2070559218 hasConceptScore W2070559218C513476851 @default.
• W2070559218 hasConceptScore W2070559218C71924100 @default.
• W2070559218 hasConceptScore W2070559218C98274493 @default.
• W2070559218 hasIssue "1" @default.
• W2070559218 hasLocation W20705592181 @default.
• W2070559218 hasOpenAccess W2070559218 @default.
• W2070559218 hasPrimaryLocation W20705592181 @default.
• W2070559218 hasRelatedWork W1973949182 @default.
• W2070559218 hasRelatedWork W1993761316 @default.
• W2070559218 hasRelatedWork W2007401955 @default.
• W2070559218 hasRelatedWork W2009579516 @default.
• W2070559218 hasRelatedWork W2024715714 @default.
• W2070559218 hasRelatedWork W2026809006 @default.
• W2070559218 hasRelatedWork W2036959531 @default.
• W2070559218 hasRelatedWork W2037253830 @default.
• W2070559218 hasRelatedWork W2070559218 @default.
• W2070559218 hasRelatedWork W2086284838 @default.
• W2070559218 hasVolume "37" @default.

• next