FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070565619> ?p ?o ?g. }

• W2070565619 endingPage "1417" @default.
• W2070565619 startingPage "1409" @default.
• W2070565619 abstract "Since the widespread use of exogenous lung surfactant to treat neonatal respiratory distress syndrome, premature infant survival and respiratory morbidity have dramatically improved. Despite the effectiveness of the animal-derived surfactant preparations, there still remain some concerns and difficulties associated with their use. This has prompted investigation into the creation of synthetic surfactant preparations. However, to date, no clinically used synthetic formulation is as effective as the natural material. This is largely because the previous synthetic formulations lacked analogues of the hydrophobic proteins of the lung surfactant system, SP-B and SP-C, which are critical functional constituents. As a result, recent investigation has turned toward the development of a new generation of synthetic, biomimetic surfactants that contain synthetic phospholipids along with a mimic of the hydrophobic protein portion of lung surfactant. In this Account, we detail our efforts in creating accurate mimics of SP-C for use in a synthetic surfactant replacement therapy. Despite SP-C's seemingly simple structure, the predominantly helical protein is extraordinarily challenging to work with given its extreme hydrophobicity and structural instability, which greatly complicates the creation of an effective SP-C analogue. Drawing inspiration from Nature, two promising biomimetic approaches have led to the creation of rationally designed biopolymers that recapitulate many of SP-C's molecular features. The first approach utilizes detailed SP-C structure-activity relationships and amino acid folding propensities to create a peptide-based analogue, SP-C33. In SP-C33, the problematic and metastable polyvaline helix is replaced with a structurally stable polyleucine helix and includes a well-placed positive charge to prevent aggregation. SP-C33 is structurally stable and eliminates the association propensity of the native protein. The second approach follows the same design considerations but makes use of a non-natural, poly-N-substituted glycine or peptoid scaffold to circumvent the difficulties associated with SP-C. By incorporating unique biomimetic side chains in a non-natural backbone, the peptoid mimic captures both SP-C's hydrophobic patterning and its helical secondary structure. Despite the differences in structure, both SP-C33 and the SP-C peptoid mimic capture many requisite features of SP-C. In a surfactant environment, these analogues also replicate many of the key surface activities necessary for a functional biomimetic surfactant therapy while overcoming the difficulties associated with the natural protein. With improved stability, greater production potential, and elimination of possible pathogenic contamination, these biomimetic surfactant formulations offer not only the potential to improve the treatment of respiratory distress syndrome but also the opportunity to treat other respiratory-related disorders." @default.
• W2070565619 created "2016-06-24" @default.
• W2070565619 creator A5013082584 @default.
• W2070565619 creator A5020365644 @default.
• W2070565619 creator A5072218846 @default.
• W2070565619 date "2008-10-04" @default.
• W2070565619 modified "2023-10-16" @default.
• W2070565619 title "Biomimicry of Surfactant Protein C" @default.
• W2070565619 cites W12154069 @default.
• W2070565619 cites W1913936883 @default.
• W2070565619 cites W1964325149 @default.
• W2070565619 cites W1966079789 @default.
• W2070565619 cites W1969644422 @default.
• W2070565619 cites W1973626490 @default.
• W2070565619 cites W1976872518 @default.
• W2070565619 cites W1980577048 @default.
• W2070565619 cites W1983393027 @default.
• W2070565619 cites W1988310575 @default.
• W2070565619 cites W1989728523 @default.
• W2070565619 cites W1991186228 @default.
• W2070565619 cites W1993875393 @default.
• W2070565619 cites W1993906884 @default.
• W2070565619 cites W2003347896 @default.
• W2070565619 cites W2007326604 @default.
• W2070565619 cites W2009713659 @default.
• W2070565619 cites W2012162902 @default.
• W2070565619 cites W2013804424 @default.
• W2070565619 cites W2014516639 @default.
• W2070565619 cites W2018769240 @default.
• W2070565619 cites W2019469428 @default.
• W2070565619 cites W2021013938 @default.
• W2070565619 cites W2021904926 @default.
• W2070565619 cites W2026218538 @default.
• W2070565619 cites W2029303593 @default.
• W2070565619 cites W2032853605 @default.
• W2070565619 cites W2035272842 @default.
• W2070565619 cites W2047235897 @default.
• W2070565619 cites W2057923438 @default.
• W2070565619 cites W2059618188 @default.
• W2070565619 cites W2065424532 @default.
• W2070565619 cites W2068050957 @default.
• W2070565619 cites W2083280971 @default.
• W2070565619 cites W2086836664 @default.
• W2070565619 cites W2090237499 @default.
• W2070565619 cites W2091442298 @default.
• W2070565619 cites W2092388871 @default.
• W2070565619 cites W2097381251 @default.
• W2070565619 cites W2108914108 @default.
• W2070565619 cites W2110023782 @default.
• W2070565619 cites W2113150334 @default.
• W2070565619 cites W2118218863 @default.
• W2070565619 cites W2119048205 @default.
• W2070565619 cites W2126077262 @default.
• W2070565619 cites W2129304318 @default.
• W2070565619 cites W2147898932 @default.
• W2070565619 cites W2147913212 @default.
• W2070565619 cites W2151320720 @default.
• W2070565619 cites W2169973880 @default.
• W2070565619 cites W2223090084 @default.
• W2070565619 cites W4232147078 @default.
• W2070565619 cites W4244012555 @default.
• W2070565619 doi "https://doi.org/10.1021/ar800058t" @default.
• W2070565619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3270935" @default.
• W2070565619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18834153" @default.
• W2070565619 hasPublicationYear "2008" @default.
• W2070565619 type Work @default.
• W2070565619 sameAs 2070565619 @default.
• W2070565619 citedByCount "36" @default.
• W2070565619 countsByYear W20705656192012 @default.
• W2070565619 countsByYear W20705656192013 @default.
• W2070565619 countsByYear W20705656192014 @default.
• W2070565619 countsByYear W20705656192015 @default.
• W2070565619 countsByYear W20705656192016 @default.
• W2070565619 countsByYear W20705656192017 @default.
• W2070565619 countsByYear W20705656192018 @default.
• W2070565619 countsByYear W20705656192019 @default.
• W2070565619 countsByYear W20705656192021 @default.
• W2070565619 countsByYear W20705656192023 @default.
• W2070565619 crossrefType "journal-article" @default.
• W2070565619 hasAuthorship W2070565619A5013082584 @default.
• W2070565619 hasAuthorship W2070565619A5020365644 @default.
• W2070565619 hasAuthorship W2070565619A5072218846 @default.
• W2070565619 hasBestOaLocation W20705656192 @default.
• W2070565619 hasConcept C119599485 @default.
• W2070565619 hasConcept C12554922 @default.
• W2070565619 hasConcept C127413603 @default.
• W2070565619 hasConcept C171250308 @default.
• W2070565619 hasConcept C185592680 @default.
• W2070565619 hasConcept C192562407 @default.
• W2070565619 hasConcept C2776545253 @default.
• W2070565619 hasConcept C55493867 @default.
• W2070565619 hasConcept C58226133 @default.
• W2070565619 hasConcept C70721500 @default.
• W2070565619 hasConcept C86803240 @default.
• W2070565619 hasConceptScore W2070565619C119599485 @default.
• W2070565619 hasConceptScore W2070565619C12554922 @default.
• W2070565619 hasConceptScore W2070565619C127413603 @default.
• W2070565619 hasConceptScore W2070565619C171250308 @default.

• next