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• W2070568133 abstract "The CD8 + T cell clone 5F1 produces interleukin 10 (IL‐10) and interferon γ (IFN‐γ) in response to stimulation with a peptide corresponding to region 142–149 of bovine α s1 ‐casein (p142–149). Ninety analog peptides derived from p142–149 with single amino acid substitutions of putative T cell receptor contact residues were prepared to examine whether production of IL‐10 and IFN‐γ by 5F1 can be altered by stimulation with these peptides. We found that some peptides triggered only IL‐10 production whereas others induced production of IFN‐γ alone or both of these cytokines. Peptides inducing IFN‐γ production triggered both cytotoxicity and a proliferative response, whereas peptides inducing production of IL‐10 but not IFN‐γ triggered neither of these responses. Our results clearly demonstrate that the signaling pathway required for IL‐10 production in CD8 + T cells differs from that required for IFN‐γ production. The distinct cellular signals for IL‐10 production appear to be independent of those for cytotoxicity and the proliferative response of CD8 + T cells." @default.
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• W2070568133 date "1998-02-20" @default.
• W2070568133 modified "2023-10-14" @default.
• W2070568133 title "Selective induction of CD8⁺T cell functions by single substituted analogs of an antigenic peptide: distinct signals for IL-10 production" @default.
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• W2070568133 doi "https://doi.org/10.1016/s0014-5793(98)00082-9" @default.
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