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- W2070571983 abstract "The e antigen HB<sub>e</sub>Ag and its antibody anti-HB have been said to be predictive of chronicity and resolution, respectively, in viral hepatitis. We found, as have others, a specific association with hepatitis B virus-induced disease. In addition, detectability of HB<sub>e</sub>Ag in the acute phase of type B hepatitis was followed by a sixfold higher incidence of chronic hepatitis. Unfortunately, the prediction was erroneous in 65% of positive cases and 6% of negative cases. In chronic hepatitis, HB<sub>e</sub>Ag did not necessarily disappear in advance of resolution, and its disappearance did not necessarily indicate resolution. Two patients with acute hepatitis progressing to chronicity were anti-HB<sub>e</sub>-positive in both phases, as were seven (5%) with chronic hepatitis. For individual patients, therefore, HB<sub>e</sub>Ag and anti-HB<sub>e</sub>are not prognostically useful indexes. (<i>JAMA</i>238:2501-2503,1977)" @default.
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- W2070571983 date "1977-12-05" @default.
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- W2070571983 title "Prognostic Implications of the e Antigen of Hepatitis B Virus" @default.
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- W2070571983 doi "https://doi.org/10.1001/jama.1977.03280240047018" @default.
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