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- W2070572389 abstract "The general clinical use of an RBE of 3 for neutrons is shown to be not only incorrect but also dangerous. RBE is dependent on the dose/fraction of either photons or neutrons and differs for different tissues. It is particularly high for the CNS at the doses/fraction used in therapy. Data from neutron therapy trials are used to illustrate the dangers of using an RBE of 3 regardless of dose/fraction or tissue and to compare the estimated tolerance level for spinal cord with clinical findings. It is suggested that for clinical use RBE should normally be plotted against photon dose/fraction. Neutron tolerance can then be determined directly from the total dose in an acceptable photon schedule by using the RBE at the photon dose/fraction used in the photon schedule. No NSD relationship need then be assumed, thus reducing the uncertainties. The RBE for the CNS is contrasted with that for skin damage; at a photon dose/fraction of 180 rad, the RBE for the CNS is about 5.3, compared with about 4.3 for skin damage. The estimate of tolerance to the cervical cord is 850 rad neutrons. This is in good agreement with clinical findings." @default.
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- W2070572389 date "1981-05-01" @default.
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- W2070572389 title "RBE values for neutron therapy: A simple method for converting acceptable photon dose to limiting neutron dose" @default.
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- W2070572389 doi "https://doi.org/10.1016/0360-3016(81)90373-4" @default.
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