FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070575343> ?p ?o ?g. }

• W2070575343 endingPage "551" @default.
• W2070575343 startingPage "543" @default.
• W2070575343 abstract "Kinase inhibitors are at the forefront of modern drug research, where mostly three technologies are used for hit-and-lead finding: high throughput screening of random libraries, threedimensional structure-based drug design based on X-ray data, and focused libraries around limited number of new cores. Our novel Nested Chemical Library™ (NCL) (Vichem Chemie Research Ltd., Budapest, Hungary) technology is based on a knowledge base approach, where focused libraries around selected cores are used to generate pharmacophore models. NCL was designed on the platform of a diverse kinase inhibitory library organized around 97 core structures. We have established a unique, proprietary kinase inhibitory chemistry around these core structures with small focused sublibraries around each core. All the compounds in our NCL library are stored in a big unified Structured Query Language database along with their measured and calculated physicochemical and ADME/toxicity (ADMET) properties, together with thousands of molecular descriptors calculated for each compound. Biochemical kinase inhibitory assays on selected, cloned kinase enzymes for a few hundred NCL compound sets can provide sufficient biological data for rational computerized design of new analogues, based on our pharmacophore model-generating 3DNET4W™ QSPAR (quantitative structure–property/activity relationships) approach. Using this pharmacophore modeling approach and the ADMET filters, we can preselect synthesizable compounds for hit-and-lead optimization. Starting from this point and integrating the information from QSPAR, high-quality leads can be generated within a small number of optimization cycles. Applying NCL technology we have developed lead compounds for several validated kinase targets." @default.
• W2070575343 created "2016-06-24" @default.
• W2070575343 creator A5009093201 @default.
• W2070575343 creator A5021796062 @default.
• W2070575343 creator A5021976747 @default.
• W2070575343 creator A5023259591 @default.
• W2070575343 creator A5024269757 @default.
• W2070575343 creator A5025613561 @default.
• W2070575343 creator A5029381999 @default.
• W2070575343 creator A5032810572 @default.
• W2070575343 creator A5033265427 @default.
• W2070575343 creator A5033375170 @default.
• W2070575343 creator A5039321576 @default.
• W2070575343 creator A5041096747 @default.
• W2070575343 creator A5045763499 @default.
• W2070575343 creator A5047665746 @default.
• W2070575343 creator A5059315217 @default.
• W2070575343 creator A5073849664 @default.
• W2070575343 creator A5077412380 @default.
• W2070575343 creator A5082916013 @default.
• W2070575343 creator A5089066453 @default.
• W2070575343 creator A5090328045 @default.
• W2070575343 creator A5091770704 @default.
• W2070575343 date "2005-10-01" @default.
• W2070575343 modified "2023-10-18" @default.
• W2070575343 title "Drug Discovery in the Kinase Inhibitory Field Using the Nested Chemical Library™ Technology" @default.
• W2070575343 cites W120676909 @default.
• W2070575343 cites W1956617330 @default.
• W2070575343 cites W1973734061 @default.
• W2070575343 cites W1987378618 @default.
• W2070575343 cites W1993860023 @default.
• W2070575343 cites W1994499469 @default.
• W2070575343 cites W1998084267 @default.
• W2070575343 cites W2010448953 @default.
• W2070575343 cites W2011549571 @default.
• W2070575343 cites W2016452487 @default.
• W2070575343 cites W2031903231 @default.
• W2070575343 cites W2047831202 @default.
• W2070575343 cites W2071007558 @default.
• W2070575343 cites W2087076003 @default.
• W2070575343 cites W2090505088 @default.
• W2070575343 cites W2105341103 @default.
• W2070575343 cites W2117170820 @default.
• W2070575343 cites W2118192897 @default.
• W2070575343 cites W2134755472 @default.
• W2070575343 cites W2134906181 @default.
• W2070575343 cites W2134976703 @default.
• W2070575343 cites W2141634655 @default.
• W2070575343 cites W2146163661 @default.
• W2070575343 cites W2147012175 @default.
• W2070575343 cites W2179558741 @default.
• W2070575343 cites W2180587971 @default.
• W2070575343 cites W2911531103 @default.
• W2070575343 cites W4232431760 @default.
• W2070575343 doi "https://doi.org/10.1089/adt.2005.3.543" @default.
• W2070575343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16305311" @default.
• W2070575343 hasPublicationYear "2005" @default.
• W2070575343 type Work @default.
• W2070575343 sameAs 2070575343 @default.
• W2070575343 citedByCount "32" @default.
• W2070575343 countsByYear W20705753432012 @default.
• W2070575343 countsByYear W20705753432013 @default.
• W2070575343 countsByYear W20705753432015 @default.
• W2070575343 countsByYear W20705753432016 @default.
• W2070575343 countsByYear W20705753432017 @default.
• W2070575343 countsByYear W20705753432018 @default.
• W2070575343 countsByYear W20705753432019 @default.
• W2070575343 countsByYear W20705753432023 @default.
• W2070575343 crossrefType "journal-article" @default.
• W2070575343 hasAuthorship W2070575343A5009093201 @default.
• W2070575343 hasAuthorship W2070575343A5021796062 @default.
• W2070575343 hasAuthorship W2070575343A5021976747 @default.
• W2070575343 hasAuthorship W2070575343A5023259591 @default.
• W2070575343 hasAuthorship W2070575343A5024269757 @default.
• W2070575343 hasAuthorship W2070575343A5025613561 @default.
• W2070575343 hasAuthorship W2070575343A5029381999 @default.
• W2070575343 hasAuthorship W2070575343A5032810572 @default.
• W2070575343 hasAuthorship W2070575343A5033265427 @default.
• W2070575343 hasAuthorship W2070575343A5033375170 @default.
• W2070575343 hasAuthorship W2070575343A5039321576 @default.
• W2070575343 hasAuthorship W2070575343A5041096747 @default.
• W2070575343 hasAuthorship W2070575343A5045763499 @default.
• W2070575343 hasAuthorship W2070575343A5047665746 @default.
• W2070575343 hasAuthorship W2070575343A5059315217 @default.
• W2070575343 hasAuthorship W2070575343A5073849664 @default.
• W2070575343 hasAuthorship W2070575343A5077412380 @default.
• W2070575343 hasAuthorship W2070575343A5082916013 @default.
• W2070575343 hasAuthorship W2070575343A5089066453 @default.
• W2070575343 hasAuthorship W2070575343A5090328045 @default.
• W2070575343 hasAuthorship W2070575343A5091770704 @default.
• W2070575343 hasConcept C184235292 @default.
• W2070575343 hasConcept C185592680 @default.
• W2070575343 hasConcept C202751555 @default.
• W2070575343 hasConcept C21951064 @default.
• W2070575343 hasConcept C2777752112 @default.
• W2070575343 hasConcept C41008148 @default.
• W2070575343 hasConcept C55493867 @default.
• W2070575343 hasConcept C56173144 @default.

• next