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• W2070576398 abstract "Genetic studies have reported association of a polyglycine-encoding GGN repeat in exon 1 of the androgen receptor (AR) gene with common human traits. The polyglycine tract is located in the transactivating domain of the AR protein, suggesting an effect of repeat length on receptor function. Here, we compare the functional characteristics of the two most common alleles (23 and 24 repeats) and two extreme alleles (10 and 27 repeats) in a reporter gene assay in HeLa cells. A correlation between the repeat length and AR activity was observed. This is attributable to both a higher protein concentration, determined by ELISA, and a higher per-protein activity of long repeat alleles. Interestingly, protein concentration does not correlate with transcript quantity, determined by real-time PCR assays, and no influence of repeat length on protein stability could be detected in translation inhibition assays. This may suggest that repeat length affects translation efficiency. In conclusion, our data provide evidence of functional differences between the two most common alleles of the AR GGN repeat, supporting its potential role in the development of human traits." @default.
• W2070576398 created "2016-06-24" @default.
• W2070576398 creator A5008405084 @default.
• W2070576398 creator A5018690824 @default.
• W2070576398 creator A5042877889 @default.
• W2070576398 date "2007-07-01" @default.
• W2070576398 modified "2023-10-12" @default.
• W2070576398 title "The two most common alleles of the coding GGN repeat in the androgen receptor gene cause differences in protein function" @default.
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• W2070576398 doi "https://doi.org/10.1677/jme-06-0072" @default.
• W2070576398 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17601880" @default.
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