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• W2070579755 abstract "Purpose: Recent in vivo experiments have showed non-thermal effects of pulsed focused ultrasound (pFUS) on tumor growth delay. This study investigates the application of a clinical 1.5T MR scanner for treatment assessment of prostate tumors after pFUS treatment, which provides a non- invasive and accurate way to measure tumor volume for treatment efficacy evaluation, and also an alternative way for small animal tumor model study that generally requires high-magnetic-field MRI facility (e.g., the Bruker NMR system). Methods: A mouse tumor model was developed by implanting LNCaP tumor cells in nude mice prostates. When tumor volume reached ∼130 mm3 on MRI, mice were randomly assigned into two groups (n=8): (1) pFUS treatment; (2) control. MRI-guided pFUS treatment was performed using InSightec ExAblate 2000 with a 1.5T GE MR scanner. Non-thermal pFUS was delivered for 60 sec per sonication (1MHz; 25W acoustic power; 10% duty cycle, on/off=0.1/0.9 sec). The body temperature was kept <42°C as measured in real-time by MR thermometry. A total of 4– 8 sonications were used to cover the whole tumor target for each animal. Weekly MR scans were performed using 1.5T scanner to monitor the tumor growth. A ring-shape surface coil (3 inches) was used for MR signal detection. T2-weighted MR imaging used fast-recovery fast-spin-echo (FRFSE) sequence with parameters: TR/TE=2200/85ms, NEX=3, matrix=288×288, FOV=7×7 cm2 (resolution=0. 137×0.137mm2), slice thickness=2/1 mm (coronal/axial). Results: Tumor growth delay was quantified using the clinical 1.5T MR scanner after pFUS treatment while normal tumor growth was clearly observed in the control group. A >40% reduction in tumor volume was shown in mice treated with pFUS compared to that for the control mice Conclusion: Clinical 1.5T MRI is able to assess the tumor volume change after pFUS treatment for a small animal model (tumor size: 3–10mm). It may provide an alternative way for treatment assessment for small animal studies. This work is supported by Focused Ultrasound Surgery Foundation, Varian Medical Systems, DOD PC073127 and DOD BC102806." @default.
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• W2070579755 date "2011-06-01" @default.
• W2070579755 modified "2023-10-15" @default.
• W2070579755 title "WE-G-220-07: Treatment Assessment for Pulsed Focused Ultrasound Therapy of Prostate Tumor Using a Clinical 1.5T MRI" @default.
• W2070579755 doi "https://doi.org/10.1118/1.3613456" @default.
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