FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070584691> ?p ?o ?g. }

• W2070584691 endingPage "2762" @default.
• W2070584691 startingPage "2755" @default.
• W2070584691 abstract "SUMMARY The roles of nitric oxide synthase activity (NOS), nitrite and myoglobin (Mb) in the regulation of myocardial function during hypoxia were examined in trout and goldfish, a hypoxia-intolerant and hypoxia-tolerant species, respectively. We measured the effect of NOS inhibition, adrenaline and nitrite on the O2 consumption rate and isometric twitch force development in electrically paced ventricular preparations during hypoxia, and measured O2 affinity and nitrite reductase activity of the purified heart Mbs of both species. Upon hypoxia (9% O2), O2 consumption and developed force decreased in both trout and goldfish myocardium, with trout showing a significant increase in the O2 utilization efficiency, i.e. the ratio of twitch force to O2 consumption, suggesting an increased anaerobic metabolism. NOS inhibition enhanced myocardial O2 consumption and decreased efficiency, indicating that mitochondrial respiration is under a tone of NOS-produced NO. When trout myocardial twitch force and O2 consumption are enhanced by adrenaline, this NO tone disappears. Consistent with its conversion to NO, nitrite reduced O2 consumption and increased myocardial efficiency in trout but not in goldfish. Such a difference correlates with the lower O2 affinity measured for trout Mb that would increase the fraction of deoxygenated heme available to catalyze the reduction of nitrite to NO. Whereas low-affinity trout Mb would favor O2 diffusion within cardiomyocytes at high in vivo O2 tensions, goldfish Mb having higher O2 affinity and higher nitrite reductase activity appears better suited to facilitate O2 diffusion and nitrite reduction in the heart during severe hypoxia, a condition particularly well tolerated by this species." @default.
• W2070584691 created "2016-06-24" @default.
• W2070584691 creator A5027030296 @default.
• W2070584691 creator A5041477250 @default.
• W2070584691 creator A5046788902 @default.
• W2070584691 creator A5063994789 @default.
• W2070584691 creator A5066210680 @default.
• W2070584691 date "2010-08-15" @default.
• W2070584691 modified "2023-10-02" @default.
• W2070584691 title "Roles of nitric oxide, nitrite and myoglobin on myocardial efficiency in trout (<i>Oncorhynchus mykiss</i>) and goldfish (<i>Carassius auratus</i>): implications for hypoxia tolerance" @default.
• W2070584691 cites W143069765 @default.
• W2070584691 cites W1528220495 @default.
• W2070584691 cites W1780135617 @default.
• W2070584691 cites W1906171535 @default.
• W2070584691 cites W1916285502 @default.
• W2070584691 cites W1955316225 @default.
• W2070584691 cites W1964283706 @default.
• W2070584691 cites W1979109267 @default.
• W2070584691 cites W2013105387 @default.
• W2070584691 cites W2014934108 @default.
• W2070584691 cites W2017907872 @default.
• W2070584691 cites W2021952329 @default.
• W2070584691 cites W2025407784 @default.
• W2070584691 cites W2031769120 @default.
• W2070584691 cites W2033465619 @default.
• W2070584691 cites W2047545717 @default.
• W2070584691 cites W2048626265 @default.
• W2070584691 cites W2050824263 @default.
• W2070584691 cites W2051630798 @default.
• W2070584691 cites W2057813936 @default.
• W2070584691 cites W2058162461 @default.
• W2070584691 cites W2078102632 @default.
• W2070584691 cites W2083809966 @default.
• W2070584691 cites W2096118264 @default.
• W2070584691 cites W2104194825 @default.
• W2070584691 cites W2110639621 @default.
• W2070584691 cites W2120714892 @default.
• W2070584691 cites W2123032544 @default.
• W2070584691 cites W2123971049 @default.
• W2070584691 cites W2127992496 @default.
• W2070584691 cites W2139921047 @default.
• W2070584691 cites W2146987125 @default.
• W2070584691 cites W2151878757 @default.
• W2070584691 cites W2181922237 @default.
• W2070584691 doi "https://doi.org/10.1242/jeb.041624" @default.
• W2070584691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20675545" @default.
• W2070584691 hasPublicationYear "2010" @default.
• W2070584691 type Work @default.
• W2070584691 sameAs 2070584691 @default.
• W2070584691 citedByCount "51" @default.
• W2070584691 countsByYear W20705846912012 @default.
• W2070584691 countsByYear W20705846912013 @default.
• W2070584691 countsByYear W20705846912014 @default.
• W2070584691 countsByYear W20705846912015 @default.
• W2070584691 countsByYear W20705846912016 @default.
• W2070584691 countsByYear W20705846912017 @default.
• W2070584691 countsByYear W20705846912018 @default.
• W2070584691 countsByYear W20705846912019 @default.
• W2070584691 countsByYear W20705846912020 @default.
• W2070584691 countsByYear W20705846912021 @default.
• W2070584691 countsByYear W20705846912022 @default.
• W2070584691 countsByYear W20705846912023 @default.
• W2070584691 crossrefType "journal-article" @default.
• W2070584691 hasAuthorship W2070584691A5027030296 @default.
• W2070584691 hasAuthorship W2070584691A5041477250 @default.
• W2070584691 hasAuthorship W2070584691A5046788902 @default.
• W2070584691 hasAuthorship W2070584691A5063994789 @default.
• W2070584691 hasAuthorship W2070584691A5066210680 @default.
• W2070584691 hasConcept C126322002 @default.
• W2070584691 hasConcept C134018914 @default.
• W2070584691 hasConcept C178790620 @default.
• W2070584691 hasConcept C185592680 @default.
• W2070584691 hasConcept C18903297 @default.
• W2070584691 hasConcept C2776179834 @default.
• W2070584691 hasConcept C2776384668 @default.
• W2070584691 hasConcept C2777622882 @default.
• W2070584691 hasConcept C2778063876 @default.
• W2070584691 hasConcept C2779363728 @default.
• W2070584691 hasConcept C2781341435 @default.
• W2070584691 hasConcept C2909208804 @default.
• W2070584691 hasConcept C505870484 @default.
• W2070584691 hasConcept C519581460 @default.
• W2070584691 hasConcept C540031477 @default.
• W2070584691 hasConcept C55493867 @default.
• W2070584691 hasConcept C71924100 @default.
• W2070584691 hasConcept C7836513 @default.
• W2070584691 hasConcept C86803240 @default.
• W2070584691 hasConceptScore W2070584691C126322002 @default.
• W2070584691 hasConceptScore W2070584691C134018914 @default.
• W2070584691 hasConceptScore W2070584691C178790620 @default.
• W2070584691 hasConceptScore W2070584691C185592680 @default.
• W2070584691 hasConceptScore W2070584691C18903297 @default.
• W2070584691 hasConceptScore W2070584691C2776179834 @default.
• W2070584691 hasConceptScore W2070584691C2776384668 @default.
• W2070584691 hasConceptScore W2070584691C2777622882 @default.
• W2070584691 hasConceptScore W2070584691C2778063876 @default.
• W2070584691 hasConceptScore W2070584691C2779363728 @default.
• W2070584691 hasConceptScore W2070584691C2781341435 @default.

• next