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- W2070590904 abstract "Sachse A, Leike J, Röβling G, Wagner S, Krause W. Preparation and evaluation of lyophilized iopromide-carrying liposomes for liver tumor detection. Invest Radiol 1993;28:838-844. rationale and objectives. The objective of the present investigation was to demonstrate a new method for the production of iopromide-carrying liposomes. We studied biodistribution and elimination behavior, as well as the computed tomography (CT) liver imaging properties. methods. Iopromide-containing liposomes were prepared by the ethanol evaporation method and subsequently lyophilized. The resuspended liposomes were tested in rats and rabbits. results. After resuspension, liposomes with a mean diameter of 467 ± 66 nm and an encapsulation rate of 41.5 ± 5.5% were obtained. In rats, a marked accumulation of liposomal iopromide was found in the liver and spleen. In rabbits, complete renal elimination of iopromide within 7 days was demonstrated. At a dose of 150 mg total iodine/kg, a small tumor (<0.5 cm) could be detected in a VX-2-bearing rabbit. conclusions. The ethanol evaporation method proved to be suitable for the reproducible large-scale manufacture of iopromide liposomes with high encapsulation. The resuspended liposomes displayed favorable biodistribution, elimination and imaging characteristics." @default.
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- W2070590904 date "1993-09-01" @default.
- W2070590904 modified "2023-09-25" @default.
- W2070590904 title "Preparation and Evaluation of Lyophilized Iopromide-Carrying Liposomes for Liver Tumor Detection" @default.
- W2070590904 doi "https://doi.org/10.1097/00004424-199309000-00019" @default.
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