FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070591736> ?p ?o ?g. }

• W2070591736 endingPage "11999" @default.
• W2070591736 startingPage "11994" @default.
• W2070591736 abstract "The ten-eleven translocation 1 (TET1) gene is the founding member of the TET family of enzymes (TET1/2/3) that convert 5-methylcytosine to 5-hydroxymethylcytosine. Although TET1 was first identified as a fusion partner of the mixed lineage leukemia (MLL) gene in acute myeloid leukemia carrying t(10,11), its definitive role in leukemia is unclear. In contrast to the frequent down-regulation (or loss-of-function mutations) and critical tumor-suppressor roles of the three TET genes observed in various types of cancers, here we show that TET1 is a direct target of MLL-fusion proteins and is significantly up-regulated in MLL-rearranged leukemia, leading to a global increase of 5-hydroxymethylcytosine level. Furthermore, our both in vitro and in vivo functional studies demonstrate that Tet1 plays an indispensable oncogenic role in the development of MLL-rearranged leukemia, through coordination with MLL-fusion proteins in regulating their critical cotargets, including homeobox A9 (Hoxa9)/myeloid ecotropic viral integration 1 (Meis1)/pre-B-cell leukemia homeobox 3 (Pbx3) genes. Collectively, our data delineate an MLL-fusion/Tet1/Hoxa9/Meis1/Pbx3 signaling axis in MLL-rearranged leukemia and highlight TET1 as a potential therapeutic target in treating this presently therapy-resistant disease." @default.
• W2070591736 created "2016-06-24" @default.
• W2070591736 creator A5000842818 @default.
• W2070591736 creator A5002649440 @default.
• W2070591736 creator A5004347976 @default.
• W2070591736 creator A5006812383 @default.
• W2070591736 creator A5007179048 @default.
• W2070591736 creator A5008192062 @default.
• W2070591736 creator A5014353611 @default.
• W2070591736 creator A5015211563 @default.
• W2070591736 creator A5015512950 @default.
• W2070591736 creator A5015854826 @default.
• W2070591736 creator A5016359984 @default.
• W2070591736 creator A5021776650 @default.
• W2070591736 creator A5032528040 @default.
• W2070591736 creator A5033704013 @default.
• W2070591736 creator A5034176758 @default.
• W2070591736 creator A5034357519 @default.
• W2070591736 creator A5035262200 @default.
• W2070591736 creator A5039869995 @default.
• W2070591736 creator A5042079141 @default.
• W2070591736 creator A5051480539 @default.
• W2070591736 creator A5053091431 @default.
• W2070591736 creator A5057326412 @default.
• W2070591736 creator A5057367811 @default.
• W2070591736 creator A5059085140 @default.
• W2070591736 creator A5062518186 @default.
• W2070591736 creator A5081832913 @default.
• W2070591736 creator A5087185533 @default.
• W2070591736 creator A5088292023 @default.
• W2070591736 creator A5091114864 @default.
• W2070591736 date "2013-07-01" @default.
• W2070591736 modified "2023-10-08" @default.
• W2070591736 title "<i>TET1</i> plays an essential oncogenic role in <i>MLL</i> -rearranged leukemia" @default.
• W2070591736 cites W1492600479 @default.
• W2070591736 cites W1625536075 @default.
• W2070591736 cites W1970145665 @default.
• W2070591736 cites W1974006411 @default.
• W2070591736 cites W1975764660 @default.
• W2070591736 cites W1976573435 @default.
• W2070591736 cites W1979024008 @default.
• W2070591736 cites W1981463058 @default.
• W2070591736 cites W1984008787 @default.
• W2070591736 cites W1988345778 @default.
• W2070591736 cites W1990689143 @default.
• W2070591736 cites W1997453048 @default.
• W2070591736 cites W2004690859 @default.
• W2070591736 cites W2005458309 @default.
• W2070591736 cites W2006131936 @default.
• W2070591736 cites W2014623973 @default.
• W2070591736 cites W2020016210 @default.
• W2070591736 cites W2021486899 @default.
• W2070591736 cites W2028078153 @default.
• W2070591736 cites W2029746613 @default.
• W2070591736 cites W2030406772 @default.
• W2070591736 cites W2032882684 @default.
• W2070591736 cites W2038449573 @default.
• W2070591736 cites W2043472013 @default.
• W2070591736 cites W2048613921 @default.
• W2070591736 cites W2051888282 @default.
• W2070591736 cites W2056903026 @default.
• W2070591736 cites W2063738914 @default.
• W2070591736 cites W2068050716 @default.
• W2070591736 cites W2069918359 @default.
• W2070591736 cites W2072177644 @default.
• W2070591736 cites W2072713007 @default.
• W2070591736 cites W2073652391 @default.
• W2070591736 cites W2073872690 @default.
• W2070591736 cites W2077359452 @default.
• W2070591736 cites W2077530603 @default.
• W2070591736 cites W2080365007 @default.
• W2070591736 cites W2082592723 @default.
• W2070591736 cites W2088708165 @default.
• W2070591736 cites W2097743943 @default.
• W2070591736 cites W2104910696 @default.
• W2070591736 cites W2105740818 @default.
• W2070591736 cites W2108664872 @default.
• W2070591736 cites W2110726136 @default.
• W2070591736 cites W2116205277 @default.
• W2070591736 cites W2118272259 @default.
• W2070591736 cites W2118985891 @default.
• W2070591736 cites W2123139937 @default.
• W2070591736 cites W2125386151 @default.
• W2070591736 cites W2126235341 @default.
• W2070591736 cites W2138472595 @default.
• W2070591736 cites W2145534945 @default.
• W2070591736 cites W2152333235 @default.
• W2070591736 cites W2152636479 @default.
• W2070591736 cites W2157646587 @default.
• W2070591736 cites W2158773950 @default.
• W2070591736 cites W2161879531 @default.
• W2070591736 cites W2164305025 @default.
• W2070591736 cites W2165361270 @default.
• W2070591736 doi "https://doi.org/10.1073/pnas.1310656110" @default.
• W2070591736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3718141" @default.
• W2070591736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23818607" @default.
• W2070591736 hasPublicationYear "2013" @default.
• W2070591736 type Work @default.

• next