Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070593887> ?p ?o ?g. }
- W2070593887 endingPage "541" @default.
- W2070593887 startingPage "528" @default.
- W2070593887 abstract "Multiple conserved mechanisms sense nutritional conditions and coordinate metabolic changes in the whole organism. We unravel a role for the Drosophila homolog of p53 (Dp53) in the fat body (FB; a functional analog of vertebrate adipose and hepatic tissues) in starvation adaptation. Under nutrient deprivation, FB-specific depletion of Dp53 accelerates consumption of major energy stores and reduces survival rates of adult flies. We show that Dp53 is regulated by the microRNA (miRNA) machinery and miR-305 in a nutrition-dependent manner. In well-fed animals, TOR signaling contributes to miR-305-mediated inhibition of Dp53. Nutrient deprivation reduces the levels of miRNA machinery components and leads to Dp53 derepression. Our results uncover an organism-wide role for Dp53 in nutrient sensing and metabolic adaptation and open up avenues toward understanding the molecular mechanisms underlying p53 activation under nutrient deprivation." @default.
- W2070593887 created "2016-06-24" @default.
- W2070593887 creator A5012123674 @default.
- W2070593887 creator A5036074218 @default.
- W2070593887 creator A5056127134 @default.
- W2070593887 date "2014-07-01" @default.
- W2070593887 modified "2023-10-01" @default.
- W2070593887 title "MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation" @default.
- W2070593887 cites W1785740069 @default.
- W2070593887 cites W1965495036 @default.
- W2070593887 cites W1967419651 @default.
- W2070593887 cites W1970431885 @default.
- W2070593887 cites W1972597570 @default.
- W2070593887 cites W1974161033 @default.
- W2070593887 cites W1980181091 @default.
- W2070593887 cites W1980269624 @default.
- W2070593887 cites W1984755213 @default.
- W2070593887 cites W1987942547 @default.
- W2070593887 cites W1990130829 @default.
- W2070593887 cites W1990992599 @default.
- W2070593887 cites W1991510903 @default.
- W2070593887 cites W1998192361 @default.
- W2070593887 cites W2003369513 @default.
- W2070593887 cites W2007636825 @default.
- W2070593887 cites W2010461414 @default.
- W2070593887 cites W2011055466 @default.
- W2070593887 cites W2014758663 @default.
- W2070593887 cites W2022839356 @default.
- W2070593887 cites W2025476423 @default.
- W2070593887 cites W2039415806 @default.
- W2070593887 cites W2043107604 @default.
- W2070593887 cites W2046930479 @default.
- W2070593887 cites W2051178873 @default.
- W2070593887 cites W2058326304 @default.
- W2070593887 cites W2062793520 @default.
- W2070593887 cites W2082969207 @default.
- W2070593887 cites W2096628067 @default.
- W2070593887 cites W2098646234 @default.
- W2070593887 cites W2104694670 @default.
- W2070593887 cites W2107498496 @default.
- W2070593887 cites W2110643873 @default.
- W2070593887 cites W2112743993 @default.
- W2070593887 cites W2114713612 @default.
- W2070593887 cites W2117275311 @default.
- W2070593887 cites W2122826701 @default.
- W2070593887 cites W2128648826 @default.
- W2070593887 cites W2131844826 @default.
- W2070593887 cites W2131989828 @default.
- W2070593887 cites W2141884202 @default.
- W2070593887 cites W2148070562 @default.
- W2070593887 cites W2150703531 @default.
- W2070593887 cites W2154260730 @default.
- W2070593887 cites W2160652283 @default.
- W2070593887 cites W2165192354 @default.
- W2070593887 cites W2166086263 @default.
- W2070593887 cites W2166264560 @default.
- W2070593887 doi "https://doi.org/10.1016/j.celrep.2014.06.020" @default.
- W2070593887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25017064" @default.
- W2070593887 hasPublicationYear "2014" @default.
- W2070593887 type Work @default.
- W2070593887 sameAs 2070593887 @default.
- W2070593887 citedByCount "48" @default.
- W2070593887 countsByYear W20705938872015 @default.
- W2070593887 countsByYear W20705938872016 @default.
- W2070593887 countsByYear W20705938872017 @default.
- W2070593887 countsByYear W20705938872018 @default.
- W2070593887 countsByYear W20705938872019 @default.
- W2070593887 countsByYear W20705938872020 @default.
- W2070593887 countsByYear W20705938872021 @default.
- W2070593887 countsByYear W20705938872022 @default.
- W2070593887 countsByYear W20705938872023 @default.
- W2070593887 crossrefType "journal-article" @default.
- W2070593887 hasAuthorship W2070593887A5012123674 @default.
- W2070593887 hasAuthorship W2070593887A5036074218 @default.
- W2070593887 hasAuthorship W2070593887A5056127134 @default.
- W2070593887 hasBestOaLocation W20705938871 @default.
- W2070593887 hasConcept C104317684 @default.
- W2070593887 hasConcept C137858568 @default.
- W2070593887 hasConcept C139807058 @default.
- W2070593887 hasConcept C142796444 @default.
- W2070593887 hasConcept C145059251 @default.
- W2070593887 hasConcept C150194340 @default.
- W2070593887 hasConcept C169760540 @default.
- W2070593887 hasConcept C171089720 @default.
- W2070593887 hasConcept C186310378 @default.
- W2070593887 hasConcept C18903297 @default.
- W2070593887 hasConcept C192989942 @default.
- W2070593887 hasConcept C2776030549 @default.
- W2070593887 hasConcept C3018542373 @default.
- W2070593887 hasConcept C54355233 @default.
- W2070593887 hasConcept C55493867 @default.
- W2070593887 hasConcept C62231903 @default.
- W2070593887 hasConcept C62478195 @default.
- W2070593887 hasConcept C73766848 @default.
- W2070593887 hasConcept C86803240 @default.
- W2070593887 hasConcept C95444343 @default.
- W2070593887 hasConceptScore W2070593887C104317684 @default.
- W2070593887 hasConceptScore W2070593887C137858568 @default.