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- W2070594003 abstract "Prostate cancer is the second most common malignancy in males and the leading cause of cancer death. Prostate cancer is initially androgen dependent and relies upon the androgen receptor (AR) to mediate the effects of androgens. The AR is also the target for therapy using antiandrogens and LHRH analogues. However, all cancers eventually become androgen independent, often referred to as hormone refractory prostate cancer. The processes involved in this transformation are yet to be fully understood but research in this area has discovered numerous potential mechanisms including AR amplification, over-expression or mutation and alterations in the AR signaling pathway. This review of the recent literature examines the current knowledge and developments in the understanding of the molecular biology of prostate cancer and hormone refractory prostate cancer, summarizing the well characterized pathways involved as well as introducing new concepts that may offer future solutions to this difficult problem." @default.
- W2070594003 created "2016-06-24" @default.
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- W2070594003 creator A5070068920 @default.
- W2070594003 creator A5082768586 @default.
- W2070594003 creator A5090783984 @default.
- W2070594003 date "2007-01-01" @default.
- W2070594003 modified "2023-10-18" @default.
- W2070594003 title "Pathogenesis of prostate cancer and hormone refractory prostate cancer" @default.
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- W2070594003 doi "https://doi.org/10.4103/0970-1591.30265" @default.
- W2070594003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2721494" @default.
- W2070594003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19675761" @default.
- W2070594003 hasPublicationYear "2007" @default.
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