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- W2070596988 abstract "ABSTRACT In relation to emerging multiresistant bacteria, development of antimicrobials and new treatment strategies of infections should be expected to become a high-priority research area. Quorum sensing (QS), a communication system used by pathogenic bacteria like Pseudomonas aeruginosa to synchronize the expression of specific genes involved in pathogenicity, is a possible drug target. Previous in vitro and in vivo studies revealed a significant inhibition of P. aeruginosa QS by crude garlic extract. By bioassay-guided fractionation of garlic extracts, we determined the primary QS inhibitor present in garlic to be ajoene, a sulfur-containing compound with potential as an antipathogenic drug. By comprehensive in vitro and in vivo studies, the effect of synthetic ajoene toward P. aeruginosa was elucidated. DNA microarray studies of ajoene-treated P. aeruginosa cultures revealed a concentration-dependent attenuation of a few but central QS-controlled virulence factors, including rhamnolipid. Furthermore, ajoene treatment of in vitro biofilms demonstrated a clear synergistic, antimicrobial effect with tobramycin on biofilm killing and a cease in lytic necrosis of polymorphonuclear leukocytes. Furthermore, in a mouse model of pulmonary infection, a significant clearing of infecting P. aeruginosa was detected in ajoene-treated mice compared to a nontreated control group. This study adds to the list of examples demonstrating the potential of QS-interfering compounds in the treatment of bacterial infections." @default.
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- W2070596988 date "2012-05-01" @default.
- W2070596988 modified "2023-10-18" @default.
- W2070596988 title "Ajoene, a Sulfur-Rich Molecule from Garlic, Inhibits Genes Controlled by Quorum Sensing" @default.
- W2070596988 cites W1493719871 @default.
- W2070596988 cites W1560681583 @default.
- W2070596988 cites W1699562064 @default.
- W2070596988 cites W1853571779 @default.
- W2070596988 cites W1907600034 @default.
- W2070596988 cites W1924990972 @default.
- W2070596988 cites W1943112463 @default.
- W2070596988 cites W1965538842 @default.
- W2070596988 cites W1970650417 @default.
- W2070596988 cites W1977105094 @default.
- W2070596988 cites W1980423687 @default.
- W2070596988 cites W1987882477 @default.
- W2070596988 cites W1991795415 @default.
- W2070596988 cites W1994053088 @default.
- W2070596988 cites W1995756058 @default.
- W2070596988 cites W2007293232 @default.
- W2070596988 cites W2011458493 @default.
- W2070596988 cites W2011599312 @default.
- W2070596988 cites W2021225164 @default.
- W2070596988 cites W2025704800 @default.
- W2070596988 cites W2027459239 @default.
- W2070596988 cites W2037411053 @default.
- W2070596988 cites W2040014098 @default.
- W2070596988 cites W2044913844 @default.
- W2070596988 cites W2049857963 @default.
- W2070596988 cites W2053460725 @default.
- W2070596988 cites W2061520106 @default.
- W2070596988 cites W2064612941 @default.
- W2070596988 cites W2069962023 @default.
- W2070596988 cites W2072936433 @default.
- W2070596988 cites W2073904950 @default.
- W2070596988 cites W2074779228 @default.
- W2070596988 cites W2077006329 @default.
- W2070596988 cites W2078996907 @default.
- W2070596988 cites W2079698171 @default.
- W2070596988 cites W2080380609 @default.
- W2070596988 cites W2084218797 @default.
- W2070596988 cites W2085222365 @default.
- W2070596988 cites W2101380390 @default.
- W2070596988 cites W2104462602 @default.
- W2070596988 cites W2111678991 @default.
- W2070596988 cites W2111756873 @default.
- W2070596988 cites W2114437252 @default.
- W2070596988 cites W2114671816 @default.
- W2070596988 cites W2119410664 @default.
- W2070596988 cites W2125603952 @default.
- W2070596988 cites W2128110165 @default.
- W2070596988 cites W2129365470 @default.
- W2070596988 cites W2130547438 @default.
- W2070596988 cites W2131903790 @default.
- W2070596988 cites W2142424945 @default.
- W2070596988 cites W2142919688 @default.
- W2070596988 cites W2143907723 @default.
- W2070596988 cites W2144440398 @default.
- W2070596988 cites W2144562098 @default.
- W2070596988 cites W2145402561 @default.
- W2070596988 cites W2146292204 @default.
- W2070596988 cites W2151399020 @default.
- W2070596988 cites W2154447238 @default.
- W2070596988 cites W2154562589 @default.
- W2070596988 cites W2162427999 @default.
- W2070596988 cites W2165707370 @default.
- W2070596988 cites W2165850276 @default.
- W2070596988 cites W2166615477 @default.
- W2070596988 cites W2166740816 @default.
- W2070596988 cites W2167307872 @default.
- W2070596988 cites W2167416971 @default.
- W2070596988 cites W2171527366 @default.
- W2070596988 cites W2307231383 @default.
- W2070596988 cites W2321995885 @default.
- W2070596988 cites W4213354399 @default.
- W2070596988 cites W4231863947 @default.
- W2070596988 cites W4247205340 @default.
- W2070596988 doi "https://doi.org/10.1128/aac.05919-11" @default.