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- W2070604422 endingPage "431" @default.
- W2070604422 startingPage "419" @default.
- W2070604422 abstract "Surrogate endpoints are important for validation of mechanism, early proof of concept, and the rational design of clinical trials for regulatory approval of drugs. The recent failure of several drugs in peripheral arterial disease (PAD) and in atherosclerosis highlights the importance of understanding drug effect and is a clarion call for better endpoints. This review focuses on aspects relating to the current state of surrogate endpoints in PAD and reviews emerging endpoints using imaging approaches that may have the potential of improving study design in PAD." @default.
- W2070604422 created "2016-06-24" @default.
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- W2070604422 date "2011-08-01" @default.
- W2070604422 modified "2023-10-06" @default.
- W2070604422 title "Perspectives on Optimizing Trial Design and Endpoints in Peripheral Arterial Disease: A Case for Imaging-Based Surrogates as Endpoints of Functional Efficacy" @default.
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- W2070604422 doi "https://doi.org/10.1016/j.ccl.2011.04.002" @default.
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