FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070610367> ?p ?o ?g. }

• W2070610367 endingPage "1291" @default.
• W2070610367 startingPage "1283" @default.
• W2070610367 abstract "Objective: To investigate the effect of a short course of HAART during primary HIV infection (PHI) on rate of CD4 cell and viral load change. Methods: Data following HAART cessation from 89 individuals (seroconverting 1999–2003) who chose to take a 3 month course of HAART at PHI were compared with 179 untreated controls in CASCADE, using linear and nonlinear random effects models. Participants were non-randomized but frequency matched for age, sex, risk factor, year of seroconversion and presentation within the first 6 months of seroconversion. Time to CD4 cell count < 350 cells/μl and initiation of clinically indicated antiretroviral therapy (ART) were also compared as competing risks. Results: The rate of CD4 cell decline following therapy cessation appeared significantly slower among treated participants than untreated controls: losses of 51 cells/μl [95% confidence interval (CI), 32–69] and 77 cells/μl (95% CI, 65–89), respectively, 3 years after seroconversion (P = 0.011). Based on extrapolated data, viral loads also differed significantly at this point (4.09 and 4.53 copies/ml, respectively). At 2 years, there was no significant difference in mean viral load levels: 4.31 copies/ml (95% CI, 4.14–4.48) and 4.47 copies/ml (95% CI, 4.28–4.66), respectively. CASCADE seroconverters were more likely to reach CD4 cell count < 350 cells/μl or initiate clinically indicated ART (hazard ratio, 1.45; 95% CI, 1.02–2.05; P = 0.039). Conclusion: A short course of ART at PHI may delay CD4 cell decline. Confirmation of this requires a randomized clinical trial powered to address definitively the role of ART intervention in PHI (currently underway through SPARTAC)." @default.
• W2070610367 created "2016-06-24" @default.
• W2070610367 creator A5011731216 @default.
• W2070610367 creator A5026739355 @default.
• W2070610367 creator A5029861967 @default.
• W2070610367 creator A5051791661 @default.
• W2070610367 creator A5053100916 @default.
• W2070610367 creator A5067056877 @default.
• W2070610367 creator A5068835724 @default.
• W2070610367 date "2007-06-01" @default.
• W2070610367 modified "2023-09-22" @default.
• W2070610367 title "Slower CD4 cell decline following cessation of a 3 month course of HAART in primary HIV infection: findings from an observational cohort" @default.
• W2070610367 cites W1562214598 @default.
• W2070610367 cites W1815763197 @default.
• W2070610367 cites W1982448824 @default.
• W2070610367 cites W1988933769 @default.
• W2070610367 cites W1990659001 @default.
• W2070610367 cites W1998186572 @default.
• W2070610367 cites W2011541285 @default.
• W2070610367 cites W2011630381 @default.
• W2070610367 cites W2020096299 @default.
• W2070610367 cites W2022211849 @default.
• W2070610367 cites W2036652038 @default.
• W2070610367 cites W2037343680 @default.
• W2070610367 cites W2038981426 @default.
• W2070610367 cites W2040458628 @default.
• W2070610367 cites W2045551237 @default.
• W2070610367 cites W2055350602 @default.
• W2070610367 cites W2059137856 @default.
• W2070610367 cites W2060829964 @default.
• W2070610367 cites W2061724579 @default.
• W2070610367 cites W2063485002 @default.
• W2070610367 cites W2064152453 @default.
• W2070610367 cites W2081550246 @default.
• W2070610367 cites W2082246284 @default.
• W2070610367 cites W2095983332 @default.
• W2070610367 cites W2099050891 @default.
• W2070610367 cites W2108603500 @default.
• W2070610367 cites W2131099542 @default.
• W2070610367 cites W2145004838 @default.
• W2070610367 cites W2148132203 @default.
• W2070610367 cites W2149730509 @default.
• W2070610367 cites W2154533921 @default.
• W2070610367 cites W2159638385 @default.
• W2070610367 cites W2160538807 @default.
• W2070610367 cites W2160594014 @default.
• W2070610367 cites W2168776079 @default.
• W2070610367 cites W2172042588 @default.
• W2070610367 cites W2309506771 @default.
• W2070610367 cites W3028305921 @default.
• W2070610367 doi "https://doi.org/10.1097/qad.0b013e3280b07b5b" @default.
• W2070610367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17545704" @default.
• W2070610367 hasPublicationYear "2007" @default.
• W2070610367 type Work @default.
• W2070610367 sameAs 2070610367 @default.
• W2070610367 citedByCount "28" @default.
• W2070610367 countsByYear W20706103672012 @default.
• W2070610367 countsByYear W20706103672013 @default.
• W2070610367 countsByYear W20706103672014 @default.
• W2070610367 countsByYear W20706103672016 @default.
• W2070610367 countsByYear W20706103672018 @default.
• W2070610367 countsByYear W20706103672019 @default.
• W2070610367 crossrefType "journal-article" @default.
• W2070610367 hasAuthorship W2070610367A5011731216 @default.
• W2070610367 hasAuthorship W2070610367A5026739355 @default.
• W2070610367 hasAuthorship W2070610367A5029861967 @default.
• W2070610367 hasAuthorship W2070610367A5051791661 @default.
• W2070610367 hasAuthorship W2070610367A5053100916 @default.
• W2070610367 hasAuthorship W2070610367A5067056877 @default.
• W2070610367 hasAuthorship W2070610367A5068835724 @default.
• W2070610367 hasBestOaLocation W20706103671 @default.
• W2070610367 hasConcept C126322002 @default.
• W2070610367 hasConcept C142462285 @default.
• W2070610367 hasConcept C201903717 @default.
• W2070610367 hasConcept C203014093 @default.
• W2070610367 hasConcept C207103383 @default.
• W2070610367 hasConcept C2777451964 @default.
• W2070610367 hasConcept C2993143319 @default.
• W2070610367 hasConcept C3013748606 @default.
• W2070610367 hasConcept C44249647 @default.
• W2070610367 hasConcept C50382708 @default.
• W2070610367 hasConcept C50440223 @default.
• W2070610367 hasConcept C71924100 @default.
• W2070610367 hasConcept C72563966 @default.
• W2070610367 hasConcept C90924648 @default.
• W2070610367 hasConceptScore W2070610367C126322002 @default.
• W2070610367 hasConceptScore W2070610367C142462285 @default.
• W2070610367 hasConceptScore W2070610367C201903717 @default.
• W2070610367 hasConceptScore W2070610367C203014093 @default.
• W2070610367 hasConceptScore W2070610367C207103383 @default.
• W2070610367 hasConceptScore W2070610367C2777451964 @default.
• W2070610367 hasConceptScore W2070610367C2993143319 @default.
• W2070610367 hasConceptScore W2070610367C3013748606 @default.
• W2070610367 hasConceptScore W2070610367C44249647 @default.
• W2070610367 hasConceptScore W2070610367C50382708 @default.
• W2070610367 hasConceptScore W2070610367C50440223 @default.
• W2070610367 hasConceptScore W2070610367C71924100 @default.
• W2070610367 hasConceptScore W2070610367C72563966 @default.

• next