Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070618589> ?p ?o ?g. }
- W2070618589 endingPage "8" @default.
- W2070618589 startingPage "1" @default.
- W2070618589 abstract "Targeting of immune cells by bispecific antibodies has proven a powerful tool for the investigation of cellular cytotoxicity, lymphocyte activation and induction of cytokine production, as well as to represent an innovative form of immunotherapy for the treatment of cancer. The hallmark of this approach is the use of the specificity of monoclonal antibodies to join target and immune cells by virtue of the dual specificity of bispecific antibodies for the two entities. More precisely the bispecific antibody has two different binding sites, which are capable of recognizing tumor associated antigens on the one hand and lymphocyte activation sites on the other. This process of crosslinking results in the activation of the lymphocyte and triggering of its lytic machinery, as well as lymphokine production. A major advantage of this therapeutic modality is, that use is made of the normal cellular immune defence system and therefore is only associated with minor toxicity. The distinct lymphocyte populations, which can be used for adoptive immunotherapy and the various bispecific antibody preparations, as well as the chimeric immunoglobulin/T cell receptor construction are the major topics of this review." @default.
- W2070618589 created "2016-06-24" @default.
- W2070618589 creator A5010553869 @default.
- W2070618589 creator A5053450172 @default.
- W2070618589 creator A5070370737 @default.
- W2070618589 date "1991-01-01" @default.
- W2070618589 modified "2023-09-23" @default.
- W2070618589 title "T cell targeting in cancer therapy" @default.
- W2070618589 cites W1447837928 @default.
- W2070618589 cites W1480489408 @default.
- W2070618589 cites W1483194800 @default.
- W2070618589 cites W1484112158 @default.
- W2070618589 cites W1497645790 @default.
- W2070618589 cites W1501034910 @default.
- W2070618589 cites W1550812089 @default.
- W2070618589 cites W1555293080 @default.
- W2070618589 cites W1556867369 @default.
- W2070618589 cites W1565218273 @default.
- W2070618589 cites W1568056581 @default.
- W2070618589 cites W1573797130 @default.
- W2070618589 cites W1579000294 @default.
- W2070618589 cites W1584268075 @default.
- W2070618589 cites W1591949965 @default.
- W2070618589 cites W1593533610 @default.
- W2070618589 cites W1599880469 @default.
- W2070618589 cites W1626950098 @default.
- W2070618589 cites W1654364508 @default.
- W2070618589 cites W167027881 @default.
- W2070618589 cites W1694911628 @default.
- W2070618589 cites W1754939372 @default.
- W2070618589 cites W1891455977 @default.
- W2070618589 cites W1906464993 @default.
- W2070618589 cites W1918685724 @default.
- W2070618589 cites W1958125141 @default.
- W2070618589 cites W1964264035 @default.
- W2070618589 cites W1965261506 @default.
- W2070618589 cites W1968862323 @default.
- W2070618589 cites W1979233083 @default.
- W2070618589 cites W1981177369 @default.
- W2070618589 cites W1982130633 @default.
- W2070618589 cites W1984961927 @default.
- W2070618589 cites W1986309700 @default.
- W2070618589 cites W1987944286 @default.
- W2070618589 cites W1997486804 @default.
- W2070618589 cites W1998321755 @default.
- W2070618589 cites W1998592323 @default.
- W2070618589 cites W2003624697 @default.
- W2070618589 cites W2007576364 @default.
- W2070618589 cites W2009365160 @default.
- W2070618589 cites W2012618070 @default.
- W2070618589 cites W2012621186 @default.
- W2070618589 cites W2016249716 @default.
- W2070618589 cites W2016620180 @default.
- W2070618589 cites W2017963255 @default.
- W2070618589 cites W2020455973 @default.
- W2070618589 cites W2020851010 @default.
- W2070618589 cites W2020971843 @default.
- W2070618589 cites W2021318893 @default.
- W2070618589 cites W2023236831 @default.
- W2070618589 cites W2025260365 @default.
- W2070618589 cites W2027140056 @default.
- W2070618589 cites W2027984797 @default.
- W2070618589 cites W2028697515 @default.
- W2070618589 cites W2031011895 @default.
- W2070618589 cites W2035651824 @default.
- W2070618589 cites W2036160208 @default.
- W2070618589 cites W2037127970 @default.
- W2070618589 cites W2044911992 @default.
- W2070618589 cites W2047075585 @default.
- W2070618589 cites W2047205338 @default.
- W2070618589 cites W2051344486 @default.
- W2070618589 cites W2053104174 @default.
- W2070618589 cites W2057233688 @default.
- W2070618589 cites W2057784785 @default.
- W2070618589 cites W2058606944 @default.
- W2070618589 cites W2061604045 @default.
- W2070618589 cites W2063495909 @default.
- W2070618589 cites W2065270456 @default.
- W2070618589 cites W2065272367 @default.
- W2070618589 cites W2067640117 @default.
- W2070618589 cites W2068457755 @default.
- W2070618589 cites W2069970568 @default.
- W2070618589 cites W2071286974 @default.
- W2070618589 cites W2071573211 @default.
- W2070618589 cites W2072418891 @default.
- W2070618589 cites W2073475836 @default.
- W2070618589 cites W2076726803 @default.
- W2070618589 cites W2079041842 @default.
- W2070618589 cites W2079588771 @default.
- W2070618589 cites W2080937805 @default.
- W2070618589 cites W2080966713 @default.
- W2070618589 cites W2081570576 @default.
- W2070618589 cites W2088689097 @default.
- W2070618589 cites W2091201553 @default.
- W2070618589 cites W2091757239 @default.
- W2070618589 cites W2094012882 @default.
- W2070618589 cites W2094799089 @default.
- W2070618589 cites W2095213694 @default.