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- W2070619076 endingPage "891" @default.
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- W2070619076 abstract "Administration of either low or high doses of the alpha-2A adrenergic agonist guanfacine (GFC) to aged monkeys has been shown to improve performance of the delayed-response task, a task linked to the dorsolateral prefrontal cortex (dlPFC). Monkeys treated with higher guanfacine doses also appeared less disinhibited, suggesting enhanced ventromedial-orbital PFC (vmPFC) function. To test this hypothesis, the current study examined the effects of low versus high doses of GFC on reversal of a visual object discrimination task, a task particularly sensitive to vmPFC lesions. The results of this study showed that high (0.1 mg/kg) but not low (0.00001-0.001 mg/kg) doses of GFC significantly improved reversal performance in aged monkeys. These results may be relevant to GFC's calming effects in attention deficit hyperactivity disorder." @default.
- W2070619076 created "2016-06-24" @default.
- W2070619076 creator A5019453928 @default.
- W2070619076 creator A5024065366 @default.
- W2070619076 date "1997-01-01" @default.
- W2070619076 modified "2023-09-25" @default.
- W2070619076 title "The α-2A noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys." @default.
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- W2070619076 doi "https://doi.org/10.1037//0735-7044.111.5.883" @default.
- W2070619076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9383511" @default.
- W2070619076 hasPublicationYear "1997" @default.
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