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• W2070621891 abstract "<b>Objectives:</b> To evaluate the effect of ethanolic extract of leaves of <i>Paederia foetida</i> on acetic acid induced colitis in albino rats.<br> <b>Materials and Methods:</b> Ethanolic extract of <i>Paederia foetida</i> (EEPF) was prepared by percolation method. Acute toxicity test was done by using Organization for Economic Cooperation and Development guidelines. Albino rats were divided into four groups of five animals each. Groups A and B received 3% gum acacia. Groups C and D received EEPF 500 mg/kg body weight (BW) and 5-aminosalisylic acid 100 mg/kg BW respectively. Colitis was induced by transrectal administration of 4% acetic acid on 5 ^th day. All animals were sacrificed after 48 h of colitis induction and distal 10 cm of the colon was dissected. Colon was weighed for disease activity index (DAI) and scored macroscopically and microscopically. Biochemical assessment of tissue myeloperoxidase (MPO), catalase (CAT) and superoxide dismutase (SOD) was done in colonic tissue homogenate and malondialdehyde (MDA) was estimated in serum.<br> <b>Results:</b> <i>P. foetida</i> showed significant (<i>P</i> < 0.05) reduction in DAI, macroscopic and microscopic lesion score as well as significant (<i>P </i>< 0.05) improvement in MPO, MDA, CAT, and SOD level as compared to Group B.<br><b>Conclusions:</b> The ethanolic extract of leaves of <i>P. foetida</i> showed significant amelioration of experimentally induced colitis, which may be attributed to its anti-inflammatory and antioxidant property." @default.
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• W2070621891 date "2013-01-01" @default.
• W2070621891 modified "2023-10-06" @default.
• W2070621891 title "Effect of ethanolic extract of leaves of Paederia foetida Linn. on acetic acid induced colitis in albino rats" @default.
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• W2070621891 doi "https://doi.org/10.4103/0253-7613.117728" @default.
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