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• W2070633997 abstract "Protection against Plasmodium falciparum sporozoite infection can be achieved by vaccination with the recombinant circumsporozoite protein-based vaccine RTS,S formulated with the AS02A Adjuvant System. Since this protection is only partial and wanes over time, we have developed a new RTS,S-based vaccine adjuvanted with AS01B. RTS,S/AS01B-induced high specific antibody titers and increased the frequency of mouse CD4(+) and CD8(+) T cells expressing IFN-gamma, and of monkey CD4(+) T cells expressing IL-2 and/or IFN-gamma and/or TNF-alpha upon stimulation with vaccine antigens. Our data provides clear evidence that combining RTS,S antigen with a potent adjuvant induces strong humoral and cellular responses in vivo." @default.
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• W2070633997 date "2008-02-01" @default.
• W2070633997 modified "2023-09-26" @default.
• W2070633997 title "Improved T cell responses to Plasmodium falciparum circumsporozoite protein in mice and monkeys induced by a novel formulation of RTS,S vaccine antigen" @default.
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• W2070633997 doi "https://doi.org/10.1016/j.vaccine.2007.12.018" @default.
• W2070633997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18258343" @default.
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