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- W2070635223 abstract "<h2>Abstract</h2> <i>Background</i>. Use of lungs harvested from non-heart-beating donors (NHBDs) would increase the pulmonary donor pool; however, this strategy would have higher risk of early postoperative graft dysfunction due to unavoidable warm ischemic time. We evaluated the effects of short-term inhaled nitric oxide (NO) during reperfusion in canine left single-lung allotransplantation from a non-heart-beating donor. <i>Methods</i>. The donor dogs were sacrificed without heparinization and left at room temperature for 3 hours. Then, recipient dogs received a left single-lung allotransplantation. After implantation, the right bronchus and pulmonary artery were ligated. In group 1 (n = 6), NO gas was administered continuously at a concentration of 40 parts per million throughout a 6-hour assessment period. In group 2 (n = 6), NO gas was administered for the initial 1 hour during reperfusion. In group 3 (n = 6), nitrogen gas was administered for control. <i>Results</i>. Groups treated with NO exhibited lower pulmonary vascular resistance, as well as improved survival and oxygenation. There was no significant difference in these parameters between group 1 and group 2. Myeloperoxidase activity was significantly lower in NO-treated groups. <i>Conclusions</i>. Inhaled NO during reperfusion is beneficial in lung transplantation from non-beating heart donors. The beneficial effect is obtained mainly during the first hour of reperfusion." @default.
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- W2070635223 date "2000-11-01" @default.
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- W2070635223 title "Short-term inhaled nitric oxide in canine lung transplantation from non-heart-beating donor" @default.
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- W2070635223 doi "https://doi.org/10.1016/s0003-4975(00)01496-x" @default.
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