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• W2070636596 abstract "RGS5, a signalling protein that regulates the activity of G proteins, is shown to be an important regulator of the tumour vasculature. Deletion of Rgs5 leads to normalization of blood vessels of tumours, making them less leaky and improving their coverage with pericytes. As a consequence, more immune cells that can target the tumour cells actually reach the tumour, which enhances the survival of tumour-bearing mice. Thus RGS5 signalling might be a target for anticancer therapy, in particular in combination with approaches that enhance an antitumour immune response. RGS5, a signalling protein that regulates the activity of G proteins, is shown to be an important regulator of the tumour vasculature. Deletion of RGS5 leads to normalization of blood vessels of tumours, making them less leady and improving their coverage with pericytes. As a consequence, more immune cells that can target the tumour cells reach the tumour, which enhances the survival of tumour-bearing mice. The vasculature of solid tumours is morphologically aberrant and characterized by dilated and fragile vessels, intensive vessel sprouting and loss of hierarchical architecture1. Constant vessel remodelling leads to spontaneous haemorrhages2 and increased interstitial fluid pressure in the tumour environment3,4. Tumour-related angiogenesis supports tumour growth and is also a major obstacle for successful immune therapy as it prevents migration of immune effector cells into established tumour parenchyma2,5,6. The molecular mechanisms for these angiogenic alterations are largely unknown. Here we identify regulator of G-protein signalling 5 (Rgs5) as a master gene responsible for the abnormal tumour vascular morphology in mice. Loss of Rgs5 results in pericyte maturation, vascular normalization and consequent marked reductions in tumour hypoxia and vessel leakiness. These vascular and intratumoral changes enhance influx of immune effector cells into tumour parenchyma and markedly prolong survival of tumour-bearing mice. This is the first demonstration, to our knowledge, of reduced tumour angiogenesis and improved immune therapeutic outcome on loss of a vascular gene function and establishes a previously unrecognized role of G-protein signalling in tumour angiogenesis." @default.
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• W2070636596 date "2008-04-16" @default.
• W2070636596 modified "2023-10-12" @default.
• W2070636596 title "Vascular normalization in Rgs5-deficient tumours promotes immune destruction" @default.
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• W2070636596 doi "https://doi.org/10.1038/nature06868" @default.
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