FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070640326> ?p ?o ?g. }

• W2070640326 endingPage "270" @default.
• W2070640326 startingPage "263" @default.
• W2070640326 abstract "Helicobacter pylori causes gastritis, peptic ulcer disease and gastric cancer. The microbe is found in the gastric mucus layer where a pH gradient ranging from acidic in the lumen to neutral at the cell surface is maintained. The aim of the present study was to investigate the effects of pH on H. pylori binding to gastric mucins from healthy individuals. At pH 3, all strains bound to the most charged MUC5AC glycoform and to a putative mucin of higher charge and larger size than subunits of MUC5AC and MUC6, irrespective of host blood-group. In contrast, at pH 7.4 only Leb-binding BabA-positive strains bound to Leb-positive MUC5AC and to smaller mucin-like molecules, including MUC1. H. pylori binding to the latter component(s) seems to occur via the H-type-1 structure. All strains bound to a proteoglycan containing chondroitin sulphate/dermatan sulphate side chains at acidic pH, whereas binding to secreted MUC5AC and putative membrane-bound strains occurred both at neutral and acidic pH. The binding properties at acidic pH are thus common to all H. pylori strains, whereas mucin binding at neutral pH occurs via the bacterial BabA adhesin and the Leb antigen/related structures on the glycoprotein. Our work shows that microbe binding to membrane-bound mucins must be considered in H. pylori colonization, and the potential of these glycoproteins to participate in signalling events implies that microbe binding to such structures may initiate signal transduction over the epithelial layer. Competition between microbe binding to membrane-bound and secreted mucins is therefore an important aspect of host–microbe interaction." @default.
• W2070640326 created "2016-06-24" @default.
• W2070640326 creator A5017472767 @default.
• W2070640326 creator A5057607733 @default.
• W2070640326 creator A5073651728 @default.
• W2070640326 creator A5080946104 @default.
• W2070640326 creator A5088608717 @default.
• W2070640326 date "2004-11-23" @default.
• W2070640326 modified "2023-10-02" @default.
• W2070640326 title "Effects of pH on <i>Helicobacter pylori</i> binding to human gastric mucins: identification of binding to non-MUC5AC mucins" @default.
• W2070640326 cites W1558134787 @default.
• W2070640326 cites W1989084057 @default.
• W2070640326 cites W2010665830 @default.
• W2070640326 cites W2030336958 @default.
• W2070640326 cites W2047440121 @default.
• W2070640326 cites W2052541899 @default.
• W2070640326 cites W2081400514 @default.
• W2070640326 cites W2081743213 @default.
• W2070640326 cites W2083267921 @default.
• W2070640326 cites W2089803113 @default.
• W2070640326 cites W2109678144 @default.
• W2070640326 cites W2110132014 @default.
• W2070640326 cites W2114798556 @default.
• W2070640326 cites W2115852459 @default.
• W2070640326 cites W2117879926 @default.
• W2070640326 cites W2121080125 @default.
• W2070640326 cites W2130691519 @default.
• W2070640326 cites W2132932170 @default.
• W2070640326 cites W2138811887 @default.
• W2070640326 cites W2164406413 @default.
• W2070640326 cites W4211017205 @default.
• W2070640326 cites W4236936223 @default.
• W2070640326 doi "https://doi.org/10.1042/bj20040402" @default.
• W2070640326 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1134109" @default.
• W2070640326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15260802" @default.
• W2070640326 hasPublicationYear "2004" @default.
• W2070640326 type Work @default.
• W2070640326 sameAs 2070640326 @default.
• W2070640326 citedByCount "92" @default.
• W2070640326 countsByYear W20706403262012 @default.
• W2070640326 countsByYear W20706403262013 @default.
• W2070640326 countsByYear W20706403262014 @default.
• W2070640326 countsByYear W20706403262015 @default.
• W2070640326 countsByYear W20706403262016 @default.
• W2070640326 countsByYear W20706403262017 @default.
• W2070640326 countsByYear W20706403262018 @default.
• W2070640326 countsByYear W20706403262019 @default.
• W2070640326 countsByYear W20706403262020 @default.
• W2070640326 countsByYear W20706403262021 @default.
• W2070640326 countsByYear W20706403262022 @default.
• W2070640326 countsByYear W20706403262023 @default.
• W2070640326 crossrefType "journal-article" @default.
• W2070640326 hasAuthorship W2070640326A5017472767 @default.
• W2070640326 hasAuthorship W2070640326A5057607733 @default.
• W2070640326 hasAuthorship W2070640326A5073651728 @default.
• W2070640326 hasAuthorship W2070640326A5080946104 @default.
• W2070640326 hasAuthorship W2070640326A5088608717 @default.
• W2070640326 hasBestOaLocation W20706403262 @default.
• W2070640326 hasConcept C104317684 @default.
• W2070640326 hasConcept C107824862 @default.
• W2070640326 hasConcept C108625454 @default.
• W2070640326 hasConcept C179264091 @default.
• W2070640326 hasConcept C179470777 @default.
• W2070640326 hasConcept C185592680 @default.
• W2070640326 hasConcept C2776409635 @default.
• W2070640326 hasConcept C49039625 @default.
• W2070640326 hasConcept C54355233 @default.
• W2070640326 hasConcept C547475151 @default.
• W2070640326 hasConcept C55493867 @default.
• W2070640326 hasConcept C86803240 @default.
• W2070640326 hasConcept C89423630 @default.
• W2070640326 hasConceptScore W2070640326C104317684 @default.
• W2070640326 hasConceptScore W2070640326C107824862 @default.
• W2070640326 hasConceptScore W2070640326C108625454 @default.
• W2070640326 hasConceptScore W2070640326C179264091 @default.
• W2070640326 hasConceptScore W2070640326C179470777 @default.
• W2070640326 hasConceptScore W2070640326C185592680 @default.
• W2070640326 hasConceptScore W2070640326C2776409635 @default.
• W2070640326 hasConceptScore W2070640326C49039625 @default.
• W2070640326 hasConceptScore W2070640326C54355233 @default.
• W2070640326 hasConceptScore W2070640326C547475151 @default.
• W2070640326 hasConceptScore W2070640326C55493867 @default.
• W2070640326 hasConceptScore W2070640326C86803240 @default.
• W2070640326 hasConceptScore W2070640326C89423630 @default.
• W2070640326 hasIssue "2" @default.
• W2070640326 hasLocation W20706403261 @default.
• W2070640326 hasLocation W20706403262 @default.
• W2070640326 hasLocation W20706403263 @default.
• W2070640326 hasLocation W20706403264 @default.
• W2070640326 hasOpenAccess W2070640326 @default.
• W2070640326 hasPrimaryLocation W20706403261 @default.
• W2070640326 hasRelatedWork W1967009692 @default.
• W2070640326 hasRelatedWork W2027779579 @default.
• W2070640326 hasRelatedWork W2145557715 @default.
• W2070640326 hasRelatedWork W2362350295 @default.
• W2070640326 hasRelatedWork W2412360684 @default.
• W2070640326 hasRelatedWork W2467837949 @default.
• W2070640326 hasRelatedWork W2724302880 @default.

• next