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• W2070648660 endingPage "e55316" @default.
• W2070648660 startingPage "e55316" @default.
• W2070648660 abstract "Neuroblastoma is an aggressive childhood disease of the sympathetic nervous system. Treatments are often ineffective and have serious side effects. Conventional therapy of neuroblastoma includes the differentiation agents. Unlike chemo-radiotherapy, differentiation therapy shows minimal side effects on normal cells, because normal non-malignant cells are already differentiated. Keeping in view the limited toxicity of Withania somnifera (Ashwagandha), the current study was aimed to investigate the efficacy of Ashwagandha water extract (ASH-WEX) for anti-proliferative potential in neuroblastoma and its underlying signalling mechanisms. ASH-WEX significantly reduced cell proliferation and induced cell differentiation as indicated by morphological changes and NF200 expression in human IMR-32 neuroblastoma cells. The induction of differentiation was accompanied by HSP70 and mortalin induction as well as pancytoplasmic translocation of the mortalin in ASH-WEX treated cells. Furthermore, the ASH-WEX treatment lead to induction of neural cell adhesion molecule (NCAM) expression and reduction in its polysialylation, thus elucidating its anti-migratory potential, which was also supported by downregulation of MMP 2 and 9 activity. ASH-WEX treatment led to cell cycle arrest at G0/G1 phase and increase in early apoptotic population. Modulation of cell cycle marker Cyclin D1, anti-apoptotic marker bcl-xl and Akt-P provide evidence that ASH-WEX may prove to be a promising phytotherapeutic intervention in neuroblatoma related malignancies." @default.
• W2070648660 created "2016-06-24" @default.
• W2070648660 creator A5015993199 @default.
• W2070648660 creator A5037043745 @default.
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• W2070648660 creator A5059888683 @default.
• W2070648660 date "2013-01-31" @default.
• W2070648660 modified "2023-09-27" @default.
• W2070648660 title "Withania somnifera Water Extract as a Potential Candidate for Differentiation Based Therapy of Human Neuroblastomas" @default.
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• W2070648660 doi "https://doi.org/10.1371/journal.pone.0055316" @default.
• W2070648660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3561198" @default.
• W2070648660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23383150" @default.
• W2070648660 hasPublicationYear "2013" @default.
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