Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070653865> ?p ?o ?g. }
- W2070653865 endingPage "e1001860" @default.
- W2070653865 startingPage "e1001860" @default.
- W2070653865 abstract "During biogenesis of the 40S and 60S ribosomal subunits, the pre-40S particles are exported to the cytoplasm prior to final cleavage of the 20S pre-rRNA to mature 18S rRNA. Amongst the factors involved in this maturation step, Fap7 is unusual, as it both interacts with ribosomal protein Rps14 and harbors adenylate kinase activity, a function not usually associated with ribonucleoprotein assembly. Human hFap7 also regulates Cajal body assembly and cell cycle progression via the p53–MDM2 pathway. This work presents the functional and structural characterization of the Fap7–Rps14 complex. We report that Fap7 association blocks the RNA binding surface of Rps14 and, conversely, Rps14 binding inhibits adenylate kinase activity of Fap7. In addition, the affinity of Fap7 for Rps14 is higher with bound ADP, whereas ATP hydrolysis dissociates the complex. These results suggest that Fap7 chaperones Rps14 assembly into pre-40S particles via RNA mimicry in an ATP-dependent manner. Incorporation of Rps14 by Fap7 leads to a structural rearrangement of the platform domain necessary for the pre-rRNA to acquire a cleavage competent conformation." @default.
- W2070653865 created "2016-06-24" @default.
- W2070653865 creator A5004357736 @default.
- W2070653865 creator A5019312718 @default.
- W2070653865 creator A5022410186 @default.
- W2070653865 creator A5035754718 @default.
- W2070653865 creator A5035866135 @default.
- W2070653865 creator A5036266649 @default.
- W2070653865 creator A5037517011 @default.
- W2070653865 creator A5044128684 @default.
- W2070653865 creator A5058278172 @default.
- W2070653865 creator A5061549098 @default.
- W2070653865 creator A5070466550 @default.
- W2070653865 creator A5084909568 @default.
- W2070653865 creator A5088382820 @default.
- W2070653865 creator A5090689277 @default.
- W2070653865 date "2014-05-13" @default.
- W2070653865 modified "2023-10-18" @default.
- W2070653865 title "RNA Mimicry by the Fap7 Adenylate Kinase in Ribosome Biogenesis" @default.
- W2070653865 cites W1968127704 @default.
- W2070653865 cites W1976051941 @default.
- W2070653865 cites W1980473722 @default.
- W2070653865 cites W1982126789 @default.
- W2070653865 cites W1983105869 @default.
- W2070653865 cites W1985629904 @default.
- W2070653865 cites W1992191979 @default.
- W2070653865 cites W1995277701 @default.
- W2070653865 cites W1996959647 @default.
- W2070653865 cites W1998314279 @default.
- W2070653865 cites W2005112443 @default.
- W2070653865 cites W2005981503 @default.
- W2070653865 cites W2011953977 @default.
- W2070653865 cites W2013051407 @default.
- W2070653865 cites W2014225713 @default.
- W2070653865 cites W2016136365 @default.
- W2070653865 cites W2016410352 @default.
- W2070653865 cites W2029425828 @default.
- W2070653865 cites W2031017387 @default.
- W2070653865 cites W2032145133 @default.
- W2070653865 cites W2032838868 @default.
- W2070653865 cites W2036817582 @default.
- W2070653865 cites W2042688172 @default.
- W2070653865 cites W2050091361 @default.
- W2070653865 cites W2050656609 @default.
- W2070653865 cites W2053218712 @default.
- W2070653865 cites W2054142963 @default.
- W2070653865 cites W2055497972 @default.
- W2070653865 cites W2060167034 @default.
- W2070653865 cites W2063084749 @default.
- W2070653865 cites W2065283382 @default.
- W2070653865 cites W2066088601 @default.
- W2070653865 cites W2073142322 @default.
- W2070653865 cites W2075268529 @default.
- W2070653865 cites W2078419867 @default.
- W2070653865 cites W2085529732 @default.
- W2070653865 cites W2087555780 @default.
- W2070653865 cites W2089249881 @default.
- W2070653865 cites W2108921801 @default.
- W2070653865 cites W2110312673 @default.
- W2070653865 cites W2118183757 @default.
- W2070653865 cites W2119670312 @default.
- W2070653865 cites W2121533623 @default.
- W2070653865 cites W2124983865 @default.
- W2070653865 cites W2125269117 @default.
- W2070653865 cites W2126139416 @default.
- W2070653865 cites W2126707827 @default.
- W2070653865 cites W2126974066 @default.
- W2070653865 cites W2139137642 @default.
- W2070653865 cites W2142412083 @default.
- W2070653865 cites W2144362290 @default.
- W2070653865 cites W2150994390 @default.
- W2070653865 cites W2153410912 @default.
- W2070653865 cites W2154303981 @default.
- W2070653865 cites W2156235751 @default.
- W2070653865 cites W2156854872 @default.
- W2070653865 cites W2158471243 @default.
- W2070653865 cites W2160615487 @default.
- W2070653865 cites W2163341755 @default.
- W2070653865 cites W2164361934 @default.
- W2070653865 cites W2166025848 @default.
- W2070653865 cites W2167734189 @default.
- W2070653865 cites W2171398693 @default.
- W2070653865 cites W2180229411 @default.
- W2070653865 cites W2916336743 @default.
- W2070653865 doi "https://doi.org/10.1371/journal.pbio.1001860" @default.
- W2070653865 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4019466" @default.
- W2070653865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24823650" @default.
- W2070653865 hasPublicationYear "2014" @default.
- W2070653865 type Work @default.
- W2070653865 sameAs 2070653865 @default.
- W2070653865 citedByCount "39" @default.
- W2070653865 countsByYear W20706538652014 @default.
- W2070653865 countsByYear W20706538652015 @default.
- W2070653865 countsByYear W20706538652016 @default.
- W2070653865 countsByYear W20706538652017 @default.
- W2070653865 countsByYear W20706538652018 @default.
- W2070653865 countsByYear W20706538652019 @default.
- W2070653865 countsByYear W20706538652020 @default.