FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070667065> ?p ?o ?g. }

• W2070667065 endingPage "283" @default.
• W2070667065 startingPage "273" @default.
• W2070667065 abstract "Extremely small doses of TCDD have been shown to induce hepatic microsomal enzymes in animals. Whether levels of environmental exposure to TCDD were sufficient to produce enzyme induction in man, has been investigated in Seveso, where in July 1976 an explosion in a factory spread toxic substances, one of which was TCDD, to the surrounding area. The hepatic microsomal enzyme activity was assessed by estimating urinary d-glucaric acid (UGA) excretion in children 6–8 years old. In 31 children, urine samples were collected between August and December 1976; in 67 other children in February 1979. As a control group 60 children living in Busto Arsizio (a small industrial town near Milan) and 26 living in Cannero (a non-industrialized village on Lake Maggiore) were chosen. In the first period of collection, children with chloracne (which is considered to be a characteristic manifestation of intoxication with chlorinated products), showed significantly increased levels of UGA compared with children without chloracne. In 1979, children living in the Seveso area showed a statistically significant enhancement of d-glucaric acid excretion compared to the control groups. In conclusion, this study demonstrates that many children living in the Seveso area have an increased activity of hepatic microsomal enzymes, since, although the urinary excretion of d-glucaric acid is only an indirect measure of enzyme activity, studies in man have indicated that it is both sensitive and quantitative. As far as the cause of this increase is concerned, since it is possible to exclude the influence of alcohol, contraceptives, phenobarbitone or other drugs, it is reasonable to conclude that TCDD, a potent inducer agent, could be responsible for this phenomenon." @default.
• W2070667065 created "2016-06-24" @default.
• W2070667065 creator A5003028936 @default.
• W2070667065 creator A5004477454 @default.
• W2070667065 creator A5015116266 @default.
• W2070667065 creator A5040299077 @default.
• W2070667065 creator A5060499653 @default.
• W2070667065 creator A5064520148 @default.
• W2070667065 date "1982-04-01" @default.
• W2070667065 modified "2023-10-15" @default.
• W2070667065 title "Increased urinary D-glucaric acid excretion by children living in an area polluted with tetrachlorodibenzoparadioxin (TCDD)" @default.
• W2070667065 cites W1909254787 @default.
• W2070667065 cites W1964700417 @default.
• W2070667065 cites W1964934845 @default.
• W2070667065 cites W1966511144 @default.
• W2070667065 cites W1966690913 @default.
• W2070667065 cites W1969466328 @default.
• W2070667065 cites W1970342003 @default.
• W2070667065 cites W1970587768 @default.
• W2070667065 cites W1972651551 @default.
• W2070667065 cites W1973738653 @default.
• W2070667065 cites W1975038884 @default.
• W2070667065 cites W1977410732 @default.
• W2070667065 cites W1987081292 @default.
• W2070667065 cites W1996188642 @default.
• W2070667065 cites W2000915268 @default.
• W2070667065 cites W2002947252 @default.
• W2070667065 cites W2011844402 @default.
• W2070667065 cites W2020470814 @default.
• W2070667065 cites W2020840975 @default.
• W2070667065 cites W2036514919 @default.
• W2070667065 cites W2045193378 @default.
• W2070667065 cites W2045898773 @default.
• W2070667065 cites W2080345024 @default.
• W2070667065 cites W2235410578 @default.
• W2070667065 cites W2415202919 @default.
• W2070667065 cites W2430318738 @default.
• W2070667065 cites W4230371842 @default.
• W2070667065 cites W4249460886 @default.
• W2070667065 cites W2168986800 @default.
• W2070667065 doi "https://doi.org/10.1016/0009-8981(82)90368-0" @default.
• W2070667065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7074964" @default.
• W2070667065 hasPublicationYear "1982" @default.
• W2070667065 type Work @default.
• W2070667065 sameAs 2070667065 @default.
• W2070667065 citedByCount "37" @default.
• W2070667065 countsByYear W20706670652018 @default.
• W2070667065 crossrefType "journal-article" @default.
• W2070667065 hasAuthorship W2070667065A5003028936 @default.
• W2070667065 hasAuthorship W2070667065A5004477454 @default.
• W2070667065 hasAuthorship W2070667065A5015116266 @default.
• W2070667065 hasAuthorship W2070667065A5040299077 @default.
• W2070667065 hasAuthorship W2070667065A5060499653 @default.
• W2070667065 hasAuthorship W2070667065A5064520148 @default.
• W2070667065 hasConcept C10146269 @default.
• W2070667065 hasConcept C126322002 @default.
• W2070667065 hasConcept C134018914 @default.
• W2070667065 hasConcept C181199279 @default.
• W2070667065 hasConcept C185592680 @default.
• W2070667065 hasConcept C2780026642 @default.
• W2070667065 hasConcept C28212737 @default.
• W2070667065 hasConcept C3020359197 @default.
• W2070667065 hasConcept C33070731 @default.
• W2070667065 hasConcept C42407357 @default.
• W2070667065 hasConcept C55493867 @default.
• W2070667065 hasConcept C71924100 @default.
• W2070667065 hasConcept C77411442 @default.
• W2070667065 hasConcept C86803240 @default.
• W2070667065 hasConcept C87644729 @default.
• W2070667065 hasConceptScore W2070667065C10146269 @default.
• W2070667065 hasConceptScore W2070667065C126322002 @default.
• W2070667065 hasConceptScore W2070667065C134018914 @default.
• W2070667065 hasConceptScore W2070667065C181199279 @default.
• W2070667065 hasConceptScore W2070667065C185592680 @default.
• W2070667065 hasConceptScore W2070667065C2780026642 @default.
• W2070667065 hasConceptScore W2070667065C28212737 @default.
• W2070667065 hasConceptScore W2070667065C3020359197 @default.
• W2070667065 hasConceptScore W2070667065C33070731 @default.
• W2070667065 hasConceptScore W2070667065C42407357 @default.
• W2070667065 hasConceptScore W2070667065C55493867 @default.
• W2070667065 hasConceptScore W2070667065C71924100 @default.
• W2070667065 hasConceptScore W2070667065C77411442 @default.
• W2070667065 hasConceptScore W2070667065C86803240 @default.
• W2070667065 hasConceptScore W2070667065C87644729 @default.
• W2070667065 hasIssue "3" @default.
• W2070667065 hasLocation W20706670651 @default.
• W2070667065 hasLocation W20706670652 @default.
• W2070667065 hasOpenAccess W2070667065 @default.
• W2070667065 hasPrimaryLocation W20706670651 @default.
• W2070667065 hasRelatedWork W1973091272 @default.
• W2070667065 hasRelatedWork W2003094270 @default.
• W2070667065 hasRelatedWork W2032847918 @default.
• W2070667065 hasRelatedWork W2059373368 @default.
• W2070667065 hasRelatedWork W2061639816 @default.
• W2070667065 hasRelatedWork W2069992064 @default.
• W2070667065 hasRelatedWork W2093166709 @default.
• W2070667065 hasRelatedWork W2416062844 @default.
• W2070667065 hasRelatedWork W2748952813 @default.

• next