FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070690122> ?p ?o ?g. }

• W2070690122 abstract "1. Effects of protein kinase C (PKC) activators and inhibitors on both tritium overflow and subsequent contraction evoked by transmural nerve stimulation (TNS) were investigated in canine saphenous veins prelabelled with [3H]-noradrenaline. 2. Activation of PKC by stepwise increasing concentrations (0.01 nM-1 microM) of 12-O-tetradecanoylphorbol 13-acetate (TPA), phorbol 12,13-dibutyrate (PDBu) or mezerein caused a significant and concentration-dependent enhancement of the tritium overflow evoked by TNS, while the activators failed to affect the corresponding contraction except with the highest concentration of PDBu when the contraction was significantly reduced. Phorbol, which is inactive on PKC, had no effects on the tritium overflow and contraction induced by TNS. 3. PKC inhibitors, polymyxin B (1 and 10 microM) and the isoquinolinesulphonamide, H-7 (1 microM), inhibited significantly the phorbol ester-potentiated tritium overflow evoked by TNS with no effects on the contraction. H-7 and the related inhibitor H-8 at 10 microM reduced significantly both responses to TNS in the presence of TPA, while they suppressed only the TNS-induced contraction in the absence of TPA. 4. None of the PKC activators or inhibitors affected the spontaneous tritium overflow. 5. PDBu (0.01 and 0.1 microM) elevated resting tension of the veins more effectively than TPA and mezerein. 6. These results suggest that PKC may modulate electrically stimulated noradrenaline release from adrenergic nerve endings of the canine saphenous veins and the PKC activators may act more selectively on presynaptic than postsynaptic sites, but have no apparent effect on postjunctional noradrenergic mechanisms." @default.
• W2070690122 created "2016-06-24" @default.
• W2070690122 creator A5005376447 @default.
• W2070690122 creator A5038813552 @default.
• W2070690122 creator A5086723545 @default.
• W2070690122 date "1991-04-01" @default.
• W2070690122 modified "2023-09-26" @default.
• W2070690122 title "A selective effect of protein kinase C activators on noradrenaline release compared with subsequent contraction in canine isolated saphenous veins" @default.
• W2070690122 cites W110355901 @default.
• W2070690122 cites W1486602990 @default.
• W2070690122 cites W1594758412 @default.
• W2070690122 cites W1964839077 @default.
• W2070690122 cites W1969275677 @default.
• W2070690122 cites W1970521537 @default.
• W2070690122 cites W1973454785 @default.
• W2070690122 cites W1975403531 @default.
• W2070690122 cites W1982083105 @default.
• W2070690122 cites W1990758248 @default.
• W2070690122 cites W1995642360 @default.
• W2070690122 cites W1997612327 @default.
• W2070690122 cites W1997915801 @default.
• W2070690122 cites W1997956038 @default.
• W2070690122 cites W1998438368 @default.
• W2070690122 cites W1998609823 @default.
• W2070690122 cites W2001692359 @default.
• W2070690122 cites W2003296584 @default.
• W2070690122 cites W2008893167 @default.
• W2070690122 cites W2011292527 @default.
• W2070690122 cites W2013100512 @default.
• W2070690122 cites W2019673520 @default.
• W2070690122 cites W2020968617 @default.
• W2070690122 cites W2026034676 @default.
• W2070690122 cites W2043445106 @default.
• W2070690122 cites W2044546864 @default.
• W2070690122 cites W2056570185 @default.
• W2070690122 cites W2076690965 @default.
• W2070690122 cites W2086543154 @default.
• W2070690122 cites W2087524116 @default.
• W2070690122 cites W2095582986 @default.
• W2070690122 cites W2100419209 @default.
• W2070690122 cites W2131534293 @default.
• W2070690122 cites W2266009509 @default.
• W2070690122 cites W2413756831 @default.
• W2070690122 cites W2416194043 @default.
• W2070690122 cites W2419492731 @default.
• W2070690122 cites W2424325901 @default.
• W2070690122 doi "https://doi.org/10.1111/j.1476-5381.1991.tb12283.x" @default.
• W2070690122 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1917975" @default.
• W2070690122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1855124" @default.
• W2070690122 hasPublicationYear "1991" @default.
• W2070690122 type Work @default.
• W2070690122 sameAs 2070690122 @default.
• W2070690122 citedByCount "6" @default.
• W2070690122 countsByYear W20706901222013 @default.
• W2070690122 crossrefType "journal-article" @default.
• W2070690122 hasAuthorship W2070690122A5005376447 @default.
• W2070690122 hasAuthorship W2070690122A5038813552 @default.
• W2070690122 hasAuthorship W2070690122A5086723545 @default.
• W2070690122 hasBestOaLocation W20706901222 @default.
• W2070690122 hasConcept C126322002 @default.
• W2070690122 hasConcept C134018914 @default.
• W2070690122 hasConcept C163415756 @default.
• W2070690122 hasConcept C184235292 @default.
• W2070690122 hasConcept C185592680 @default.
• W2070690122 hasConcept C195794163 @default.
• W2070690122 hasConcept C24998067 @default.
• W2070690122 hasConcept C2776050358 @default.
• W2070690122 hasConcept C2780043322 @default.
• W2070690122 hasConcept C2909761558 @default.
• W2070690122 hasConcept C55493867 @default.
• W2070690122 hasConcept C71924100 @default.
• W2070690122 hasConcept C86803240 @default.
• W2070690122 hasConceptScore W2070690122C126322002 @default.
• W2070690122 hasConceptScore W2070690122C134018914 @default.
• W2070690122 hasConceptScore W2070690122C163415756 @default.
• W2070690122 hasConceptScore W2070690122C184235292 @default.
• W2070690122 hasConceptScore W2070690122C185592680 @default.
• W2070690122 hasConceptScore W2070690122C195794163 @default.
• W2070690122 hasConceptScore W2070690122C24998067 @default.
• W2070690122 hasConceptScore W2070690122C2776050358 @default.
• W2070690122 hasConceptScore W2070690122C2780043322 @default.
• W2070690122 hasConceptScore W2070690122C2909761558 @default.
• W2070690122 hasConceptScore W2070690122C55493867 @default.
• W2070690122 hasConceptScore W2070690122C71924100 @default.
• W2070690122 hasConceptScore W2070690122C86803240 @default.
• W2070690122 hasLocation W20706901221 @default.
• W2070690122 hasLocation W20706901222 @default.
• W2070690122 hasLocation W20706901223 @default.
• W2070690122 hasLocation W20706901224 @default.
• W2070690122 hasOpenAccess W2070690122 @default.
• W2070690122 hasPrimaryLocation W20706901221 @default.
• W2070690122 hasRelatedWork W1956062754 @default.
• W2070690122 hasRelatedWork W1982017809 @default.
• W2070690122 hasRelatedWork W2011584433 @default.
• W2070690122 hasRelatedWork W2025162880 @default.
• W2070690122 hasRelatedWork W2040646620 @default.
• W2070690122 hasRelatedWork W2065224155 @default.
• W2070690122 hasRelatedWork W2083666507 @default.
• W2070690122 hasRelatedWork W2100264247 @default.
• W2070690122 hasRelatedWork W2102581783 @default.

• next