FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070693578> ?p ?o ?g. }

• W2070693578 endingPage "43" @default.
• W2070693578 startingPage "39" @default.
• W2070693578 abstract "A major impediment in the treatment of neurological diseases is the presence of the blood–brain barrier, which precludes the entry of therapeutic molecules from blood to brain. Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA) to the brain. This 29-amino-acid peptide specifically binds to the acetylcholine receptor expressed by neuronal cells. To enable siRNA binding, a chimaeric peptide was synthesized by adding nonamer arginine residues at the carboxy terminus of RVG. This RVG-9R peptide was able to bind and transduce siRNA to neuronal cells in vitro, resulting in efficient gene silencing. After intravenous injection into mice, RVG-9R delivered siRNA to the neuronal cells, resulting in specific gene silencing within the brain. Furthermore, intravenous treatment with RVG-9R-bound antiviral siRNA afforded robust protection against fatal viral encephalitis in mice. Repeated administration of RVG-9R-bound siRNA did not induce inflammatory cytokines or anti-peptide antibodies. Thus, RVG-9R provides a safe and noninvasive approach for the delivery of siRNA and potentially other therapeutic molecules across the blood–brain barrier. Since the discovery of gene silencing by naturally occurring small interfering RNA (siRNA) molecules, the idea that they might be used therapeutically has been up and running. Several reports of systemic delivery of siRNAs have been published, but the brain was not among the targets, because of that old problem, the blood–brain barrier. Now a collaboration between labs in the United States and South Korea has developed a way of delivering siRNAs across the barrier. The method, which is suitable for other types of drug as well as siRNA, makes use of a short peptide derived from the rabies virus as a transporter for the RNA. As well as delivering the RNA into neuronal cells in cell culture, an antiviral siRNA was delivered specifically into the brains of mice infected with encephalitis: about 80% of the mice survived the normally fatal infection. If replicated in humans, this work could lead to the development of noninvasive intravenous treatments for neurological disorders. Attachment of a piece of viral protein to a small RNA achieves transfer of the RNA into neuronal cells in cell culture. This was also able to deliver an antiviral siRNA specifically into the brains of mice infected with encephalitis and achieve 80% protection. This study opens a new potential line of treatment for neuronal disease." @default.
• W2070693578 created "2016-06-24" @default.
• W2070693578 creator A5007213796 @default.
• W2070693578 creator A5031120884 @default.
• W2070693578 creator A5035268320 @default.
• W2070693578 creator A5044981665 @default.
• W2070693578 creator A5056799105 @default.
• W2070693578 creator A5076034595 @default.
• W2070693578 creator A5076586650 @default.
• W2070693578 creator A5076718909 @default.
• W2070693578 creator A5077047943 @default.
• W2070693578 date "2007-06-17" @default.
• W2070693578 modified "2023-10-14" @default.
• W2070693578 title "Transvascular delivery of small interfering RNA to the central nervous system" @default.
• W2070693578 cites W1585640564 @default.
• W2070693578 cites W1973895646 @default.
• W2070693578 cites W1978227190 @default.
• W2070693578 cites W1981312603 @default.
• W2070693578 cites W1982076909 @default.
• W2070693578 cites W1987455162 @default.
• W2070693578 cites W1993391799 @default.
• W2070693578 cites W2001493784 @default.
• W2070693578 cites W2003339498 @default.
• W2070693578 cites W2015511149 @default.
• W2070693578 cites W2019631541 @default.
• W2070693578 cites W2029766213 @default.
• W2070693578 cites W2029827106 @default.
• W2070693578 cites W2041372573 @default.
• W2070693578 cites W2047165821 @default.
• W2070693578 cites W2047836608 @default.
• W2070693578 cites W2090888546 @default.
• W2070693578 cites W2095048886 @default.
• W2070693578 cites W2095151181 @default.
• W2070693578 cites W2101722758 @default.
• W2070693578 cites W2116424844 @default.
• W2070693578 cites W2117401390 @default.
• W2070693578 cites W2121035803 @default.
• W2070693578 cites W2123650819 @default.
• W2070693578 cites W2125057438 @default.
• W2070693578 cites W2139053364 @default.
• W2070693578 cites W2141335195 @default.
• W2070693578 cites W2145159785 @default.
• W2070693578 cites W2151191049 @default.
• W2070693578 cites W2163791529 @default.
• W2070693578 cites W2168339179 @default.
• W2070693578 cites W2170725202 @default.
• W2070693578 cites W3022371810 @default.
• W2070693578 doi "https://doi.org/10.1038/nature05901" @default.
• W2070693578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17572664" @default.
• W2070693578 hasPublicationYear "2007" @default.
• W2070693578 type Work @default.
• W2070693578 sameAs 2070693578 @default.
• W2070693578 citedByCount "1069" @default.
• W2070693578 countsByYear W20706935782012 @default.
• W2070693578 countsByYear W20706935782013 @default.
• W2070693578 countsByYear W20706935782014 @default.
• W2070693578 countsByYear W20706935782015 @default.
• W2070693578 countsByYear W20706935782016 @default.
• W2070693578 countsByYear W20706935782017 @default.
• W2070693578 countsByYear W20706935782018 @default.
• W2070693578 countsByYear W20706935782019 @default.
• W2070693578 countsByYear W20706935782020 @default.
• W2070693578 countsByYear W20706935782021 @default.
• W2070693578 countsByYear W20706935782022 @default.
• W2070693578 countsByYear W20706935782023 @default.
• W2070693578 crossrefType "journal-article" @default.
• W2070693578 hasAuthorship W2070693578A5007213796 @default.
• W2070693578 hasAuthorship W2070693578A5031120884 @default.
• W2070693578 hasAuthorship W2070693578A5035268320 @default.
• W2070693578 hasAuthorship W2070693578A5044981665 @default.
• W2070693578 hasAuthorship W2070693578A5056799105 @default.
• W2070693578 hasAuthorship W2070693578A5076034595 @default.
• W2070693578 hasAuthorship W2070693578A5076586650 @default.
• W2070693578 hasAuthorship W2070693578A5076718909 @default.
• W2070693578 hasAuthorship W2070693578A5077047943 @default.
• W2070693578 hasBestOaLocation W20706935781 @default.
• W2070693578 hasConcept C104317684 @default.
• W2070693578 hasConcept C119056186 @default.
• W2070693578 hasConcept C166703698 @default.
• W2070693578 hasConcept C169760540 @default.
• W2070693578 hasConcept C185592680 @default.
• W2070693578 hasConcept C202751555 @default.
• W2070693578 hasConcept C22615655 @default.
• W2070693578 hasConcept C2778402981 @default.
• W2070693578 hasConcept C2779281246 @default.
• W2070693578 hasConcept C529278444 @default.
• W2070693578 hasConcept C55493867 @default.
• W2070693578 hasConcept C67705224 @default.
• W2070693578 hasConcept C71924100 @default.
• W2070693578 hasConcept C86803240 @default.
• W2070693578 hasConcept C95444343 @default.
• W2070693578 hasConceptScore W2070693578C104317684 @default.
• W2070693578 hasConceptScore W2070693578C119056186 @default.
• W2070693578 hasConceptScore W2070693578C166703698 @default.
• W2070693578 hasConceptScore W2070693578C169760540 @default.
• W2070693578 hasConceptScore W2070693578C185592680 @default.
• W2070693578 hasConceptScore W2070693578C202751555 @default.
• W2070693578 hasConceptScore W2070693578C22615655 @default.

• next