FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070698839> ?p ?o ?g. }

• W2070698839 endingPage "257" @default.
• W2070698839 startingPage "247" @default.
• W2070698839 abstract "Middle cerebral artery occlusion (MCAO) in rats is a well-studied experimental model for ischemic stroke leading to brain infarction and functional deficits. Many preclinical studies have focused on a small time window after the ischemic episode to evaluate functional outcome for screening therapeutic candidates. Short evaluation periods following injury have led to significant setbacks due to lack of information on the delayed effects of treatments, as well as short-lived and reversible neuroprotection, so called false-positive results. In this report, we evaluated long-term functional deficit for 90 days after MCAO in two rat strains with two durations of ischemic insult, in order to identify the best experimental paradigm to assess injury and subsequent recovery. Behavioral outcomes were measured pre-MCAO followed by weekly assessment post-stroke. Behavioral tests included the 18-point composite neurological score, 28-point neuroscore, rearing test, vibrissae-evoked forelimb placing test, foot fault test and the CatWalk. Brain lesions were assessed to correlate injury to behavior outcomes at the end of study. Our results indicate that infarction volume in Sprague-Dawley rats was dependent on occlusion duration. In contrast, the infarction volume in Wistar rats did not correlate with the duration of ischemic episode. Functional outcomes were not dependent on occlusion time in either strain; however, measurable deficits were detectable long-term in limb asymmetry, 18- and 28-point neuroscores, forelimb placing, paw swing speed, and gait coordination. In conclusion, these behavioral assays, in combination with an extended long-term assessment period, can be used for evaluating therapeutic candidates in preclinical models of ischemic stroke." @default.
• W2070698839 created "2016-06-24" @default.
• W2070698839 creator A5008886657 @default.
• W2070698839 creator A5063633399 @default.
• W2070698839 creator A5067216256 @default.
• W2070698839 creator A5072569216 @default.
• W2070698839 creator A5079652069 @default.
• W2070698839 creator A5089825582 @default.
• W2070698839 date "2011-03-01" @default.
• W2070698839 modified "2023-10-17" @default.
• W2070698839 title "Long-term behavioral assessment of function in an experimental model for ischemic stroke" @default.
• W2070698839 cites W1974135000 @default.
• W2070698839 cites W1979109520 @default.
• W2070698839 cites W1983640224 @default.
• W2070698839 cites W1984971671 @default.
• W2070698839 cites W2007498774 @default.
• W2070698839 cites W2013900800 @default.
• W2070698839 cites W2031955562 @default.
• W2070698839 cites W2038636807 @default.
• W2070698839 cites W2043886102 @default.
• W2070698839 cites W2053196806 @default.
• W2070698839 cites W2063679775 @default.
• W2070698839 cites W2067080154 @default.
• W2070698839 cites W2068108590 @default.
• W2070698839 cites W2068423530 @default.
• W2070698839 cites W2076953388 @default.
• W2070698839 cites W2081554944 @default.
• W2070698839 cites W2084388307 @default.
• W2070698839 cites W2085113673 @default.
• W2070698839 cites W2086167759 @default.
• W2070698839 cites W2090816339 @default.
• W2070698839 cites W2104967914 @default.
• W2070698839 cites W2121146828 @default.
• W2070698839 cites W2125683177 @default.
• W2070698839 cites W2131618976 @default.
• W2070698839 cites W2134845552 @default.
• W2070698839 cites W2139233239 @default.
• W2070698839 cites W2150842829 @default.
• W2070698839 cites W2161103092 @default.
• W2070698839 doi "https://doi.org/10.1016/j.jneumeth.2011.01.010" @default.
• W2070698839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3539723" @default.
• W2070698839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21256866" @default.
• W2070698839 hasPublicationYear "2011" @default.
• W2070698839 type Work @default.
• W2070698839 sameAs 2070698839 @default.
• W2070698839 citedByCount "112" @default.
• W2070698839 countsByYear W20706988392012 @default.
• W2070698839 countsByYear W20706988392013 @default.
• W2070698839 countsByYear W20706988392014 @default.
• W2070698839 countsByYear W20706988392015 @default.
• W2070698839 countsByYear W20706988392016 @default.
• W2070698839 countsByYear W20706988392017 @default.
• W2070698839 countsByYear W20706988392018 @default.
• W2070698839 countsByYear W20706988392019 @default.
• W2070698839 countsByYear W20706988392020 @default.
• W2070698839 countsByYear W20706988392021 @default.
• W2070698839 countsByYear W20706988392022 @default.
• W2070698839 countsByYear W20706988392023 @default.
• W2070698839 crossrefType "journal-article" @default.
• W2070698839 hasAuthorship W2070698839A5008886657 @default.
• W2070698839 hasAuthorship W2070698839A5063633399 @default.
• W2070698839 hasAuthorship W2070698839A5067216256 @default.
• W2070698839 hasAuthorship W2070698839A5072569216 @default.
• W2070698839 hasAuthorship W2070698839A5079652069 @default.
• W2070698839 hasAuthorship W2070698839A5089825582 @default.
• W2070698839 hasBestOaLocation W20706988392 @default.
• W2070698839 hasConcept C105702510 @default.
• W2070698839 hasConcept C126322002 @default.
• W2070698839 hasConcept C127413603 @default.
• W2070698839 hasConcept C15744967 @default.
• W2070698839 hasConcept C164705383 @default.
• W2070698839 hasConcept C169760540 @default.
• W2070698839 hasConcept C25498285 @default.
• W2070698839 hasConcept C2777798775 @default.
• W2070698839 hasConcept C2778646069 @default.
• W2070698839 hasConcept C2780645631 @default.
• W2070698839 hasConcept C42219234 @default.
• W2070698839 hasConcept C500558357 @default.
• W2070698839 hasConcept C541997718 @default.
• W2070698839 hasConcept C71924100 @default.
• W2070698839 hasConcept C78519656 @default.
• W2070698839 hasConcept C99508421 @default.
• W2070698839 hasConceptScore W2070698839C105702510 @default.
• W2070698839 hasConceptScore W2070698839C126322002 @default.
• W2070698839 hasConceptScore W2070698839C127413603 @default.
• W2070698839 hasConceptScore W2070698839C15744967 @default.
• W2070698839 hasConceptScore W2070698839C164705383 @default.
• W2070698839 hasConceptScore W2070698839C169760540 @default.
• W2070698839 hasConceptScore W2070698839C25498285 @default.
• W2070698839 hasConceptScore W2070698839C2777798775 @default.
• W2070698839 hasConceptScore W2070698839C2778646069 @default.
• W2070698839 hasConceptScore W2070698839C2780645631 @default.
• W2070698839 hasConceptScore W2070698839C42219234 @default.
• W2070698839 hasConceptScore W2070698839C500558357 @default.
• W2070698839 hasConceptScore W2070698839C541997718 @default.
• W2070698839 hasConceptScore W2070698839C71924100 @default.
• W2070698839 hasConceptScore W2070698839C78519656 @default.
• W2070698839 hasConceptScore W2070698839C99508421 @default.

• next