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• W2070701400 abstract "The genetic attributes of the influenza virus lead to unique problems in vaccination. First, a highly mutable RNA genome, resulting in sequential antigenic variation, could potentially manifest as a vaccine failure or epidemic influenza. Second, a segmented genome that engenders the virus with the capacity for genetic reassortment and the introduction of new antigens into a host population could possibly result in a pandemic. The core problem in combating influenza is the need for continual vaccine revision and induction of broader heterovariant immunity. Current vaccines – the conventional inactivated vaccine and the live attenuated vaccine – rely on technology of strain selection and production methods that is decades old. The immunity induced by these vaccines is dominated by the response to hemagglutinin (HA) and, therefore, the vaccines are most effective when there is sufficient antigenic relatedness between the vaccine strain HA and the circulating wild-type virus HA. Consequently, these vaccines are susceptible to failure when an antigenically distinct virus emerges after the selection of the vaccine candidate strain. New vaccine strategies need to include immunization with other viral antigens in addition to HA, thereby broadening the immune response against influenza. Inclusion of the more slowly evolving neuraminidase and/or M2e in a vaccine against influenza could reduce the vulnerability to antigenic changes, and conserved antigens from internal proteins – nucleoprotein and M1 – delivered to induce T-cell helper and cytotoxic T cells, could ensure the presence of activated T cells that facilitate clearance of pandemic strains. Alternative production technologies, such as recombinant baculovirus and yeast, and different delivery methods, such as virus-like particles, should be explored to decrease vaccine production times and reduce reliance on embryonated eggs." @default.
• W2070701400 created "2016-06-24" @default.
• W2070701400 creator A5001799635 @default.
• W2070701400 creator A5020025180 @default.
• W2070701400 date "2010-09-01" @default.
• W2070701400 modified "2023-09-26" @default.
• W2070701400 title "Influenza: a unique problem in vaccination" @default.
• W2070701400 cites W1483301458 @default.
• W2070701400 cites W1487328217 @default.
• W2070701400 cites W1596441602 @default.
• W2070701400 cites W1655902188 @default.
• W2070701400 cites W1820541549 @default.
• W2070701400 cites W1897992263 @default.
• W2070701400 cites W1916389848 @default.
• W2070701400 cites W1965031326 @default.
• W2070701400 cites W1965449675 @default.
• W2070701400 cites W1965529336 @default.
• W2070701400 cites W1966893415 @default.
• W2070701400 cites W1967136629 @default.
• W2070701400 cites W1968395412 @default.
• W2070701400 cites W1969544615 @default.
• W2070701400 cites W1978790143 @default.
• W2070701400 cites W1979158913 @default.
• W2070701400 cites W1983574379 @default.
• W2070701400 cites W1984221593 @default.
• W2070701400 cites W1986051946 @default.
• W2070701400 cites W1993666065 @default.
• W2070701400 cites W2001752071 @default.
• W2070701400 cites W2002429449 @default.
• W2070701400 cites W2012979946 @default.
• W2070701400 cites W2013686628 @default.
• W2070701400 cites W2015210358 @default.
• W2070701400 cites W2016572212 @default.
• W2070701400 cites W2017309788 @default.
• W2070701400 cites W2017630852 @default.
• W2070701400 cites W2017795981 @default.
• W2070701400 cites W2018424830 @default.
• W2070701400 cites W2024557230 @default.
• W2070701400 cites W2025333144 @default.
• W2070701400 cites W2028189879 @default.
• W2070701400 cites W2029566681 @default.
• W2070701400 cites W2029691277 @default.
• W2070701400 cites W2032916431 @default.
• W2070701400 cites W2039817228 @default.
• W2070701400 cites W2041942201 @default.
• W2070701400 cites W2042611040 @default.
• W2070701400 cites W2045934762 @default.
• W2070701400 cites W2046926288 @default.
• W2070701400 cites W2048375908 @default.
• W2070701400 cites W2049342216 @default.
• W2070701400 cites W2049985206 @default.
• W2070701400 cites W2050306038 @default.
• W2070701400 cites W2051459836 @default.
• W2070701400 cites W2052139590 @default.
• W2070701400 cites W2059646132 @default.
• W2070701400 cites W2066699285 @default.
• W2070701400 cites W2067727963 @default.
• W2070701400 cites W2070426326 @default.
• W2070701400 cites W2071366247 @default.
• W2070701400 cites W2077963581 @default.
• W2070701400 cites W2082873732 @default.
• W2070701400 cites W2083963178 @default.
• W2070701400 cites W2084465880 @default.
• W2070701400 cites W2087142631 @default.
• W2070701400 cites W2088401612 @default.
• W2070701400 cites W2088517066 @default.
• W2070701400 cites W2091080683 @default.
• W2070701400 cites W2093172488 @default.
• W2070701400 cites W2098137295 @default.
• W2070701400 cites W2098832466 @default.
• W2070701400 cites W2101954404 @default.
• W2070701400 cites W2102750406 @default.
• W2070701400 cites W2102847984 @default.
• W2070701400 cites W2103093438 @default.
• W2070701400 cites W2107587363 @default.
• W2070701400 cites W2107598742 @default.
• W2070701400 cites W2113352022 @default.
• W2070701400 cites W2115037143 @default.
• W2070701400 cites W2116061999 @default.
• W2070701400 cites W2124212192 @default.
• W2070701400 cites W2124920694 @default.
• W2070701400 cites W2127035967 @default.
• W2070701400 cites W2127840828 @default.
• W2070701400 cites W2131129654 @default.
• W2070701400 cites W2131155575 @default.
• W2070701400 cites W2131170401 @default.
• W2070701400 cites W2131945847 @default.
• W2070701400 cites W2132710964 @default.
• W2070701400 cites W2137378887 @default.
• W2070701400 cites W2137681090 @default.
• W2070701400 cites W2144155542 @default.
• W2070701400 cites W2150172575 @default.
• W2070701400 cites W2152163546 @default.
• W2070701400 cites W2158286218 @default.
• W2070701400 cites W2166572749 @default.
• W2070701400 cites W2167360046 @default.
• W2070701400 cites W2170731906 @default.
• W2070701400 cites W2314489476 @default.

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