FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070702585> ?p ?o ?g. }

• W2070702585 endingPage "1884" @default.
• W2070702585 startingPage "1873" @default.
• W2070702585 abstract "The SBM mouse is a unique transgenic model of polycystic kidney disease (PKD) induced by the dysregulated expression of c-myc in renal tissue. In situ hybridization analysis demonstrated intense signal for the c-myc transgene overlying tubular cystic epithelium in SBM mice. Renal proliferation index in SBM kidneys was 10-fold increased over nontransgenic controls correlating with the presence of epithelial hyperplasia. The specificity of c-myc for the proliferative potential of epithelial cells was demonstrated by substitution of c-myc with the proto-oncogene c-fos or the transforming growth factor (TGF)-α within the same construct. No renal abnormalities were detected in 13 transgenic lines established, indicating that the PKD phenotype is dependent on functions specific to c-myc. We also investigated another well characterized function of c-myc, the regulation of apoptosis through pathways involving p53 and members of the bcl-2 family, which induce and inhibit apoptosis, respectively. The SBM kidney tissues, which overexpress c-myc, displayed a markedly elevated (10–100-fold) apoptotic index. However, no significant difference in bcl-2, bax, or p53 expression was observed in SBM kidney compared with controls. Direct proof that the heightened renal cellular apoptosis in PKD is not occurring through p53 was obtained by successive matings between SBM and p53−/− mice. All SBM offspring, irrespective of their p53 genotype, developed PKD with increased renal epithelial apoptotic index. In addition, overexpression of both bcl-2 and c-myc in double transgenic mice (SBB+/SBM+) also produced a similar PKD phenotype with a high apoptotic rate, showing that c-myc can bypass bcl-2 in vivo. Thus, the in vivo c-myc apoptotic pathway in SBM mice occurs through a p53- and bcl-2–independent mechanism. We conclude that the pathogenesis of PKD is c-myc specific and involves a critical imbalance between the opposing processes of cell proliferation and apoptosis." @default.
• W2070702585 created "2016-06-24" @default.
• W2070702585 creator A5004877715 @default.
• W2070702585 creator A5019594246 @default.
• W2070702585 creator A5021094151 @default.
• W2070702585 creator A5021097392 @default.
• W2070702585 creator A5045521332 @default.
• W2070702585 creator A5073621219 @default.
• W2070702585 creator A5080996526 @default.
• W2070702585 date "1997-12-01" @default.
• W2070702585 modified "2023-10-12" @default.
• W2070702585 title "C-MYC–induced Apoptosis in Polycystic Kidney Disease Is Bcl-2 and p53 Independent" @default.
• W2070702585 cites W1498586399 @default.
• W2070702585 cites W1515473967 @default.
• W2070702585 cites W1639877697 @default.
• W2070702585 cites W1966683022 @default.
• W2070702585 cites W1968075576 @default.
• W2070702585 cites W1975489321 @default.
• W2070702585 cites W1977187249 @default.
• W2070702585 cites W1980561309 @default.
• W2070702585 cites W1982882974 @default.
• W2070702585 cites W1992093075 @default.
• W2070702585 cites W1994283705 @default.
• W2070702585 cites W1994830470 @default.
• W2070702585 cites W1995430086 @default.
• W2070702585 cites W2008597649 @default.
• W2070702585 cites W2009603041 @default.
• W2070702585 cites W2012602645 @default.
• W2070702585 cites W2013330927 @default.
• W2070702585 cites W2015622740 @default.
• W2070702585 cites W2016499189 @default.
• W2070702585 cites W2045086385 @default.
• W2070702585 cites W2058591356 @default.
• W2070702585 cites W2059627145 @default.
• W2070702585 cites W2068606395 @default.
• W2070702585 cites W2068889468 @default.
• W2070702585 cites W2088406835 @default.
• W2070702585 cites W2093628776 @default.
• W2070702585 cites W2094555201 @default.
• W2070702585 cites W2104072661 @default.
• W2070702585 cites W2104328711 @default.
• W2070702585 cites W2119615058 @default.
• W2070702585 cites W2126679757 @default.
• W2070702585 cites W2132110877 @default.
• W2070702585 cites W2132963869 @default.
• W2070702585 cites W2134979684 @default.
• W2070702585 cites W2163307259 @default.
• W2070702585 cites W2188389684 @default.
• W2070702585 cites W2260309202 @default.
• W2070702585 cites W2289751621 @default.
• W2070702585 cites W2339651665 @default.
• W2070702585 cites W2400667787 @default.
• W2070702585 cites W2407713516 @default.
• W2070702585 cites W4290348899 @default.
• W2070702585 cites W48044147 @default.
• W2070702585 doi "https://doi.org/10.1084/jem.186.11.1873" @default.
• W2070702585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2199149" @default.
• W2070702585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9382886" @default.
• W2070702585 hasPublicationYear "1997" @default.
• W2070702585 type Work @default.
• W2070702585 sameAs 2070702585 @default.
• W2070702585 citedByCount "87" @default.
• W2070702585 countsByYear W20707025852012 @default.
• W2070702585 countsByYear W20707025852013 @default.
• W2070702585 countsByYear W20707025852014 @default.
• W2070702585 countsByYear W20707025852015 @default.
• W2070702585 countsByYear W20707025852016 @default.
• W2070702585 countsByYear W20707025852017 @default.
• W2070702585 countsByYear W20707025852018 @default.
• W2070702585 countsByYear W20707025852019 @default.
• W2070702585 countsByYear W20707025852020 @default.
• W2070702585 countsByYear W20707025852021 @default.
• W2070702585 countsByYear W20707025852023 @default.
• W2070702585 crossrefType "journal-article" @default.
• W2070702585 hasAuthorship W2070702585A5004877715 @default.
• W2070702585 hasAuthorship W2070702585A5019594246 @default.
• W2070702585 hasAuthorship W2070702585A5021094151 @default.
• W2070702585 hasAuthorship W2070702585A5021097392 @default.
• W2070702585 hasAuthorship W2070702585A5045521332 @default.
• W2070702585 hasAuthorship W2070702585A5073621219 @default.
• W2070702585 hasAuthorship W2070702585A5080996526 @default.
• W2070702585 hasBestOaLocation W20707025851 @default.
• W2070702585 hasConcept C102230213 @default.
• W2070702585 hasConcept C104317684 @default.
• W2070702585 hasConcept C126322002 @default.
• W2070702585 hasConcept C134018914 @default.
• W2070702585 hasConcept C141035611 @default.
• W2070702585 hasConcept C150194340 @default.
• W2070702585 hasConcept C153911025 @default.
• W2070702585 hasConcept C190283241 @default.
• W2070702585 hasConcept C2777562237 @default.
• W2070702585 hasConcept C2780091579 @default.
• W2070702585 hasConcept C2780145431 @default.
• W2070702585 hasConcept C2781018059 @default.
• W2070702585 hasConcept C29537977 @default.
• W2070702585 hasConcept C502942594 @default.
• W2070702585 hasConcept C55493867 @default.
• W2070702585 hasConcept C71924100 @default.

• next