Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070707989> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2070707989 abstract "5-Azacytidine (5AzC), a cytidine analogue, is thought to induce apoptosis in fetal neuronal cells and PC12 cells through DNA hypomethylation. However, apoptosis can be inhibited by adding protein synthesis inhibitors, indicating de novo protein synthesis may be partially responsible for apoptosis. Therefore, genes expressed just before apoptosis from 5AzC-treated PC12 cells were cloned. cDNA libraries were prepared from both 5AzC-treated and untreated PC12 cells and these libraries were subtracted. One clone overexpressed in 5AzC-treated PC12 cells was obtained, and was identified as the nearly full length (9 nt at 5' end and 1 nt at 3' end missing) rat ribosomal protein L4 (rpL4) gene. Time course study of Northern blot analysis in 5AzC-treated PC12 cells revealed that the peak of rat rpL4 gene expression preceded DNA fragmentation. COS-7 cells transfected with different amounts of cDNA from the subtracted clone expressed rat rpL4 dose-dependently. DNA fragmentation in the transfected COS-7 cells occurred proportional to the amount of the cDNA used for transfection. The present study indicates that rat rpL4 gene expression selectively increases in PC12 cells prior to 5AzC-induced apoptosis and that COS-7 cells transfected with and expressing the rat rpL4 gene also undergo apoptosis." @default.
- W2070707989 created "2016-06-24" @default.
- W2070707989 creator A5006695063 @default.
- W2070707989 creator A5018714183 @default.
- W2070707989 creator A5035447685 @default.
- W2070707989 creator A5067326029 @default.
- W2070707989 creator A5080550833 @default.
- W2070707989 creator A5082886918 @default.
- W2070707989 creator A5085408037 @default.
- W2070707989 creator A5086535576 @default.
- W2070707989 date "1998-11-01" @default.
- W2070707989 modified "2023-10-03" @default.
- W2070707989 title "Increased Expression of Rat Ribosomal Protein L4 mRNA in 5-Azacytidine-Treated PC12 Cells Prior to Apoptosis" @default.
- W2070707989 cites W1935442240 @default.
- W2070707989 cites W1976687669 @default.
- W2070707989 cites W1986386760 @default.
- W2070707989 cites W1992288855 @default.
- W2070707989 cites W1994220877 @default.
- W2070707989 cites W2030023390 @default.
- W2070707989 cites W2033764083 @default.
- W2070707989 cites W2051001991 @default.
- W2070707989 cites W2066022960 @default.
- W2070707989 cites W2066321210 @default.
- W2070707989 cites W2072181069 @default.
- W2070707989 cites W2084118479 @default.
- W2070707989 cites W2108237850 @default.
- W2070707989 cites W2129754994 @default.
- W2070707989 cites W2145750252 @default.
- W2070707989 cites W2149252348 @default.
- W2070707989 cites W2151172630 @default.
- W2070707989 cites W2410734627 @default.
- W2070707989 cites W1999166276 @default.
- W2070707989 doi "https://doi.org/10.1006/bbrc.1998.9633" @default.
- W2070707989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9813173" @default.
- W2070707989 hasPublicationYear "1998" @default.
- W2070707989 type Work @default.
- W2070707989 sameAs 2070707989 @default.
- W2070707989 citedByCount "10" @default.
- W2070707989 countsByYear W20707079892013 @default.
- W2070707989 crossrefType "journal-article" @default.
- W2070707989 hasAuthorship W2070707989A5006695063 @default.
- W2070707989 hasAuthorship W2070707989A5018714183 @default.
- W2070707989 hasAuthorship W2070707989A5035447685 @default.
- W2070707989 hasAuthorship W2070707989A5067326029 @default.
- W2070707989 hasAuthorship W2070707989A5080550833 @default.
- W2070707989 hasAuthorship W2070707989A5082886918 @default.
- W2070707989 hasAuthorship W2070707989A5085408037 @default.
- W2070707989 hasAuthorship W2070707989A5086535576 @default.
- W2070707989 hasConcept C104317684 @default.
- W2070707989 hasConcept C105580179 @default.
- W2070707989 hasConcept C150194340 @default.
- W2070707989 hasConcept C153911025 @default.
- W2070707989 hasConcept C177707886 @default.
- W2070707989 hasConcept C187882448 @default.
- W2070707989 hasConcept C190283241 @default.
- W2070707989 hasConcept C31573885 @default.
- W2070707989 hasConcept C43759708 @default.
- W2070707989 hasConcept C54009773 @default.
- W2070707989 hasConcept C54355233 @default.
- W2070707989 hasConcept C55493867 @default.
- W2070707989 hasConcept C81885089 @default.
- W2070707989 hasConcept C86803240 @default.
- W2070707989 hasConceptScore W2070707989C104317684 @default.
- W2070707989 hasConceptScore W2070707989C105580179 @default.
- W2070707989 hasConceptScore W2070707989C150194340 @default.
- W2070707989 hasConceptScore W2070707989C153911025 @default.
- W2070707989 hasConceptScore W2070707989C177707886 @default.
- W2070707989 hasConceptScore W2070707989C187882448 @default.
- W2070707989 hasConceptScore W2070707989C190283241 @default.
- W2070707989 hasConceptScore W2070707989C31573885 @default.
- W2070707989 hasConceptScore W2070707989C43759708 @default.
- W2070707989 hasConceptScore W2070707989C54009773 @default.
- W2070707989 hasConceptScore W2070707989C54355233 @default.
- W2070707989 hasConceptScore W2070707989C55493867 @default.
- W2070707989 hasConceptScore W2070707989C81885089 @default.
- W2070707989 hasConceptScore W2070707989C86803240 @default.
- W2070707989 hasLocation W20707079891 @default.
- W2070707989 hasLocation W20707079892 @default.
- W2070707989 hasOpenAccess W2070707989 @default.
- W2070707989 hasPrimaryLocation W20707079891 @default.
- W2070707989 hasRelatedWork W1984019227 @default.
- W2070707989 hasRelatedWork W1991955639 @default.
- W2070707989 hasRelatedWork W2004348186 @default.
- W2070707989 hasRelatedWork W2030540411 @default.
- W2070707989 hasRelatedWork W2126448511 @default.
- W2070707989 hasRelatedWork W2142848209 @default.
- W2070707989 hasRelatedWork W2326751717 @default.
- W2070707989 hasRelatedWork W2350324307 @default.
- W2070707989 hasRelatedWork W2364319975 @default.
- W2070707989 hasRelatedWork W2386072750 @default.
- W2070707989 isParatext "false" @default.
- W2070707989 isRetracted "false" @default.
- W2070707989 magId "2070707989" @default.
- W2070707989 workType "article" @default.