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• W2070719090 abstract "We have used Surface Plasmon Resonance (SPR) – based biosensor technology to investigate the interaction of the six high affinity insulin-like growth factor binding proteins (IGFBP 1–6) with the cell binding domain (CBD) of fibronectin. Using a biotinylated derivative of the ninth and tenth TypeIII domains of FN (9–10FNIII), we show that IGFBP-3 and -5 bind to FN-CBD. We show that this binding is inhibited by IGF-I and that, for IGFBP-5, binding occurs through the C-terminal heparin binding domain of the protein. Using site-directed mutagenesis of 9–10FNIII, we show both the “synergy” and RGD sites within these FN domains are required for maximum binding of both IGFBPs. We discuss the possible biological consequences of our results." @default.
• W2070719090 created "2016-06-24" @default.
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• W2070719090 date "2009-04-01" @default.
• W2070719090 modified "2023-10-16" @default.
• W2070719090 title "IGFBP-3 and IGFBP-5 associate with the cell binding domain (CBD) of fibronectin" @default.
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• W2070719090 doi "https://doi.org/10.1016/j.bbrc.2009.02.088" @default.
• W2070719090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19236847" @default.
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