FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070730931> ?p ?o ?g. }

• W2070730931 endingPage "e24077" @default.
• W2070730931 startingPage "e24077" @default.
• W2070730931 abstract "MUC1 protein is an attractive target for anticancer drug delivery owing to its overexpression in most adenocarcinomas. In this study, a reported MUC1 protein aptamer is exploited as the targeting agent of a nanoparticle-based drug delivery system. Paclitaxel (PTX) loaded poly (lactic-co-glycolic-acid) (PLGA) nanoparticles were formulated by an emulsion/evaporation method, and MUC1 aptamers (Apt) were conjugated to the particle surface through a DNA spacer. The aptamer conjugated nanoparticles (Apt-NPs) are about 225.3 nm in size with a stable in vitro drug release profile. Using MCF-7 breast cancer cell as a MUC1-overexpressing model, the MUC1 aptamer increased the uptake of nanoparticles into the target cells as measured by flow cytometry. Moreover, the PTX loaded Apt-NPs enhanced in vitro drug delivery and cytotoxicity to MUC1(+) cancer cells, as compared with non-targeted nanoparticles that lack the MUC1 aptamer (P<0.01). The behavior of this novel aptamer-nanoparticle bioconjugates suggests that MUC1 aptamers may have application potential in targeted drug delivery towards MUC1-overexpressing tumors." @default.
• W2070730931 created "2016-06-24" @default.
• W2070730931 creator A5012931311 @default.
• W2070730931 creator A5013038112 @default.
• W2070730931 creator A5013656851 @default.
• W2070730931 creator A5037787906 @default.
• W2070730931 creator A5047138797 @default.
• W2070730931 creator A5055344461 @default.
• W2070730931 creator A5079942435 @default.
• W2070730931 date "2011-09-01" @default.
• W2070730931 modified "2023-10-11" @default.
• W2070730931 title "Novel Aptamer-Nanoparticle Bioconjugates Enhances Delivery of Anticancer Drug to MUC1-Positive Cancer Cells In Vitro" @default.
• W2070730931 cites W1560482245 @default.
• W2070730931 cites W1971733758 @default.
• W2070730931 cites W1981989535 @default.
• W2070730931 cites W1995980440 @default.
• W2070730931 cites W1997465664 @default.
• W2070730931 cites W2019555018 @default.
• W2070730931 cites W2027104228 @default.
• W2070730931 cites W2028656900 @default.
• W2070730931 cites W2028893730 @default.
• W2070730931 cites W2046802601 @default.
• W2070730931 cites W2046851174 @default.
• W2070730931 cites W2058369946 @default.
• W2070730931 cites W2061113020 @default.
• W2070730931 cites W2072750787 @default.
• W2070730931 cites W2073066818 @default.
• W2070730931 cites W2083982805 @default.
• W2070730931 cites W2097535374 @default.
• W2070730931 cites W2097950450 @default.
• W2070730931 cites W2106249361 @default.
• W2070730931 cites W2116511587 @default.
• W2070730931 cites W2126500509 @default.
• W2070730931 cites W2126901672 @default.
• W2070730931 cites W2127865078 @default.
• W2070730931 cites W2129360146 @default.
• W2070730931 cites W2135883962 @default.
• W2070730931 cites W2165732324 @default.
• W2070730931 cites W2171632125 @default.
• W2070730931 doi "https://doi.org/10.1371/journal.pone.0024077" @default.
• W2070730931 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3164674" @default.
• W2070730931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21912664" @default.
• W2070730931 hasPublicationYear "2011" @default.
• W2070730931 type Work @default.
• W2070730931 sameAs 2070730931 @default.
• W2070730931 citedByCount "145" @default.
• W2070730931 countsByYear W20707309312012 @default.
• W2070730931 countsByYear W20707309312013 @default.
• W2070730931 countsByYear W20707309312014 @default.
• W2070730931 countsByYear W20707309312015 @default.
• W2070730931 countsByYear W20707309312016 @default.
• W2070730931 countsByYear W20707309312017 @default.
• W2070730931 countsByYear W20707309312018 @default.
• W2070730931 countsByYear W20707309312019 @default.
• W2070730931 countsByYear W20707309312020 @default.
• W2070730931 countsByYear W20707309312021 @default.
• W2070730931 countsByYear W20707309312022 @default.
• W2070730931 countsByYear W20707309312023 @default.
• W2070730931 crossrefType "journal-article" @default.
• W2070730931 hasAuthorship W2070730931A5012931311 @default.
• W2070730931 hasAuthorship W2070730931A5013038112 @default.
• W2070730931 hasAuthorship W2070730931A5013656851 @default.
• W2070730931 hasAuthorship W2070730931A5037787906 @default.
• W2070730931 hasAuthorship W2070730931A5047138797 @default.
• W2070730931 hasAuthorship W2070730931A5055344461 @default.
• W2070730931 hasAuthorship W2070730931A5079942435 @default.
• W2070730931 hasBestOaLocation W20707309311 @default.
• W2070730931 hasConcept C109316439 @default.
• W2070730931 hasConcept C112613896 @default.
• W2070730931 hasConcept C121608353 @default.
• W2070730931 hasConcept C12554922 @default.
• W2070730931 hasConcept C126511603 @default.
• W2070730931 hasConcept C128972844 @default.
• W2070730931 hasConcept C153911025 @default.
• W2070730931 hasConcept C171250308 @default.
• W2070730931 hasConcept C178790620 @default.
• W2070730931 hasConcept C179264091 @default.
• W2070730931 hasConcept C185592680 @default.
• W2070730931 hasConcept C192562407 @default.
• W2070730931 hasConcept C202751555 @default.
• W2070730931 hasConcept C2777292972 @default.
• W2070730931 hasConcept C2777421810 @default.
• W2070730931 hasConcept C2779820397 @default.
• W2070730931 hasConcept C2780165375 @default.
• W2070730931 hasConcept C521977710 @default.
• W2070730931 hasConcept C54355233 @default.
• W2070730931 hasConcept C553184892 @default.
• W2070730931 hasConcept C55493867 @default.
• W2070730931 hasConcept C86803240 @default.
• W2070730931 hasConcept C96232424 @default.
• W2070730931 hasConceptScore W2070730931C109316439 @default.
• W2070730931 hasConceptScore W2070730931C112613896 @default.
• W2070730931 hasConceptScore W2070730931C121608353 @default.
• W2070730931 hasConceptScore W2070730931C12554922 @default.
• W2070730931 hasConceptScore W2070730931C126511603 @default.
• W2070730931 hasConceptScore W2070730931C128972844 @default.
• W2070730931 hasConceptScore W2070730931C153911025 @default.
• W2070730931 hasConceptScore W2070730931C171250308 @default.

• next