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- W2070743887 startingPage "960" @default.
- W2070743887 abstract "Angiogenesis is a key component of cancer growth, invasion and metastasis. Therefore, inhibition of angiogenesis is an attractive strategy for the treatment of cancer. We systematically describe phase II and III clinical trials of bevacizumab for the treatment of breast cancer. Methods A computer-based literature search was carried out using PUBMED and conference databases. Original phase II and III studies reporting ⩾15 patients who received bevacizumab were included. Results 41 phase II trials were identified in the metastatic setting. Most trials found bevacizumab treatment feasible. Response rates (RR) varied from 0% to 76.5%, time to progression (TTP)/progression free survival (PFS) from 2.4 to 25.3 months and overall survival from 11.5 to more than 38 months. 14 phase III trials including more than 4400 patients with MBC unanimously showed increased RR and PFS, however, no trials demonstrated an OS benefit. In the neoadjuvant setting 23 phase II and III trials were identified. All studies found increased pCR/tpCR but no benefit in terms of OS could be demonstrated. The only study conducted in the adjuvant setting failed to show any survival benefit of bevacizumab. Conclusion Despite increased response rates in both the metastatic and neoadjuvant setting, bevacizumab has failed to show any OS benefit. Future trials should include identification of robust predictive biomarkers in order to improve our understanding of molecular biomarkers and mechanisms." @default.
- W2070743887 created "2016-06-24" @default.
- W2070743887 creator A5051005093 @default.
- W2070743887 creator A5076834460 @default.
- W2070743887 creator A5090876784 @default.
- W2070743887 date "2014-09-01" @default.
- W2070743887 modified "2023-10-07" @default.
- W2070743887 title "A systematic review of bevacizumab efficacy in breast cancer" @default.
- W2070743887 cites W1539571840 @default.
- W2070743887 cites W1964752664 @default.
- W2070743887 cites W1965053406 @default.
- W2070743887 cites W1967600348 @default.
- W2070743887 cites W1970168920 @default.
- W2070743887 cites W1972328572 @default.
- W2070743887 cites W1974162805 @default.
- W2070743887 cites W1976585485 @default.
- W2070743887 cites W1977983810 @default.
- W2070743887 cites W1978138543 @default.
- W2070743887 cites W1979037494 @default.
- W2070743887 cites W1981065236 @default.
- W2070743887 cites W1984750597 @default.
- W2070743887 cites W1989343097 @default.
- W2070743887 cites W2004791242 @default.
- W2070743887 cites W2020724013 @default.
- W2070743887 cites W2021777913 @default.
- W2070743887 cites W2022075549 @default.
- W2070743887 cites W2026718377 @default.
- W2070743887 cites W2034548257 @default.
- W2070743887 cites W2034693832 @default.
- W2070743887 cites W2037317309 @default.
- W2070743887 cites W2040406100 @default.
- W2070743887 cites W2040975353 @default.
- W2070743887 cites W2047759229 @default.
- W2070743887 cites W2049051984 @default.
- W2070743887 cites W2051135332 @default.
- W2070743887 cites W2060447671 @default.
- W2070743887 cites W2061094294 @default.
- W2070743887 cites W2061467078 @default.
- W2070743887 cites W2075610273 @default.
- W2070743887 cites W2078249980 @default.
- W2070743887 cites W2079898907 @default.
- W2070743887 cites W2085946496 @default.
- W2070743887 cites W2086319302 @default.
- W2070743887 cites W2087071661 @default.
- W2070743887 cites W2091599051 @default.
- W2070743887 cites W2095545927 @default.
- W2070743887 cites W2095704084 @default.
- W2070743887 cites W2096451862 @default.
- W2070743887 cites W2098276344 @default.
- W2070743887 cites W2099818449 @default.
- W2070743887 cites W2099824657 @default.
- W2070743887 cites W2100553911 @default.
- W2070743887 cites W2101485991 @default.
- W2070743887 cites W2103563357 @default.
- W2070743887 cites W2104599448 @default.
- W2070743887 cites W2108273212 @default.
- W2070743887 cites W2109491042 @default.
- W2070743887 cites W2109606826 @default.
- W2070743887 cites W2113361623 @default.
- W2070743887 cites W2114159573 @default.
- W2070743887 cites W2117692326 @default.
- W2070743887 cites W2117835131 @default.
- W2070743887 cites W2118606585 @default.
- W2070743887 cites W2119085065 @default.
- W2070743887 cites W2122298066 @default.
- W2070743887 cites W2122574381 @default.
- W2070743887 cites W2122730895 @default.
- W2070743887 cites W2123592538 @default.
- W2070743887 cites W2125651014 @default.
- W2070743887 cites W2126275851 @default.
- W2070743887 cites W2130771089 @default.
- W2070743887 cites W2131705241 @default.
- W2070743887 cites W2133565170 @default.
- W2070743887 cites W2133764807 @default.
- W2070743887 cites W2135368853 @default.
- W2070743887 cites W2137225981 @default.
- W2070743887 cites W2137721949 @default.
- W2070743887 cites W2139864519 @default.
- W2070743887 cites W2140088548 @default.
- W2070743887 cites W2140376241 @default.
- W2070743887 cites W2143037400 @default.
- W2070743887 cites W2143844247 @default.
- W2070743887 cites W2144159497 @default.
- W2070743887 cites W2144574890 @default.
- W2070743887 cites W2147468938 @default.
- W2070743887 cites W2148536573 @default.
- W2070743887 cites W2152142449 @default.
- W2070743887 cites W2152743592 @default.
- W2070743887 cites W2153026436 @default.
- W2070743887 cites W2153982924 @default.
- W2070743887 cites W2158679766 @default.
- W2070743887 cites W2160875683 @default.
- W2070743887 cites W2163003060 @default.
- W2070743887 cites W2164177263 @default.
- W2070743887 cites W2165906785 @default.
- W2070743887 cites W2166602936 @default.
- W2070743887 cites W2166832443 @default.
- W2070743887 cites W2167224460 @default.