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• W2070750596 abstract "Abstract The benzodiazepines (BZs) are potent antiepileptic agents with diverse biochemical actions. One of their effects is to suppress the catecholamines, which are themselves important inhibitors of seizures. Surprisingly, it was reported that the antiepileptic action of one of the BZs, flurazepam (FZ), for pentylenetetrazol seizures was potentiated after depletion of the catecholamines. This led to the suggestion that the catecholamines interfere with the general antiepileptic action of FZ and other BZs. We examined the antiepileptic action of FZ against a kindled amygdala seizure in four groups: (i) rats depleted of norepinephrine with the neurotoxin 6-hydroxydopamine, ( (ii) rats partially depleted of dopamine, with norepinephrine protected by an injection of desmethylimipramine shortly before administration of the neurotoxin, (iii) a desmethylimipramine control, and (iv) a saline vehicle control. At the highest dose of FZ (20 mg/kg), a substantial antiepileptic effect against the generalized seizure was observed in all groups, whereas only partial suppression of the focal seizure occurred. There were no differences between the four treatment groups. Clearly, with the kindling model of epilepsy, the antiepileptic effect of FZ is not altered by depletion of catecholamines." @default.
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• W2070750596 date "1982-07-01" @default.
• W2070750596 modified "2023-09-27" @default.
• W2070750596 title "Effects of flurazepam on kindled amygdala convulsions in catecholamine-depleted rats" @default.
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• W2070750596 doi "https://doi.org/10.1016/0014-4886(82)90144-3" @default.
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