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- W2070757004 abstract "It has been established that serotonergic pathways project to cerebral areas involved in learning and memory and that serotonin (5-HT) receptor agonists and antagonists modify these processes. Indeed, most of the 5-HT receptors characterized so far, i.e., 5-HT(1) through 5-HT(7), show a regional distribution in brain areas involved in learning and memory, such as hippocampal formation (HF), amygdala and cortex. Although 5-HT(7) receptor biological functions are still to be clarified, it was recently suggested that it may play a role in the control of learning and memory processes. The aim of our study was to assess the role of 5-HT(7) receptors antagonist SB-269970 on working and reference memory in a radial arm maze task, utilizing a two-phase procedure, comprising an acquisition and test phase, conducted to evaluate working and reference memory, respectively. Our results showed that 5-HT(7) receptors antagonist SB-269970 improved memory, decreasing the number of errors in test phase and, thus, affecting reference memory, while no effects were observed in working memory. These results could be explained taking into consideration the specific localization of 5-HT(7) receptors in the CNS. In fact, high concentrations of 5-HT(7) receptors were found in the HF, which exerts an important role on reference memory, while relatively low concentrations were present in the prefrontal cortex, involved in working memory. Thus, 5-HT(7) receptor blockade had procognitive effect, when the learning task implicated a high degree of difficulty. This conclusion has a major implication in the context that 5-HT receptors play an important role under amnesia states (e.g., Alzheimer's disease) or when the learning is complex." @default.
- W2070757004 created "2016-06-24" @default.
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- W2070757004 creator A5023835968 @default.
- W2070757004 creator A5066560802 @default.
- W2070757004 date "2008-12-01" @default.
- W2070757004 modified "2023-10-14" @default.
- W2070757004 title "Effect of 5-HT7 antagonist SB-269970 in the modulation of working and reference memory in the rat" @default.
- W2070757004 cites W12545720 @default.
- W2070757004 cites W1565257873 @default.
- W2070757004 cites W1580869285 @default.
- W2070757004 cites W1973475326 @default.
- W2070757004 cites W1975553009 @default.
- W2070757004 cites W1982288973 @default.
- W2070757004 cites W1987317482 @default.
- W2070757004 cites W1993524896 @default.
- W2070757004 cites W1993681287 @default.
- W2070757004 cites W2002457970 @default.
- W2070757004 cites W2007185003 @default.
- W2070757004 cites W2007785106 @default.
- W2070757004 cites W2008374290 @default.
- W2070757004 cites W2009823120 @default.
- W2070757004 cites W2010221842 @default.
- W2070757004 cites W2012359728 @default.
- W2070757004 cites W2014001501 @default.
- W2070757004 cites W2015615615 @default.
- W2070757004 cites W2017649013 @default.
- W2070757004 cites W2018666202 @default.
- W2070757004 cites W2019900749 @default.
- W2070757004 cites W2020948758 @default.
- W2070757004 cites W2024254226 @default.
- W2070757004 cites W2025887031 @default.
- W2070757004 cites W2028336702 @default.
- W2070757004 cites W2030812260 @default.
- W2070757004 cites W2035953746 @default.
- W2070757004 cites W2036534852 @default.
- W2070757004 cites W2040903359 @default.
- W2070757004 cites W2042535216 @default.
- W2070757004 cites W2044436505 @default.
- W2070757004 cites W2046233213 @default.
- W2070757004 cites W2048868418 @default.
- W2070757004 cites W2048995786 @default.
- W2070757004 cites W2052765108 @default.
- W2070757004 cites W2053720210 @default.
- W2070757004 cites W2056372017 @default.
- W2070757004 cites W2056761692 @default.
- W2070757004 cites W2064669765 @default.
- W2070757004 cites W2067757592 @default.
- W2070757004 cites W2070536623 @default.
- W2070757004 cites W2071468978 @default.
- W2070757004 cites W2074250014 @default.
- W2070757004 cites W2075335330 @default.
- W2070757004 cites W2080308963 @default.
- W2070757004 cites W2080461836 @default.
- W2070757004 cites W2082461271 @default.
- W2070757004 cites W2084193392 @default.
- W2070757004 cites W2085977381 @default.
- W2070757004 cites W2086876322 @default.
- W2070757004 cites W2088183396 @default.
- W2070757004 cites W2089571094 @default.
- W2070757004 cites W2089852647 @default.
- W2070757004 cites W2091064369 @default.
- W2070757004 cites W2093993467 @default.
- W2070757004 cites W2094301775 @default.
- W2070757004 cites W2094391965 @default.
- W2070757004 cites W2094573117 @default.
- W2070757004 cites W2101753940 @default.
- W2070757004 cites W2102438497 @default.
- W2070757004 cites W2103324311 @default.
- W2070757004 cites W2110709054 @default.
- W2070757004 cites W2122403027 @default.
- W2070757004 cites W2124176820 @default.
- W2070757004 cites W2127276359 @default.
- W2070757004 cites W2131553858 @default.
- W2070757004 cites W2133083344 @default.
- W2070757004 cites W2136715578 @default.
- W2070757004 cites W2141742005 @default.
- W2070757004 cites W2143787546 @default.
- W2070757004 cites W2143946826 @default.
- W2070757004 cites W2156544956 @default.
- W2070757004 cites W2157045608 @default.
- W2070757004 cites W2164579326 @default.
- W2070757004 cites W2171264145 @default.
- W2070757004 cites W44850464 @default.
- W2070757004 cites W93191899 @default.
- W2070757004 doi "https://doi.org/10.1016/j.bbr.2007.12.020" @default.
- W2070757004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18308404" @default.
- W2070757004 hasPublicationYear "2008" @default.
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