FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070758048> ?p ?o ?g. }

• W2070758048 endingPage "7501" @default.
• W2070758048 startingPage "7496" @default.
• W2070758048 abstract "HIV-1 entry into cells involves formation of a complex between gp120 of the viral envelope glycoprotein (Env), a receptor (CD4), and a coreceptor. For most strains of HIV, this coreceptor is CCR5. Here, we provide evidence that CD4 is specifically associated with CCR5 in the absence of gp120 or any other receptor-specific ligand. The amount of CD4 coimmunoprecipitated with CCR5 was significantly higher than that with the other major HIV coreceptor, CXCR4, and in contrast to CXCR4 the CD4–CCR5 coimmunoprecipitation was not significantly increased by gp120. The CD4–CCR5 interaction probably takes place via the second extracellular loop of CCR5 and the first two domains of CD4. It can be inhibited by CCR5- and CD4-specific antibodies that interfere with HIV-1 infection, indicating a possible role in virus entry. These findings suggest a possible pathway of HIV-1 evolution and development of immunopathogenicity, a potential new target for antiretroviral drugs and a tool for development of vaccines based on Env–CD4–CCR5 complexes. The constitutive association of a seven-transmembrane-domain G protein-coupled receptor with another receptor also indicates new possibilities for cross-talk between cell surface receptors." @default.
• W2070758048 created "2016-06-24" @default.
• W2070758048 creator A5006321543 @default.
• W2070758048 creator A5023644165 @default.
• W2070758048 creator A5052943622 @default.
• W2070758048 creator A5064530138 @default.
• W2070758048 creator A5064642149 @default.
• W2070758048 creator A5071199689 @default.
• W2070758048 creator A5071765199 @default.
• W2070758048 creator A5086560872 @default.
• W2070758048 creator A5089862290 @default.
• W2070758048 creator A5091567901 @default.
• W2070758048 creator A5059121395 @default.
• W2070758048 date "1999-06-22" @default.
• W2070758048 modified "2023-10-16" @default.
• W2070758048 title "Constitutive cell surface association between CD4 and CCR5" @default.
• W2070758048 cites W1486525240 @default.
• W2070758048 cites W1595120220 @default.
• W2070758048 cites W1617734753 @default.
• W2070758048 cites W1630241876 @default.
• W2070758048 cites W1770879899 @default.
• W2070758048 cites W1790204722 @default.
• W2070758048 cites W1826524642 @default.
• W2070758048 cites W1965019797 @default.
• W2070758048 cites W1966269060 @default.
• W2070758048 cites W1971057735 @default.
• W2070758048 cites W1971777539 @default.
• W2070758048 cites W1972056955 @default.
• W2070758048 cites W1981440980 @default.
• W2070758048 cites W1981644527 @default.
• W2070758048 cites W1989035987 @default.
• W2070758048 cites W1996183144 @default.
• W2070758048 cites W2007243487 @default.
• W2070758048 cites W2017551575 @default.
• W2070758048 cites W2019048081 @default.
• W2070758048 cites W2021917788 @default.
• W2070758048 cites W2028834214 @default.
• W2070758048 cites W2037269543 @default.
• W2070758048 cites W2041906588 @default.
• W2070758048 cites W2051073016 @default.
• W2070758048 cites W2063808707 @default.
• W2070758048 cites W2068803746 @default.
• W2070758048 cites W2075416959 @default.
• W2070758048 cites W2075926278 @default.
• W2070758048 cites W2076082328 @default.
• W2070758048 cites W2089565248 @default.
• W2070758048 cites W2090256415 @default.
• W2070758048 cites W2098781795 @default.
• W2070758048 cites W2112709855 @default.
• W2070758048 cites W2127140898 @default.
• W2070758048 cites W2129875326 @default.
• W2070758048 cites W2131376910 @default.
• W2070758048 cites W2137162710 @default.
• W2070758048 cites W2156117117 @default.
• W2070758048 cites W2162310141 @default.
• W2070758048 cites W2418023117 @default.
• W2070758048 cites W4252035435 @default.
• W2070758048 doi "https://doi.org/10.1073/pnas.96.13.7496" @default.
• W2070758048 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/22114" @default.
• W2070758048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10377443" @default.
• W2070758048 hasPublicationYear "1999" @default.
• W2070758048 type Work @default.
• W2070758048 sameAs 2070758048 @default.
• W2070758048 citedByCount "170" @default.
• W2070758048 countsByYear W20707580482012 @default.
• W2070758048 countsByYear W20707580482013 @default.
• W2070758048 countsByYear W20707580482014 @default.
• W2070758048 countsByYear W20707580482016 @default.
• W2070758048 countsByYear W20707580482017 @default.
• W2070758048 countsByYear W20707580482018 @default.
• W2070758048 countsByYear W20707580482019 @default.
• W2070758048 countsByYear W20707580482020 @default.
• W2070758048 countsByYear W20707580482022 @default.
• W2070758048 crossrefType "journal-article" @default.
• W2070758048 hasAuthorship W2070758048A5006321543 @default.
• W2070758048 hasAuthorship W2070758048A5023644165 @default.
• W2070758048 hasAuthorship W2070758048A5052943622 @default.
• W2070758048 hasAuthorship W2070758048A5059121395 @default.
• W2070758048 hasAuthorship W2070758048A5064530138 @default.
• W2070758048 hasAuthorship W2070758048A5064642149 @default.
• W2070758048 hasAuthorship W2070758048A5071199689 @default.
• W2070758048 hasAuthorship W2070758048A5071765199 @default.
• W2070758048 hasAuthorship W2070758048A5086560872 @default.
• W2070758048 hasAuthorship W2070758048A5089862290 @default.
• W2070758048 hasAuthorship W2070758048A5091567901 @default.
• W2070758048 hasBestOaLocation W20707580482 @default.
• W2070758048 hasConcept C108625454 @default.
• W2070758048 hasConcept C125590012 @default.
• W2070758048 hasConcept C12823836 @default.
• W2070758048 hasConcept C129470790 @default.
• W2070758048 hasConcept C13373296 @default.
• W2070758048 hasConcept C140704245 @default.
• W2070758048 hasConcept C159047783 @default.
• W2070758048 hasConcept C159654299 @default.
• W2070758048 hasConcept C170493617 @default.
• W2070758048 hasConcept C195616568 @default.
• W2070758048 hasConcept C197462201 @default.
• W2070758048 hasConcept C24530287 @default.

• next