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• W2070758851 startingPage "9218" @default.
• W2070758851 abstract "Comparisons of proteins show that they evolve through the movement of domains. However, in many cases, the underlying mechanisms remain unclear. Here, we observed the movements of DNA recognition domains between non-orthologous proteins within a prokaryote genome. Restriction–modification (RM) systems, consisting of a sequence-specific DNA methyltransferase and a restriction enzyme, contribute to maintenance/evolution of genomes/epigenomes. RM systems limit horizontal gene transfer but are themselves mobile. We compared Type III RM systems in Helicobacter pylori genomes and found that target recognition domain (TRD) sequences are mobile, moving between different orthologous groups that occupy unique chromosomal locations. Sequence comparisons suggested that a likely underlying mechanism is movement through homologous recombination of similar DNA sequences that encode amino acid sequence motifs that are conserved among Type III DNA methyltransferases. Consistent with this movement, incongruence was observed between the phylogenetic trees of TRD regions and other regions in proteins. Horizontal acquisition of diverse TRD sequences was suggested by detection of homologs in other Helicobacter species and distantly related bacterial species. One of these RM systems in H. pylori was inactivated by insertion of another RM system that likely transferred from an oral bacterium. TRD movement represents a novel route for diversification of DNA-interacting proteins." @default.
• W2070758851 created "2016-06-24" @default.
• W2070758851 creator A5022775273 @default.
• W2070758851 creator A5047403424 @default.
• W2070758851 date "2012-07-20" @default.
• W2070758851 modified "2023-10-03" @default.
• W2070758851 title "Movement of DNA sequence recognition domains between non-orthologous proteins" @default.
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• W2070758851 doi "https://doi.org/10.1093/nar/gks681" @default.
• W2070758851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3467074" @default.
• W2070758851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22821560" @default.
• W2070758851 hasPublicationYear "2012" @default.
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