FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070764684> ?p ?o ?g. }

• W2070764684 endingPage "614" @default.
• W2070764684 startingPage "610" @default.
• W2070764684 abstract "The epidermal permeability barrier, required for terrestrial life, is localized to lipid-enriched lamellar membranes in the extracellular spaces of the stratum corneum (SC). Immaturity of the SC is a significant contributor to morbidity and mortality in premature infants. Previous studies have shown that supraphysiologic concentrations of thyroid hormone accelerate epidermis/SC ontogenesis. Here we studied SC development in Hyt/Hyt mice who are genetically hypothyroid due to a mutation in the TSH receptor. In control mice on d 18 of gestation (term 19.5 d), only focal areas displayed a mature SC membrane pattern. By 19 d of gestation there was a mature multilayered SC with lamellar unit structures filling the extracellular spaces similar to that seen in mature mice. In Hyt/Hyt mice SC development was delayed at both 18 and 19 d of gestation. In both strains of mice, within the first day after birth there were no differences in epidermal or SC appearance, and the SC was fully mature. These findings indicate that thyroid hormone plays a physiologic role during normal intrauterine development of the SC. However, normal SC maturation ultimately occurs, indicating that thyroid hormone is not absolutely essential. Previous studies have shown that glucocorticoids accelerate SC development in euthyroid rats, and in the present study we demonstrate that glucocorticoids also accelerate SC ontogenesis in euthyroid mice. In contrast, in Hyt/Hyt mice glucocorticoids did not accelerate or normalize SC development, indicating that the glucocorticoid effect on SC maturation requires a euthyroid state or that glucocorticoids act via thyroid hormone. These studies demonstrate that thyroid hormone status is an important regulator of fetal SC development." @default.
• W2070764684 created "2016-06-24" @default.
• W2070764684 creator A5018532799 @default.
• W2070764684 creator A5031984792 @default.
• W2070764684 creator A5040460661 @default.
• W2070764684 creator A5049938896 @default.
• W2070764684 creator A5050608918 @default.
• W2070764684 creator A5051847291 @default.
• W2070764684 creator A5063314679 @default.
• W2070764684 creator A5083628557 @default.
• W2070764684 date "1997-11-01" @default.
• W2070764684 modified "2023-10-11" @default.
• W2070764684 title "Hypothyroidism Delays Fetal Stratum Corneum Development in Mice" @default.
• W2070764684 cites W128536076 @default.
• W2070764684 cites W1525495286 @default.
• W2070764684 cites W1872675327 @default.
• W2070764684 cites W1968654392 @default.
• W2070764684 cites W1978294590 @default.
• W2070764684 cites W1996187835 @default.
• W2070764684 cites W1997023747 @default.
• W2070764684 cites W2002273560 @default.
• W2070764684 cites W2003924950 @default.
• W2070764684 cites W2011642803 @default.
• W2070764684 cites W2014175448 @default.
• W2070764684 cites W2021078471 @default.
• W2070764684 cites W2034819427 @default.
• W2070764684 cites W2035660063 @default.
• W2070764684 cites W2050925937 @default.
• W2070764684 cites W2052909990 @default.
• W2070764684 cites W2053147796 @default.
• W2070764684 cites W2054526929 @default.
• W2070764684 cites W2055201123 @default.
• W2070764684 cites W2059367235 @default.
• W2070764684 cites W2059714246 @default.
• W2070764684 cites W2060771136 @default.
• W2070764684 cites W2067376187 @default.
• W2070764684 cites W2069098706 @default.
• W2070764684 cites W2069837263 @default.
• W2070764684 cites W2070708632 @default.
• W2070764684 cites W2073074765 @default.
• W2070764684 cites W2075092699 @default.
• W2070764684 cites W2094725635 @default.
• W2070764684 cites W2141390960 @default.
• W2070764684 doi "https://doi.org/10.1203/00006450-199711000-00010" @default.
• W2070764684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9357932" @default.
• W2070764684 hasPublicationYear "1997" @default.
• W2070764684 type Work @default.
• W2070764684 sameAs 2070764684 @default.
• W2070764684 citedByCount "32" @default.
• W2070764684 countsByYear W20707646842012 @default.
• W2070764684 countsByYear W20707646842013 @default.
• W2070764684 countsByYear W20707646842014 @default.
• W2070764684 countsByYear W20707646842015 @default.
• W2070764684 countsByYear W20707646842016 @default.
• W2070764684 countsByYear W20707646842018 @default.
• W2070764684 countsByYear W20707646842021 @default.
• W2070764684 crossrefType "journal-article" @default.
• W2070764684 hasAuthorship W2070764684A5018532799 @default.
• W2070764684 hasAuthorship W2070764684A5031984792 @default.
• W2070764684 hasAuthorship W2070764684A5040460661 @default.
• W2070764684 hasAuthorship W2070764684A5049938896 @default.
• W2070764684 hasAuthorship W2070764684A5050608918 @default.
• W2070764684 hasAuthorship W2070764684A5051847291 @default.
• W2070764684 hasAuthorship W2070764684A5063314679 @default.
• W2070764684 hasAuthorship W2070764684A5083628557 @default.
• W2070764684 hasBestOaLocation W20707646841 @default.
• W2070764684 hasConcept C126322002 @default.
• W2070764684 hasConcept C134018914 @default.
• W2070764684 hasConcept C172680121 @default.
• W2070764684 hasConcept C185592680 @default.
• W2070764684 hasConcept C2777195454 @default.
• W2070764684 hasConcept C2778370115 @default.
• W2070764684 hasConcept C2779234561 @default.
• W2070764684 hasConcept C2780841215 @default.
• W2070764684 hasConcept C46973012 @default.
• W2070764684 hasConcept C526584372 @default.
• W2070764684 hasConcept C54355233 @default.
• W2070764684 hasConcept C71315377 @default.
• W2070764684 hasConcept C71924100 @default.
• W2070764684 hasConcept C86803240 @default.
• W2070764684 hasConceptScore W2070764684C126322002 @default.
• W2070764684 hasConceptScore W2070764684C134018914 @default.
• W2070764684 hasConceptScore W2070764684C172680121 @default.
• W2070764684 hasConceptScore W2070764684C185592680 @default.
• W2070764684 hasConceptScore W2070764684C2777195454 @default.
• W2070764684 hasConceptScore W2070764684C2778370115 @default.
• W2070764684 hasConceptScore W2070764684C2779234561 @default.
• W2070764684 hasConceptScore W2070764684C2780841215 @default.
• W2070764684 hasConceptScore W2070764684C46973012 @default.
• W2070764684 hasConceptScore W2070764684C526584372 @default.
• W2070764684 hasConceptScore W2070764684C54355233 @default.
• W2070764684 hasConceptScore W2070764684C71315377 @default.
• W2070764684 hasConceptScore W2070764684C71924100 @default.
• W2070764684 hasConceptScore W2070764684C86803240 @default.
• W2070764684 hasIssue "5" @default.
• W2070764684 hasLocation W20707646841 @default.
• W2070764684 hasLocation W20707646842 @default.
• W2070764684 hasOpenAccess W2070764684 @default.

• next