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- W2070767640 abstract "The magnitude of the Balb/c mouse IgA anti-α(1→3) dextran B1355 (anti-dex) response in vivo was recently found to be markedly T-cell-dependent and age-dependent. This report demonstrates that the in vitro IgA anti-dex response by mesenteric lymph nodes (MLN) is highly age-dependent and that there is an age-dependent increase of the background IgA anti-dex plaque-forming cell (PFC) response occurring in the absence of added antigen which correlates significantly with the magnitude of the antigen-stimulated response. In aging mice both background and antigen-stimulated IgA anti-dex responses appeared to be significantly higher in MLN than in spleen cultures. Moreover, it is shown that there is a striking increase with age of natural antibody in the serum of normal Balb/c to α(1→3) film-in determinants, particularly IgA and lesser amounts of IgM and IgG3." @default.
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- W2070767640 date "1983-02-01" @default.
- W2070767640 modified "2023-09-26" @default.
- W2070767640 title "Age-Dependence of the IgA Anti-alpha(13) Dextran B1355 Response in Vitro" @default.
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- W2070767640 doi "https://doi.org/10.1111/j.1365-3083.1983.tb00773.x" @default.
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