FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070785110> ?p ?o ?g. }

• W2070785110 endingPage "425" @default.
• W2070785110 startingPage "420" @default.
• W2070785110 abstract "There is no question that chronic alcohol (ethanol) abuse, a leading worldwide problem, causes neuronal dysfunction and brain damage. However, various epidemiologic studies in recent years have indicated that in comparisons with abstainers or never-drinkers, light/moderate alcohol consumers have lower risks of age-dependent cognitive decline and/or dementia, including Alzheimer’s disease (AD). Such reduced risks have been variously attributed to favorable circulatory and/or cerebrovascular effects of moderate ethanol intake, but they could also involve ethanol “preconditioning” phenomena in brain glia and neurons. Here we summarize our experimental studies showing that moderate ethanol preconditioning (MEP; 20–30 mM ethanol) of rat brain cultures prevents neurodegeneration due to β-amyloid, an important protein implicated in AD, and to other neuroinflammatory proteins such as gp120, the human immunodeficiency virus 1 envelope protein linked to AIDS dementia. The MEP neuroprotection is associated with suppression of neurotoxic protein-evoked initial increases in [Ca+2]i and proinflammatory mediators—e.g., superoxide anion, arachidonic acid, and glutamate. Applying a sensor → transducer → effector model to MEP, we find that onset of neuroprotection correlates temporally with elevations in “effector” heat shock proteins (HSP70, HSP27, and phospho-HSP27). The effector status of HSPs is supported by the fact that inhibiting HSP elevations due to MEP largely restores gp120-induced superoxide potentiation and subsequent neurotoxicity. As upstream mediators, synaptic N-methyl-d-aspartate receptors may be initial prosurvival sensors of ethanol, and protein kinase C epsilon and focal adhesion kinase are likely transducers during MEP that are essential for protective HSP elevations. Regarding human consumption, we speculate that moderate ethanol intake might counter incipient cognitive deterioration during advanced aging or AD by exerting preconditioning-like suppression of ongoing neuroinflammation related to amyloidogenic protein accumulation." @default.
• W2070785110 created "2016-06-24" @default.
• W2070785110 creator A5002469100 @default.
• W2070785110 creator A5011531318 @default.
• W2070785110 creator A5021439072 @default.
• W2070785110 creator A5036035788 @default.
• W2070785110 creator A5055149017 @default.
• W2070785110 creator A5072764362 @default.
• W2070785110 date "2010-04-28" @default.
• W2070785110 modified "2023-10-05" @default.
• W2070785110 title "Moderate Ethanol Preconditioning of Rat Brain Cultures Engenders Neuroprotection Against Dementia-Inducing Neuroinflammatory Proteins: Possible Signaling Mechanisms" @default.
• W2070785110 cites W1536369380 @default.
• W2070785110 cites W1539503465 @default.
• W2070785110 cites W1965899597 @default.
• W2070785110 cites W1972797480 @default.
• W2070785110 cites W1978423412 @default.
• W2070785110 cites W1980986613 @default.
• W2070785110 cites W1993965498 @default.
• W2070785110 cites W1996383717 @default.
• W2070785110 cites W2006569015 @default.
• W2070785110 cites W2006815009 @default.
• W2070785110 cites W2009812062 @default.
• W2070785110 cites W2009969882 @default.
• W2070785110 cites W2010797209 @default.
• W2070785110 cites W2019464314 @default.
• W2070785110 cites W2038692542 @default.
• W2070785110 cites W2047126558 @default.
• W2070785110 cites W2047244334 @default.
• W2070785110 cites W2047431347 @default.
• W2070785110 cites W2048053028 @default.
• W2070785110 cites W2063175209 @default.
• W2070785110 cites W2068214990 @default.
• W2070785110 cites W2076300347 @default.
• W2070785110 cites W2077346081 @default.
• W2070785110 cites W2080027027 @default.
• W2070785110 cites W2088325006 @default.
• W2070785110 cites W2094741813 @default.
• W2070785110 cites W2095101317 @default.
• W2070785110 cites W2109577620 @default.
• W2070785110 cites W2111348890 @default.
• W2070785110 cites W2125928511 @default.
• W2070785110 cites W2130031072 @default.
• W2070785110 cites W2142885157 @default.
• W2070785110 cites W2165541514 @default.
• W2070785110 cites W3022636911 @default.
• W2070785110 doi "https://doi.org/10.1007/s12035-010-8138-0" @default.
• W2070785110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2908405" @default.
• W2070785110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20422315" @default.
• W2070785110 hasPublicationYear "2010" @default.
• W2070785110 type Work @default.
• W2070785110 sameAs 2070785110 @default.
• W2070785110 citedByCount "45" @default.
• W2070785110 countsByYear W20707851102012 @default.
• W2070785110 countsByYear W20707851102013 @default.
• W2070785110 countsByYear W20707851102014 @default.
• W2070785110 countsByYear W20707851102015 @default.
• W2070785110 countsByYear W20707851102016 @default.
• W2070785110 countsByYear W20707851102018 @default.
• W2070785110 countsByYear W20707851102019 @default.
• W2070785110 countsByYear W20707851102020 @default.
• W2070785110 countsByYear W20707851102022 @default.
• W2070785110 countsByYear W20707851102023 @default.
• W2070785110 crossrefType "journal-article" @default.
• W2070785110 hasAuthorship W2070785110A5002469100 @default.
• W2070785110 hasAuthorship W2070785110A5011531318 @default.
• W2070785110 hasAuthorship W2070785110A5021439072 @default.
• W2070785110 hasAuthorship W2070785110A5036035788 @default.
• W2070785110 hasAuthorship W2070785110A5055149017 @default.
• W2070785110 hasAuthorship W2070785110A5072764362 @default.
• W2070785110 hasBestOaLocation W20707851102 @default.
• W2070785110 hasConcept C104317684 @default.
• W2070785110 hasConcept C126322002 @default.
• W2070785110 hasConcept C169760540 @default.
• W2070785110 hasConcept C170493617 @default.
• W2070785110 hasConcept C203014093 @default.
• W2070785110 hasConcept C205260736 @default.
• W2070785110 hasConcept C25498285 @default.
• W2070785110 hasConcept C2776914184 @default.
• W2070785110 hasConcept C2776925932 @default.
• W2070785110 hasConcept C2779134260 @default.
• W2070785110 hasConcept C2779491297 @default.
• W2070785110 hasConcept C29730261 @default.
• W2070785110 hasConcept C55493867 @default.
• W2070785110 hasConcept C61174792 @default.
• W2070785110 hasConcept C71924100 @default.
• W2070785110 hasConcept C86803240 @default.
• W2070785110 hasConcept C87753298 @default.
• W2070785110 hasConcept C98274493 @default.
• W2070785110 hasConceptScore W2070785110C104317684 @default.
• W2070785110 hasConceptScore W2070785110C126322002 @default.
• W2070785110 hasConceptScore W2070785110C169760540 @default.
• W2070785110 hasConceptScore W2070785110C170493617 @default.
• W2070785110 hasConceptScore W2070785110C203014093 @default.
• W2070785110 hasConceptScore W2070785110C205260736 @default.
• W2070785110 hasConceptScore W2070785110C25498285 @default.
• W2070785110 hasConceptScore W2070785110C2776914184 @default.
• W2070785110 hasConceptScore W2070785110C2776925932 @default.
• W2070785110 hasConceptScore W2070785110C2779134260 @default.

• next